- Assistant Professor, Medical Physiology
Tumor cell metastasis to the regional or draining lymph nodes (LN) is the primary indicator of tumor aggressiveness. Tumor cells lodged in nodes acquire significant vulnerabilities that enable them to evade therapy. In addition, expansion of the vasculature near the primary tumor bed activates multiple pathways that induce lymphangiogenesis and angiogenesis. The primary research focus of my laboratory is to determine how an inflammatory tumor-lymphatic microenvironment contributes to cancer metastasis and progression by reprograming molecular pathways in a) primary tumor niche and b) metastatic tumor draining LNs. We use tumor-LEC 3D spheroids, orthotopic tumor models and clinical samples to evaluate the tumor-lymphatic crosstalk in different solid tumors. In addition, we are also interested in delineating the role of the microbiota and specific tryptophan metabolites in cancer progression, tumor associated lymphangiogenesis and alterations to the metastatic node.
- Ph.D. in Cancer genetics, Indian Institute of Science Bangalore - (Bengaluru, India)
- Texas A&M Health Science Center - (College Station, Texas, United States), Postdoctoral Training
Academic Articles65
- Abbey, C. A., Duran, C. L., Chen, Z., Chen, Y., Roy, S., Coffell, A., ... Bayless, K. J. (2024). Identification of New Markers of Angiogenic Sprouting Using Transcriptomics: New Role for RND3.. Arteriosclerosis, Thrombosis and Vascular Biology.
- Creed, H. A., Kannan, S., Tate, B. L., Godefroy, D., Banerjee, P., Mitchell, B. M., ... Rutkowski, J. M. (2024). Single-Cell RNA Sequencing Identifies Response of Renal Lymphatic Endothelial Cells to Acute Kidney Injury.. Journal of the American Society of Nephrology.
- Maiers, J. L., & Chakraborty, S. (2023). The Cellular, Molecular, and Pathologic Consequences of Stress on the Liver.. American Journal of Pathology. S0002-9440(23)00274-2.
- Banerjee, P., Gaddam, N., Chandler, V., & Chakraborty, S. (2023). Oxidative Stress-Induced Liver Damage and Remodeling of the Liver Vasculature.. American Journal of Pathology. S0002-9440(23)00212-2.
- Chakraborty, S., Dixon, B. J., Rutkowski, J. M., Castorena-Gonzalez, J. A., & Breslin, J. W. (2023). Lymphatic Pathophysiology.. Microcirculation. 30(2-3), e12806.
Chapters2
- Zhang, X., Chakraborty, S., Muthuchamy, M., & Zawieja, D. C. (2021). Isolation of Lymphatic Muscle Cells (LMCs ) from Rat Mesentery.. Methods in molecular biology (Clifton, N.J.). Cardiovascular Development. 137-141. Springer Nature.
- Foskett, A. M., Chakraborty, S., & Muthuchamy, M. (2013). Lymphangiogenesis. Immunology of the Lymphatic System. 3-33. Springer Nature.
Conference Papers21
- Chen, L., Ceci, L., Kennedy, L., Wu, N., Zhou, T., Kyritsi, K., ... Alpini, G. (2022). INHIBITION OF ALPHA-CALCITONIN GENE-RELATED PEPTIDE (.LPHA-CGRP) SIGNALING ATTENUATES METHIONINE-AND CHOLINE-DEFICIENT DIET (MCD)-INDUCED NONALCOHOLIC STEATOHEPATITIS (NASH) PHENOTYPES. Hepatology. 76, S602-S603.
- Wilcox, B. K., Navaneethabalakrishnan, S., Martinez, K. A., Pournouri, A., Henley, M. R., Goodlett, B. L., ... Mitchell, B. M. (2021). Hypertensive Stimuli Indirectly Stimulate Mouse Mesometrial Lymphangiogenesis Through Immune Cells. HYPERTENSION. 78(Suppl_1),
- Seelig, C., Kumaravel, S., Roy, S., Singh, S., Glaser, S., & Chakraborty, S. (2021). Serotonin Induces Inflammatory Cytokine Production and Regulates Lymphatic Endothelial Cell Function. The FASEB Journal. 35(S1),
- Chen, L., Kennedy, L., Kyritsi, K., Wu, C., Ceci, L., Ekser, B., ... Glaser, S. S. (2021). FREE FATTY ACIDS-INDUCED ACTIVATION OF THE ALPHA-CALCITONIN GENE-RELATED PEPTIDE (ACGRP)/CALCITONIN RECEPTOR-LIKE RECEPTOR (CRLR)/RECEPTOR ACTIVITY-MODIFYING PROTEIN 1 (RAMP1) AXIS REGULATES MIR-125B EXPRESSION VIA TLR4 IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD). Hepatology. 74, 1063A-1064A.
- Kyritsi, K., Kennedy, L., Carpino, G., Wu, N., Chen, L., Meyer, A. A., ... Glaser, S. S. (2021). INHIBITION OF THE SUBSTANCE P/NEUROKININ RECEPTOR (SP/NK1R) AXIS AMELIORATES LIVER PHENOTYPES IN A MODEL OF NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD). Hepatology. 74, 1073A-1073A.
Repository Documents / Preprints3
- Penarete-Acosta, D., Stading, R., Emerson, L., Horn, M., Chakraborty, S., Han, A., & Jayaraman, A. (2023). A microfluidic model of colonocyte-microbiota interaction mimicking the colorectal cancer microenvironment.
- Johnson, S. C., Chakraborty, S., Drosou, A., Cunnea, P., Tzovaras, D., Nixon, K., ... Moore, J. E. (2020). Inflammatory state of lymphatic vessels and miRNA profiles associated with relapse in ovarian cancer patients.
- Lee, Y., Chakraborty, S., & Muthuchamy, M. (2020). Roles of sarcoplasmic reticulum Ca2+ ATPase pump in the impairments of lymphatic contractile activity in a metabolic syndrome rat model.
Principal Investigator2
Co-Principal Investigator1
- BICH691 Research Instructor
- BIOT684 Directed Pro Internship: In-ab Instructor
- BIOT684 Directed Prof Intern: In-ab Instructor
- BIOT684 Directed Prof Internship Instructor
- BIOT684 Directed Prof Internship Instructor