Brunauer, Regina individual record
Research Assistant Professor
overview

My research revolves around understanding how aging affects regeneration. I have addressed this question by investigating mesenchymal stem cell aging in humans and progeroid mice. In my current position as Research Assistant Professor, I am exploring the effects of aging and progeria on a new in vivo model for regeneration, the mouse digit tip, which involves regeneration of bone, nail, skin and vasculature, and requires not only stem cells, but also various other cell types to interact in a well-balanced and timely manner. I have recently established that aging delays bone regeneration in this model by attenuating both osteoclast and osteoprogenitor activity, and will now examine which specific aging processes impair osteoclast and osteoprogenitor recruitment, proliferation and differentiation, with the long term goal to improve fracture healing in the elderly.

education and training
selected publications
Academic Articles17
  • Dolan, C. P., Imholt, F., Yang, T., Bokhari, R., Gregory, J., Yan, M., ... Muneoka, K. (2022). Mouse Digit Tip Regeneration Is Mechanical Load Dependent. Journal of Bone and Mineral Research. 37(2), 312-322.
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  • Dolan, C. P., Yang, T., Zimmel, K., Imholt, F., Qureshi, O., Falck, A., ... Brunauer, R (2022). Epimorphic regeneration of the mouse digit tip is finite. Stem Cell Research & Therapy. 13(1), 62.
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  • Dawson, L. A., Schanes, P. P., Marrero, L., Jordan, K., Brunauer, R., Zimmel, K. N., ... Muneoka, K (2021). Proximal digit tip amputation initiates simultaneous blastema and transient fibrosis formation and results in partial regeneration.. Wound Repair Regen. 29(1), 196-205.
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  • Osorio-Paz, I., Brunauer, R., & Alavez, S. (2020). Beer and its non-alcoholic compounds in health and disease.. Crit Rev Food Sci Nutr. 60(20), 3492-3505.
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  • Schreiber, K. H., Arriola Apelo, S. I., Yu, D., Brinkman, J. A., Velarde, M. C., Syed, F. A., ... Lamming, D. W. (2019). A novel rapamycin analog is highly selective for mTORC1 in vivo.. Nat Commun. 10(1), 3194.
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Chapters1
  • Brunauer, R., Reitinger, S., & Lepperdinger, G. (2012). Agelessness of mesenchymal stem cells. Perloft, J. W., & Wong, A. H. (Eds.), Cell Aging. 215-239. Nova Publishers.
Conference Papers7
  • Brunauer, R., Xia, I., Asrar, S., Dawson, L., Dolan, C., & Muneoka, K. (2020). Aging delays epimorphic regeneration in mice. JOURNAL OF BONE AND MINERAL RESEARCH. 35, 163-163.
  • Brunauer, R., & Muneoka, K. (2017). Mouse digit regeneration: a new model to study age-related regenerative decline.. JOURNAL OF BONE AND MINERAL RESEARCH. 32, S217-S217.
  • Brunauer, R., Laschober, G., Fehrer, C., & Lepperdinger, G (2011). Age-associated functional changes of human mesenchymal stem cells. Experimental Gerontology. 46(2-3), 211-211.
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  • Trimmel, D., Brunauer, R., Laschober, G. T., Kloss, F., Gassner, R., & Lepperdinger, G (2011). Proliferation and differentiation of human bone-derived mesenchymal stem cells are affected by NADPH oxidase 4-produced ROS. Experimental Gerontology. 46(2-3), 208-208.
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  • Herndler-Brandstetter, D., Landgraf, K., Jenewein, B., Tzankov, A., Brunauer, R., Parson, W., ... Grubeck-Loebenstein, B (2010). Human bone marrow hosts polyfunctional memory CD4 and CD8 T cells with close contact to IL-15-producing stromal cells. IMMUNOLOGY. 131, 136-136.
recent teaching activities
Email
rbrunauer@tamu.edu
First Name
Regina
Last Name
Brunauer
mailing address
Texas A&M University; Vet Med - Physiology & Pharmacology; 4466 TAMU
College Station, TX 77843-4466
USA