overview

Our laboratory is interested in the pathogenesis of bacterial lung infections particularly tuberculosis and Legionnaires' disease. We are examining the virulence mechanisms of bacteria using cellular, molecular and genetic techniques. Our primary research goal is to obtain a better understanding of the roles of the pathogen and host in disease. These studies should contribute to our understanding of host-pathogen interactions at the molecular and cellular level that can be used for prevention, treatment and diagnosis. We hope that through a better understanding of the mechanisms by which these organisms cause disease we can prevent some, if not all, of these infections in the future.

education and training
selected publications
Academic Articles107
  • Moule, M. G., & Cirillo, J. D. (2020). Mycobacterium tuberculosis Dissemination Plays a Critical Role in Pathogenesis. Frontiers in Cellular and Infection Microbiology. 10,
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  • Galbadage, T., Liu, D., Alemany, L. B., Pal, R., Tour, J. M., Gunasekera, R. S., & Cirillo, J. D. (2019). Molecular Nanomachines Disrupt Bacterial Cell Wall, Increasing Sensitivity of Extensively Drug-Resistant Klebsiella pneumoniae to Meropenem.. ACS Nano. 13(12), 14377-14387.
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  • Durkee, M. S., Cirillo, J. D., & Maitland, K. C. (2019). Fluorescence modeling of in vivo optical detection of Mycobacterium tuberculosis.. Biomed Opt Express. 10(10), 5445-5460.
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  • Fan, X., Xu, J., Files, M., Cirillo, J. D., Endsley, J. J., Zhou, J., & Endsley, M. A. (2019). Dual activity of niclosamide to suppress replication of integrated HIV-1 and Mycobacterium tuberculosis (Beijing).. Tuberculosis (Edinb). 116S, S28-S33.
  • Christensen, L. M., Sule, P., Cirillo, S., Strain, M., Plumlee, Q., Adams, L. G., & Cirillo, J. D. (2019). Legionnaires' Disease Mortality in Guinea Pigs Involves the p45 Mobile Genomic Element.. J Infect Dis. 220(10), 1700-1710.
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Chapters2
  • Kong, Y., & Cirillo, J. D. (2018). Fluorescence Imaging of Mycobacterial Infection in Live Mice Using Fluorescent Protein-Expressing Strains.. Methods Mol Biol. Methods in Molecular Biology. 75-85. Springer New York.
  • Khan, A., Singh, C. R., Soudani, E., Bakhru, P., Saikolappan, S., Cirillo, J. D., ... Jagannath, C. (2014). Autophagy enhances the Efficacy of BCG Vaccine. Autophagy, Infection, and the Immune Response. 245-265. Wiley.
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Conference Papers5
  • Greenberg, M., Maitland, K. C., Smith, R., Glowczwski, A., Lovelady, A., Galbadage, T., ... Cirillo, J. D. (2018). In vitro results of flexible light-emitting antimicrobial bandage designed for prevention of surgical site infections. Light-Based Diagnosis and Treatment of Infectious Diseases, Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases. 10479, 104790m.
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  • Bordin, A. I., Gressler, L. T., Alexander, E., Sule, P., Cirillo, J. D., Edwards, J. F., & Cohen, N. D. (2018). Guinea pig infection with the intracellular pathogen Rhodococcus equi.. Vet Microbiol. 215, 18-22.
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  • Durkee, M. S., Maitland, K. C., & Cirillo, J. D. (2017). A fluorescence model of the murine lung for optical detection of pathogenic bacteria. Clinical and Preclinical Optical Diagnostics, Clinical and Preclinical Optical Diagnostics. 10411, 104110h-104110h-5.
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  • Sule, P., Tilvawala, R., Behinaein, P., Walkup, G. K., & Cirillo, J. D. (2016). New directions using reporter enzyme fluorescence (REF) as a tuberculosis diagnostic platform.. Tuberculosis (Edinb). 101S, S78-S82.
  • Nooshabadi, F., Yang, H., Cheng, Y., Xie, H., Rao, J., Cirillo, J. D., & Maitland, K. C. (2016). Whole-animal imaging of bacterial infection using endoscopic excitation of -lactamase (BlaC)-specific fluorogenic probe. SPIE Proceedings, SPIE BiOS. 9715, 97150h-97150h-5.
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patents
Patents4
chaired theses and dissertations
Email
jdcirillo@tamu.edu
First Name
Jeffrey
Last Name
Cirillo
mailing address
Texas A&M Health Science Center; Microbial Pathogenesis And Immunology; 1359 TAMUS
Bryan, TX 77807
USA