Maxwell, Steven
individual record
Associate Professor
Positions:
- Associate Professor, Cell Biology and Genetics, College of Medicine
overview
My primary interests include Cancer; Oncogenes; Tumor Suppressor; Genes Programmed Cell Death (apoptosis); Chemoresistance, and Angiogenesis. My laboratory studies mechanisms of evolution of chemoresistance in diffuse large B-cell lymphoma (DLBCL). One current primary objective is to conduct a Phase I study that (1) confirms RTI-79 safety in platinum-resistant/refractory ovarian cancer patients, and (2) demonstrates signals of efficacy in humans (ex: time-to-disease progression and changes in CA125 biomarker). A second objective is to better define the RTI-79 mechanism of action (MOA) by (1) determining how RTI-79 causes a rapid burst in superoxides, and (2) elucidating the basis of Nrf-2 pathway downregulation.
education and training
- Baylor College of Medicine - (Houston, Texas, United States), Postdoctoral Training 1990
- The University of Texas MD Anderson Cancer Center - (Houston, Texas, United States), Postdoctoral Training 1987
- Ph.D. in Molecular Virology, The University of Texas Health Science Center at Houston - (Houston, Texas, United States) 1985
- M.S. in Molecular Virology, The University of Texas Health Science Center at Houston - (Houston, Texas, United States) 1982
- B.A. in Chemistry, Abilene Christian University - (Abilene, Texas, United States) 1980
- B.S. in Biology and Chemistry, Abilene Christian University - (Abilene, Texas, United States) 1980
selected publications
Academic Articles67
- Maxwell, S. A., Fuchs-Young, R., Wells, G. B., Kapler, G. M., Conover, G. M., Green, S., ... Huston, D. P. (2022). Guiding Preclinical Medical Students in Finding, Synthesizing, and Communicating Translational Basic Research Literature: Roles for Basic Science Research Mentors.. Academic Medicine. 97(5), 684-688.
- Dave, J. M., Kang, H., Abbey, C. A., Maxwell, S. A., & Bayless, K. J. (2013). Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK).. Journal of Biological Chemistry. 288(42), 30720-30733.
- Maxwell, S. A., & Mousavi-Fard, S. (2013). Non-Hodgkin's B-cell lymphoma: advances in molecular strategies targeting drug resistance.. Experimental Biology and Medicine. 238(9), 971-990.
- Kwak, H., Kang, H., Dave, J. M., Mendoza, E. A., Su, S., Maxwell, S. A., & Bayless, K. J. (2012). Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation.. ANGIOGENESIS. 15(2), 287-303.
- Maxwell, S. A., Cherry, E. M., & Bayless, K. J. (2011). Akt, 14-3-3, and vimentin mediate a drug-resistant invasive phenotype in diffuse large B-cell lymphoma.. 52(5), 849-864.
Books1
Chapters1
- Maxwell, S. A. (2013). Tumor suppressor activities of proline oxidase. Proline: Biosynthesis, Regulation and Health Benefits. 135-159.
Conference Papers10
- Maxwell, S. A., Wallis, D., Zhou, N., Baker, D., Mousavi-Fard, S. H., Loesch, K., ... Sacchettini, J. C. (2022). Development of novel, non-toxic rifamycins that reverse drug resistance. Cancer Research. 82(12),
- Dave, J. M., Maxwell, S. A., & Bayless, K. J. (2012). RACK1 and vimentin complex to regulate FAK during endothelial invasion.. Molecular Biology of the Cell. 23,
- Cherry, E. M., Bayless, K. J., & Maxwell, S. A. (2011). Drug resistance and invasion in diffuse large B-cell lymphoma are mediated by Akt, 14-3-3 zeta, and Vimentin. Cancer Research. 71(8_Supplement), 702-702.
- Bayless, K. J., Kwak, H., Mendoza, E. A., & Maxwell, S. A. (2007). ADAM17 mediates endothelial invasion in three-dimensional collagen matrices. The FASEB Journal. 21(5), A194-A194.
- Maxwell, S. A., & Davis, G. E. (2000). Comparative gene expression profiling in p53-mediated apoptosis-resistant and sensitive endothelial cell lines.. The FASEB Journal. 14(4), A555-A555.
patents
Patents3
- Sacchettini, J., Zhou, N., Baker, D., Maxwell, S., & Wallis, D. (2018). Compositions and methods for drug-sensitization or inhibition of a cancer cell.
- Sacchettini, J., Zhou, N., Baker, D., Maxwell, S., & Wallis, D. (2017). Compositions and methods for drug-sensitization or inhibition of a cancer cell.
- Sacchettini, J., Zhou, N., Baker, D., Maxwell, S., & Wallis, D. (2015). Compositions and methods for drug-sensitization or inhibition of a cancer cell.
recent teaching activities
- MEID618 Medical Student Grand Rounds Block Co-Leader
- MEID705 Seminar Day Instructor
- MSCI691 Research Credit: Medical Sci Instructor
Email
s-maxwell@tamu.edu
First Name
Steven
Last Name
Maxwell
mailing address
Texas A&M Health Science Center; Molecular And Cellular Medicine; 1114 TAMUS
College Station, TX 77843-1114
USA