overview

Bacteria have a limited behavioral repertoire. Their most conspicuous behavior is chemotaxis - the pursuit of molecules that are favorable to acquire and the avoidance of chemicals that are best to avoid. The simplicity of bacterial motility and chemotaxis and the amenability of the model species Escherichia coli to genetic, biochemical and physiological manipulation have facilitated rapid advances in understanding the molecular mechanisms of biological energy conversion and signal transduction.



Our laboratory studies the inputs and outputs of chemotaxis. Ligands interact with the periplasmic receptor domain of a chemotactic signal transducer that spans the cell membrane. This interaction is converted into an intracellular signal that is communicated to the flagella. Molecules can be sensed either by binding directly to a receptor or by first interacting with a periplasmic binding protein, which then interacts with a receptor.

selected publications
Academic Articles73
  • Manson, M. D. (2020). Howard Berg's Random Walk through Biology.. J Bacteriol. 202(23),
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  • Yang, J., Chawla, R., Rhee, K. Y., Gupta, R., Manson, M. D., Jayaraman, A., & Lele, P. P. (2020). Biphasic chemotaxis of Escherichia coli to the microbiota metabolite indole.. Proc Natl Acad Sci U S A. 117(11), 6114-6120.
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  • Pasupuleti, S., Sule, N., Manson, M. D., & Jayaraman, A. (2018). Conversion of Norepinephrine to 3,4-Dihdroxymandelic Acid in Escherichia coli Requires the QseBC Quorum-Sensing System and the FeaR Transcription Factor.. J Bacteriol. 200(1), e00564-e00517.
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  • Jani, S., Seely, A. L., Peabody V, G. L., Jayaraman, A., & Manson, M. D. (2017). Chemotaxis to self-generated AI-2 promotes biofilm formation in Escherichia coli.. Microbiology (Reading). 163(12), 1778-1790.
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  • Sule, N., Pasupuleti, S., Kohli, N., Menon, R., Dangott, L. J., Manson, M. D., & Jayaraman, A. (2017). The Norepinephrine Metabolite 3,4-Dihydroxymandelic Acid Is Produced by the Commensal Microbiota and Promotes Chemotaxis and Virulence Gene Expression in Enterohemorrhagic Escherichia coli.. Infect Immun. 85(10), e00431-e00417.
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Chapters2
  • Manson, M. D. (2018). The Diversity of Bacterial Chemosensing.. Methods Mol Biol. Methods in Molecular Biology. 3-6. Springer New York.
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  • Manson, M. D. (2018). Transmembrane Signal Transduction in Bacterial Chemosensing.. Methods Mol Biol. Methods in Molecular Biology. 7-19. Springer New York.
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Conference Papers5
  • Hegde, M., Englert, D. L., Wood, T., Manson, M., & Jayaraman, A. (2010). Listening to new signals with old ears: Sensing and recognition of the quorum sensing signal AI-2 by the TSR chemoreceptor. AIChE Annual Meeting, Conference Proceedings.
  • McAndrew, R. S., Ellis, E. A., Lai, R., Manson, M., & Holzenburg, A. (2006). Effects of Chemoreceptor Modification on the Structure of Tsr Arrays. Microscopy and Microanalysis. 12(S02), 378-379.
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  • McAndrew, R. S., Ellis, E. A., Manson, M., & Holzenburg, A. (2004). TEM Anaysis of Chemoreceptor Arrays in Native Membranes of E. coli. Microscopy and Microanalysis. 10(S02), 416-417.
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  • Young, J. J., Lee, C. C., Malshe, A. P., Tung, S., & Manson, M. D. (2001). Design and fabrication of a cellular motor driven micro fluidic system. ASME International Mechanical Engineering Congress and Exposition, Proceedings. 2, 3045-3051.
  • Young, J. J., Malshe, A. P., Lee, C. C., Tung, S., & Manson, M. D. (2001). Design and fabrication of a cellular motor driven micro fluidic system. American Society of Mechanical Engineers, Micro-Electromechanical Systems Division Publication (MEMS). 3, 471-477.
in the news
researcher on
Principal Investigator1
chaired theses and dissertations
Email
m-manson9@tamu.edu
First Name
Michael
Last Name
Manson
mailing address
Texas A&M University; Biology; 3258 TAMU
College Station, TX 77843-3258
USA