Hook, Magnus
individual record
Professor
Positions:
- Regents & Distinguished Professor and Director, Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology
overview
The primary interest of our laboratory is to try to understand the structural function of the extracellular matrix. Of particular interest is the study of the molecular mechanisms of microbial adhesion to host tissue. This process, which is believed to represent a critical initial step in the development of infections, involves specific cell-surface proteins that recognize and bind with a high affinity to components in the host tissue. Our goal is to decipher these events at a molecular level and, based on structural analysis of the interacting components, design new strategies to prevent and treat infections.
education and training
- Ph.D. in , Uppsala University - (Uppsala, Sweden) 1974
- B.S. in , Uppsala University - (Uppsala, Sweden) 1971
selected publications
Academic Articles325
- Pagba, C. V., Gupta, A. K., Naji, A. K., van der Hoeven, D., Churion, K., Liang, X., ... Gorfe, A. A. (2022). KRAS Inhibitor that Simultaneously Inhibits Nucleotide Exchange Activity and Effector Engagement.. 2(6), 617-626.
- Negrn, O., Hur, W. S., Prasad, J., Paul, D. S., Rowe, S. E., Degen, J. L., ... Flick, M. J. (2022). Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection.. PLoS Pathogens. 18(1), e1010227-e1010227.
- Picker, J., Lan, Z., Arora, S., Green, M., Hahn, M., Cosgriff-Hernandez, E., & Hook, M. (2022). Prokaryotic Collagen-Like Proteins as Novel Biomaterials.. Frontiers in Bioengineering and Biotechnology. 10, 840939.
- Borza, C. M., Bolas, G., Zhang, X., Browning Monroe, M. B., Zhang, M., Meiler, J., ... Pozzi, A. (2022). The Collagen Receptor Discoidin Domain Receptor 1b Enhances Integrin 1-Mediated Cell Migration by Interacting With Talin and Promoting Rac1 Activation.. Frontiers in Cell and Developmental Biology. 10, 836797.
- Thomas, S., Arora, S., Liu, W., Churion, K., Wu, Y., & Hk, M. (2021). vhp Is a Fibrinogen-Binding Protein Related to vWbp in Staphylococcus aureus.. mBio. 12(4), e0116721-e01121.
Chapters14
- Visai, L., Ferrari, D., Barbu, E. M., Liang, X., Ganesh, V. K., Hk, M., & Imbriani, M. (2014). Staphylococcal biofilm formation and development: Related diseases, host immune responses and therapy. Prokaryotes: Physiology, Biochemistry and Cell Behavior. 1-33.
- Shinomura, T., Ito, K., & Hk, M. (2002). Differential gene trap: A new strategy for identifying genes regulated during cartilage differentiation. The Many Faces of Osteoarthritis. 309-311. Springer Nature.
- Gurusiddappa, S., Xu, Y. i., Rich, R. L., Owens, R. T., Keene, D. R., Mayne, R., Hk, A., & Hk, M. (2001). The Synthesis of Collagen Peptides and Characterization of Their Inhibitory Effects on the Collagen Binding Activities of Integrins 11 and 21. Peptides: The Wave of the Future. 735-736. Springer Nature.
- Foster, T. J., & Hk, M. (2000). Molecular Basis of Adherence of Staphylococcus aureus to Biomaterials. Infections Associated with Indwelling Medical Devices. 27-39. American Society for Microbiology.
- Gurusiddappa, S., & Hk, M. (1994). Synthetic Peptides Mimic the Active Sites of Fibronectin Receptors from Gram-Positive Bacteria. Peptides. 251-257. Springer Nature.
Conference Papers9
- Hk, M., Smeds, E., Ganesh, V., Francis, P., Ko, Y. P., Ross, C., & Kang, M. (2011). MSCRAMMS in staphylococcal Bone infections. European Cells and Materials. 21(SUPPL.2), 12.
- Francis, M. P., Vazquez, V., Vannakambadi, G., & Hk, M. (2011). Sequence changes in the isoforms of staphylococcal MSCRAMMs Bbp/SdrE affect ligand specificity. European Cells and Materials. 21(SUPPL.2), 48.
- Hk, M. (2008). The role of MSCRAMMs in staphylococcal skeletal infections. European Cells and Materials. 16(SUPPL. 4), 11.
- Peterson, S. B., Ferdous, Z., Hk, M., & Grande-Allen, K. J. (2007). Decorin Deficient Cells Demonstrate Increased Proliferation and Altered Phenotypic Properties. ASME 2007 Summer Bioengineering Conference. 985-986.
- Simpson, K. H., Bowden, G., Hook, M., & Anvari, B. (2003). Optical measurements of dynamic adhesive forces between bacteria and protein-coated surfaces. Proceedings of SPIE, Manipulation and Analysis of Biomolecules, Cells, and Tissues. 4962, 263-270.
Repository Documents / Preprints2
- Bertoglio, F., Ko, Y., Thomas, S., Giordano, L., Scommegna, F. R., Meier, D., ... Visai, L. (2022). Antibodies to Coagulase of Staphylococcus aureus crossreact to Efb and reveal different binding of shared Fibrinogen binding repeats.
- DebRoy, S., Tobar, V. A., Galvez, G., Arora, S., Liang, X., Horstmann, N., ... Shelburne, S. A. (2020). Genome-wide analysis of in vivo CcpA binding with and without its key co-factor HPr in the major human pathogen group A Streptococcus.
patents
Patents37
- Hook, M., Ko, Y., Smeds, E., & Ganesh, V. K. (2021). Crystal structure of Staphylococcus aureus clumping factor A in complex with fibrinogen derived peptide and uses thereof.
- Hook, M., Xu, X., & Kim, J. (2019). Specific binding sites in collagen for integrins and use thereof.
- Russell, B., Hook, M., Hahn, M., Cosgriff-hernandez, E., Seo, N., Xu, M., Rivera, J., & Browning, M. (2017). Designer collagens and use thereof.
- Maher, S., Schwartz, J., Hook, A., Russell, B., & Jones, C. (2013). Composition for the attachment of implants to collagen or other components of biological tissue.
- Russell, B., Hook, M., Hahn, M., Cosgriff-hernandez, E., Seo, N., & Xu, M. (2013). Designer collagens and use thereof.
researcher on
Principal Investigator2
- Analysis of Staphylococcus Aureus Host Interactions awarded by National Institute of Infectious Diseases 2012 - 2016
Co-Principal Investigator2
- Multilayer Vascular Grafts Based on Collagen-Mimetic Hydrogels awarded by National Institutes of Health 2012 - 2018
recent teaching activities
- BICH491 Hnr-research Instructor
- BICH491 Research Instructor
- BICH491 Research:in-ab Instructor
- BICH691 Research Instructor
- IBST691 Research Credit: Medical Sci Instructor
chaired theses and dissertations
- Francis, Mathew Prashanth (2015-04). Understanding the Structural Basis for Functional Differences in Staphylococcal MSCRAMMS SDRE1 and BBP/SDRE2 and Their Role in Species Tropism. (Doctoral Dissertation)
Email
First Name
Magnus
Last Name
Hook
mailing address
Texas A&M Health Science Center; Ibt-Office Of The Director; 1201 TAMUS
Houston, TX 77030-3303
USA