Heart failure (impaired ventricular pump function) is an eventual outcome for diverse cardiovascular disorders and the leading cause of combined morbidity and mortality in the United States and other developed industrial nations. The focus of my lab is to understand the molecular mechanisms that initiate and mediate the pathogenesis of maladaptive cardiac remodeling, such as cardiac hypertrophy and fibrosis, as a result of various stresses such as ischemic, hemodynamic or metabolic challenges. The overall approach consists of using molecular and genetic engineering, clinically-relevant mouse models by generating constitutive and inducible transgenic mice as well as straight and conditional knockout mice with different cardiomyopathy.

selected publications
Academic Articles36
  • Dai, Y., Luo, W., & Chang, J. (2018). Rho kinase signaling and cardiac physiology. Current Opinion in Physiology. 1, 14-20.
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  • Dai, Y., Song, J., Li, W., Yang, T., Yue, X., Lin, X. i., ... Chang, J. (2018). RhoE Fine-Tunes Inflammatory Response in Myocardial Infarction.. CIRCULATION.
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  • Cao, J., Yu, Y., Zhang, Z., Chen, X., Hu, Z., Tong, Q., ... Lin, X. (2018). SCP4 promotes gluconeogenesis through FoxO1/3a dephosphorylation. DIABETES. 67(1), 46-57.
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  • Yi, X., Tao, Y., Lin, X., Dai, Y., Yang, T., Yue, X., ... Chang, J. (2017). Histone methyltransferase Setd2 is critical for the proliferation and differentiation of myoblasts. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1864(4), 697-707.
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  • Jie, W., Andrade, K. C., Lin, X., Yang, X., Yue, X., & Chang, J. (2016). Pathophysiological functions of Rnd3/RhoE. COMPREHENSIVE PHYSIOLOGY. 6(1), 169-186.
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Conference Papers7
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Ibt Center For Translational Cancer Research; Texas A&M College of Medicine; 1201 TAMUS
Houston, TX 77030-3303