Maxwell, Steven individual record
Associate Professor
overview

My primary interests include Cancer; Oncogenes; Tumor Suppressor; Genes Programmed Cell Death (apoptosis); Chemoresistance, and Angiogenesis. My laboratory studies mechanisms of evolution of chemoresistance in diffuse large B-cell lymphoma (DLBCL). One current primary objective is to conduct a Phase I study that (1) confirms RTI-79 safety in platinum-resistant/refractory ovarian cancer patients, and (2) demonstrates signals of efficacy in humans (ex: time-to-disease progression and changes in CA125 biomarker). A second objective is to better define the RTI-79 mechanism of action (MOA) by (1) determining how RTI-79 causes a rapid burst in superoxides, and (2) elucidating the basis of Nrf-2 pathway downregulation.

selected publications
Academic Articles67
Chapters1
  • Maxwell, S. A. (2013). Tumor suppressor activities of proline oxidase. Proline: Biosynthesis, Regulation and Health Benefits. (pp. 135-159).
Conference Papers9
Email
s-maxwell@tamu.edu
First Name
Steven
Last Name
Maxwell
mailing address
Texas A&M Health Science Center; Molecular And Cellular Medicine; 1114 TAMUS
College Station, TX 77843-1114
USA