Hook, Magnus individual record
Professor
Positions:
overview

The primary interest of our laboratory is to try to understand the structural function of the extracellular matrix. Of particular interest is the study of the molecular mechanisms of microbial adhesion to host tissue. This process, which is believed to represent a critical initial step in the development of infections, involves specific cell-surface proteins that recognize and bind with a high affinity to components in the host tissue. Our goal is to decipher these events at a molecular level and, based on structural analysis of the interacting components, design new strategies to prevent and treat infections.

education and training
selected publications
Academic Articles290
  • Evans, S. E., Tseng, C., Scott, B. L., Höök, A. M., & Dickey, B. F. (2020). Inducible Epithelial Resistance against Coronavirus Pneumonia in Mice.. Am J Respir Cell Mol Biol. 63(4), 540-541.
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  • Post, A., Isgandarova, S., Martinez-Moczygemba, M., Hahn, M., Russell, B., Hook, M., & Cosgriff-Hernandez, E. (2019). Elucidation of Endothelial Cell Hemostatic Regulation with Integrin-Targeting Hydrogels.. Ann Biomed Eng. 47(3), 866-877.
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  • Diaz Quiroz, J. F., Rodriguez, P. D., Erndt-Marino, J. D., Guiza, V., Balouch, B., Graf, T., ... Hahn, M. S. (2018). Collagen-Mimetic Proteins with Tunable Integrin Binding Sites for Vascular Graft Coatings.. ACS Biomater Sci Eng. 4(8), 2934-2942.
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  • Cereceres, S., Touchet, T., Browning, M. B., Smith, C., Rivera, J., Hk, M., ... Cosgriff-Hernandez, E. (2018). Chronic Wound Dressings Based on Collagen-Mimetic Proteins.. Adv Wound Care (New Rochelle). 4(8), 444-456.
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  • Casillas-Ituarte, N. N., Cruz, C., Lins, R. D., DiBartola, A. C., Howard, J., Liang, X., ... Lower, S. K. (2017). Amino acid polymorphisms in the fibronectin-binding repeats of fibronectin-binding protein A affect bond strength and fibronectin conformation.. J Biol Chem. 292(21), 8797-8810.
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Chapters1
  • Visai, L., Ferrari, D., Barbu, E. M., Liang, X., Ganesh, V. K., Hk, M., & Imbriani, M. (2014). Staphylococcal biofilm formation and development: Related diseases, host immune responses and therapy. Prokaryotes: Physiology, Biochemistry and Cell Behavior. 1-33.
Conference Papers8
  • Hk, M., Smeds, E., Ganesh, V., Francis, P., Ko, Y. P., Ross, C., & Kang, M. (2011). MSCRAMMS in staphylococcal Bone infections. European Cells and Materials. 21(SUPPL.2), 12.
  • Francis, M. P., Vazquez, V., Vannakambadi, G., & Hk, M. (2011). Sequence changes in the isoforms of staphylococcal MSCRAMMs Bbp/SdrE affect ligand specificity. European Cells and Materials. 21(SUPPL.2), 48.
  • Hk, M. (2008). The role of MSCRAMMs in staphylococcal skeletal infections. European Cells and Materials. 16(SUPPL. 4), 11.
  • Peterson, S. B., Ferdous, Z., Hk, M., & Grande-Allen, K. J. (2007). Decorin deficient cells demonstrate increased proliferation and altered phenotypic properties. Proceedings of the ASME Summer Bioengineering Conference 2007, SBC 2007. 985-986.
  • Simpson, K. H., Bowden, G., Hook, M., & Anvari, B. (2003). Optical measurements of dynamic adhesive forces between bacteria and protein-coated surfaces. SPIE Proceedings, Biomedical Optics 2003. 4962, 263-270.
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patents
Patents36
chaired theses and dissertations
Email
mhook@ibt.tamhsc.edu
First Name
Magnus
Last Name
Hook
mailing address
Texas A&M Health Science Center; Ibt-Office Of The Director; 1201 TAMUS
Houston, TX 77030-3303
USA