Maxwell, Steven individual record
Associate Professor
overview

My primary interests include Cancer; Oncogenes; Tumor Suppressor; Genes Programmed Cell Death (apoptosis); Chemoresistance, and Angiogenesis. My laboratory studies mechanisms of evolution of chemoresistance in diffuse large B-cell lymphoma (DLBCL). One current primary objective is to conduct a Phase I study that (1) confirms RTI-79 safety in platinum-resistant/refractory ovarian cancer patients, and (2) demonstrates signals of efficacy in humans (ex: time-to-disease progression and changes in CA125 biomarker). A second objective is to better define the RTI-79 mechanism of action (MOA) by (1) determining how RTI-79 causes a rapid burst in superoxides, and (2) elucidating the basis of Nrf-2 pathway downregulation.

selected publications
Academic Articles67
  • Dave, J. M., Kang, H., Abbey, C. A., Maxwell, S. A., & Bayless, K. J. (2013). Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK).. J Biol Chem. 288(42), 30720-30733.
    doi badge pubmed badge
  • Maxwell, S. A., & Mousavi-Fard, S. (2013). Non-Hodgkin's B-cell lymphoma: advances in molecular strategies targeting drug resistance.. Exp Biol Med (Maywood). 238(9), 971-990.
    doi badge pubmed badge
  • Kwak, H., Kang, H., Dave, J. M., Mendoza, E. A., Su, S., Maxwell, S. A., & Bayless, K. J. (2012). Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation.. Angiogenesis. 15(2), 287-303.
    doi badge pubmed badge
  • Maxwell, S. A., Cherry, E. M., & Bayless, K. J. (2011). Akt, 14-3-3, and vimentin mediate a drug-resistant invasive phenotype in diffuse large B-cell lymphoma.. Leuk Lymphoma. 52(5), 849-864.
    doi badge pubmed badge
  • Maxwell, S. A., Li, Z., Jaye, D., Ballard, S., Ferrell, J., & Fu, H. (2010). 14-3-3 mediates resistance of diffuse large B cell lymphoma to an anthracycline-based chemotherapeutic regimen.. Journal of Biological Chemistry. 285(49), 38740-38740.
    doi badge
Books1
  • Mukhopadhyay, T., Maxwell, S. A., & Roth, J. A. (1995). p53 Suppressor Gene. Springer Berlin Heidelberg.
    doi badge
Chapters1
  • Maxwell, S. A. (2013). Tumor suppressor activities of proline oxidase. Proline: Biosynthesis, Regulation and Health Benefits. 135-159.
Conference Papers9
  • Dave, J. M., Maxwell, S. A., & Bayless, K. J. (2012). RACK1 and vimentin complex to regulate FAK during endothelial invasion.. MOLECULAR BIOLOGY OF THE CELL. 23,
  • Cherry, E. M., Bayless, K. J., & Maxwell, S. A. (2011). Abstract 702: Drug resistance and invasion in diffuse large B-cell lymphoma are mediated by Akt, 14-3-3, and Vimentin. Cancer Research. 71(8_Supplement), 702-702.
    doi badge
  • Bayless, K. J., Kwak, H., Mendoza, E. A., & Maxwell, S. A. (2007). ADAM17 mediates endothelial invasion in three-dimensional collagen matrices. FASEB JOURNAL. 21(5), A194-A194.
  • Davis, G. E., Bell, S. E., Bayless, K. J., Salazar, R., Pintar, K. A., Suhasini, K., & Maxwell, S. A. (2000). Molecular regulation of capillary morphogenesis and regression in three-dimensional extracellular matrix environments.. FASEB JOURNAL. 14(4), A787-A787.
patents
Patents3
recent teaching activities
Email
s-maxwell@tamu.edu
First Name
Steven
Last Name
Maxwell
mailing address
Texas A&M Health Science Center; Molecular And Cellular Medicine; 1114 TAMUS
College Station, TX 77843-1114
USA