Scholars

Gregory, Carl

Associate Professor

Positions:

Associate Professor, Molecular and Cellular Medicine, College of Medicine

Research Areas:

Bones--Diseases, Fractures, Bone, Stem cells--Research

Single Page Bio

cgregory@tamu.edu

1 979 436 9643

Co-author Network

Map of Science

ORCID

0000-0001-6444-5541

Research Areas:

Bones--Diseases, Fractures, Bone, Stem cells--Research

overview

Our lab has been examining the biology of MSCs with a view to developing rapid molecular markers and tests for evaluating/purifying maximally efficacious cultures of MSCs. The group also specializes in bone repair by MSCs. Based on detailed characterization of the molecular mechanism of osteoblast differentiation by MSCs, a novel and effective bone regeneration strategy has been developed. Additionally, we are currently examining the effects of various small molecules and immunological strategies for the safe and effective inhibition of Dkk-1 activity in bone tumors.We have recently established methods to model bone-tumor interactions using bioreactors that simulate microgravity.

education and training

Tulane University - (New Orleans, Louisiana, United States), Postdoctoral Training 2004
Wellcome Centre for Cell-Matrix Research - (Manchester, United Kingdom), Postdoctoral Training 1999
Ph.D. in Biochemistry and Molecular Biology, University of Manchester - (Manchester, Manchester, United Kingdom) 1998
B.Sc. in Biochemistry, University of York - (York, York, United Kingdom) 1995

selected publications

Academic Articles53

Xin, S., Dai, J., Gregory, C. A., Han, A., & Alge, D. L. (2020). Creating Physicochemical Gradients in Modular Microporous Annealed Particle Hydrogels via a Microfluidic Method. Advanced Functional Materials. 30(6), 1907102-1907102.
Xin, S., Gregory, C., & Alge, D. L. (2020). Interplay Between Degradability and Integrin Signaling on Mesenchymal Stem Cell Function within Poly(ethylene glycol) Based Microporous Annealed Particle Hydrogels. Acta Biomaterialia. 101, 227-236.
McNeill, E. P., Reese, R. W., Tondon, A., Clough, B. H., Pan, S., Froese, J., ... Gregory, C. A. (2018). Three-dimensional in vitro modeling of malignant bone disease recapitulates experimentally accessible mechanisms of osteoinhibition. CELL DEATH & DISEASE. 9(12), 1161.
Chaput, C. D., Shar, A., Jupiter, D., Hubert, Z., Clough, B., Krause, U., & Gregory, C. A. (2018). How stem cell composition in bone marrow aspirate relates to clinical outcomes when used for cervical spine fusion. PLoS ONE. 13(9), e0203714-e0203714.
Carrow, J. K., Cross, L. M., Reese, R. W., Jaiswal, M. K., Gregory, C. A., Kaunas, R., Singh, I., & Gaharwar, A. K. (2018). Widespread changes in transcriptome profile of human mesenchymal stem cells induced by two-dimensional nanosilicates. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES. 115(17), 201716164-E3913.

Chapters3

Zeitouni, S., Ford, B. S., Harris, S. M., Whitney, M. J., Gregory, C. A., & Prockop, D. J. (2011). Pharmaceutical induction of ApoE secretion. Current Research in Pharmaceutical Technology. (pp. 192-210).
Gregory, C. A. (2008). Mesenchymal stem cells: From culture to clinic. Levičar, N., Habib, N. A., Gordon, M. Y., & Dimarakis, I. (Eds.), Stem Cell Repair and Regeneration: Volume 3. (pp. 21-43). PUBLISHED BY IMPERIAL COLLEGE PRESS AND DISTRIBUTED BY WORLD SCIENTIFIC PUBLISHING CO..
Gregory, C. A., & Prockop, D. J. (2007). Fundamentals of Culture and Characterization of Mesenchymal Stem/Progenitor Cells (MSCs) from Bone Marrow Stroma. Culture of Human Stem Cells. (pp. 207-232). John Wiley %26 Sons, Inc..

Conference Papers6

Mota, S. M., Rogers, R. E., Haskell, A. W., McNeill, E. P., Giger, M. L., Kaunas, R. R., Gregory, C. A., & Maitland, K. C. (2019). Morphological cell image analysis for real-time monitoring of stem cell culture. MATHEMATICAL MODELING AND ESTIMATION TECHNIQUES IN COMPUTER VISION. 10883, 108831i-108831i-7.
Carrow, J. K., Cross, L. M., Reese, R. W., Jaiswal, M. K., Gregory, C. A., Kaunas, R., Singh, I., & Gaharwar, A. K. (2019). Widespread changes in transcriptome profile of human mesenchymal stem cells induced by 2D nanosilicates. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium. 40, 967.
Sears, C., McNeill, E., Clough, B., Jaligama, S., Kameoka, J., Gregory, C. A., & Kaunas, R. (2017). Use of Osteogenically Enhanced Mesenchymal Stem Cells and Their Cell-Derived Matrices for Bone Tissue Engineering. TISSUE ENGINEERING PART A. 23, S29-S29.
Witek, M. A., Chen, G., Shadpour, H., Khaterpal, I., Prockop, D., Gregory, C. A., McCarley, R. L., & Soper, S. A. (2006). Integrated microfluidic system for the processing of membrane proteins isolated from stem cells. 1456-1458.
Gregory, C. A., Gunn, W. G., Reyes, E., Smolarz, A. J., Munoz, J., Spees, J. L., & Prockop, D. J. (2005). How Wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow. TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY. 1049(1), 97-106.