overview

McMahan and his research group provide one of the cornerstones for Texas A&M's new Interdisciplinary Life Sciences Building and its related teaching and research efforts. His work focuses on how the nervous system's synapses form in the embryo and function in the adult in various animal species. It relies on high-resolution imaging, chemical characterization and experimental manipulation of specific macromolecules and organelles, which altogether provide insights unobtainable via any other approach. The findings bear directly on the problems of understanding the molecular basis of human brain diseases and restoring brain function after trauma.

selected publications
Academic Articles48
  • Jung, J. H., Szule, J. A., Stouder, K., Marshall, R. M., & McMahan, U. J. (2018). Active Zone Material-Directed Orientation, Docking, and Fusion of Dense Core Vesicles Alongside Synaptic Vesicles at Neuromuscular Junctions.. Front Neuroanat. 12, 72.
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  • Jung, J. H., Szule, J. A., Marshall, R. M., & McMahan, U. J. (2016). Variable priming of a docked synaptic vesicle.. Proc Natl Acad Sci U S A. 113(8), E1098-E1107.
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  • Szule, J. A., Jung, J. H., & McMahan, U. J. (2015). The structure and function of 'active zone material' at synapses.. Philos Trans R Soc Lond B Biol Sci. 370(1672), 20140189-20140189.
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  • Nagwaney, S., Harlow, M. L., Jung, J. H., Szule, J. A., Ress, D., Xu, J., Marshall, R. M., & McMahan, U. J. (2009). Macromolecular connections of active zone material to docked synaptic vesicles and presynaptic membrane at neuromuscular junctions of mouse.. J Comp Neurol. 513(5), 457-468.
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  • Ress, D. B., Harlow, M. L., Marshall, R. M., & McMahan, U. J. (2004). Methods for generating high-resolution structural models from electron microscope tomography data.. Structure. 12(10), 1763-1774.
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Conference Papers7
  • Szule, J., Jung, J. H., Marshall, R. M., & McMahan, U. J. (2010). Connections of Synaptic Vesicles to Active Zone Material Before and after Docking on the Presynaptic. Biophysical Journal. 98(3), 141a-141a.
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  • Jung, J. H., Szule, J. A., Marshall, R. M., & McMahan, U. J. (2010). Physical Changes in Macromolecules of Active Zone Material that Regulate the Docking and Fusion of Synaptic Vesicles on the Presynaptic Membrane. Biophysical Journal. 98(3), 141a-141a.
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  • Ress, D., Harlow, M. L., Marshall, R. M., & McMahan, U. J. (2003). Optimization Method for Isodensity Surface Models Obtained with Electron Microscope Tomography Data. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 1, 774-777.
  • Harlow, M., Ress, D., Koster, A., Marshall, R. M., Schwarz, M., & McMahan, U. J. (1998). Dissection of active zones at the neuromuscular junction by EM tomography.. J Physiol Paris. 92(2), 75-78.
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  • Magill-Solc, C., & McMahan, U. J. (1990). Synthesis and transport of agrin-like molecules in motor neurons.. J Exp Biol. 153(1), 1-10.
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Email
grantser@tamu.edu
First Name
Uel
Last Name
Mcmahan
mailing address
Texas A&M University; Biology; 3258 TAMU
College Station, TX 77843-3258
USA