My lab focuses on the molecular host-pathogen and vector-pathogen interactions. Vector-borne pathogens have evolved in close relationship with their vectors and hosts for thousands of years. Thus, they have acquired mechanisms to manipulate the cellular machinery of both, the vector and the mammalian host. I am interested in how vector-borne pathogens influence host and vector cellular responses, such as immune responses, cellular trafficking, and vesicle secretion.
We are also interested in how tick-borne pathogens sense environmental changes when moving between the vector and the mammalian host. Members of the Anaplasmataceae change their protein profile during their development within the mammalian host when compared to the vector. We want to use these bacteria as a model to understand what clues intracellular bacteria use to detect changes in environment. This knowledge could lead to development of interventions to disrupt the life cycle of tick-borne pathogens, and prevent disease in humans and animals.
- Ph.D. in Entomology, University of Minnesota - (Minneapolis, Minnesota, United States) 2014
- M.Sc. in Entomology, University of Minnesota - (Minneapolis, Minnesota, United States) 2008
- B.Sc. in Agricultural Engineering, Zamorano Pan-American Agricultural School - (Tegucigalpa, Honduras) 2003
- Leal-Galvan, B., Harvey, C., Thomas, D., Saelao, P., & Oliva Chavez, A. S. (2022). Isolation of microRNAs from Tick Ex Vivo Salivary Gland Cultures and Extracellular Vesicles. Journal of Visualized Experiments. (182),
- Skinner, K. M., Underwood, J., Ghosh, A., Oliva Chavez, A. S., & Brelsfoard, C. L (2022). Wolbachia Impacts Anaplasma Infection in Ixodes scapularis Tick Cells. International Journal of Environmental Research and Public Health. 19(3), 1051-1051.
- Park, J. M., Oliva Chvez, A. S., & Shaw, D. K. (2021). Ticks: More Than Just a Pathogen Delivery Service. Frontiers in Cellular and Infection Microbiology. 11, 739419.
- Oliva Chvez, A. S., Wang, X., Marnin, L., Archer, N. K., Hammond, H. L., Carroll, E., ... Pedra, J. (2021). Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection.. Nat Commun. 12(1), 3696.
- Pham, M., Underwood, J., & Oliva Chvez, A. S. (2021). Changing the Recipe: Pathogen Directed Changes in Tick Saliva Components.. Int J Environ Res Public Health. 18(4), 1806-1806.
- Munderloh, U. G., Felsheim, R. F., Burkhardt, N. Y., Herron, M. J., Oliva Chvez, A. S., Nelson, C. M., & Kurtti, T. J. (2012). The Way Forward: Improving Genetic Systems. Intracellular Pathogens II. 416-432. ASM Press.
Repository Documents / Preprints1
- Ante, V. M., Farris, L. C., Saputra, E. P., Hall, A. J., OBier, N. S., Chavez, A., ... Hyde, J. A. (2021). The Borrelia burgdorferi adenylyl cyclase, CyaB, is important for virulence factor production and mammalian infection.