Zhang, Dekai
individual record
Associate Professor
Positions:
- Associate Professor, Institute of Biosciences and Technology, College of Medicine
- Associate Professor, Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology
overview
Our laboratory is studying the molecular mechanisms of innate immune recognition by identification and analysis of receptors involved in innate immune recognition and activated signaling pathways. We are particularly interested in the recently identified family of Toll-like receptors, which play a critical role in the mounting of innate immune responses. We wish to understand the mechanisms by which TLRs recognize different pathogen associate molecular patterns (PAMPs), as well as the regulatory mechanisms of TLR signal pathways that lead to NF- k B activation. We are also interested in studying the important links between chronic infection, inflammation and cancer by utilizing biochemical as well as whole animal approaches.
education and training
- Howard Hughes Medical Institute - (Chevy Chase, Maryland, United States), Postdoctoral Training 2005
- Yale University - (New Haven, Connecticut, United States), Postdoctoral Training 2001
- Ph.D. in Oncology/Cell Biology, University of Hong Kong - (Hong Kong, Hong Kong, China) 1998
- M.D. in Internal Medicine, Harbin University - (Harbin, China) 1993
- B.S. in Medical Science, Harbin University - (Harbin, China) 1988
selected publications
Academic Articles43
- Du, B., Fan, Y. J., Zhao, L. X., Geng, X. Y., Li, D. L., Wu, X. W., Zhang, D. K., & Liu, B. R. (2019). A reliable detachable balloon that prevents abdominal cavity contamination during transrectal natural orifice transluminal endoscopic surgery.. Journal of Digestive Diseases. 20(8), 383-390.
- Zhang, J., Zhang, J., Xu, S., Zhang, X., Wang, P., Wu, H., ... Pang, D. a. (2018). Hypoxia-Induced TPM2 Methylation is Associated with Chemoresistance and Poor Prognosis in Breast Cancer.. Cell Physiol Biochem. 45(2), 692-705.
- Lu, Y., Li, X., Liu, S., Zhang, Y., & Zhang, D. (2018). Toll-like receptors and inflammatory bowel disease. Frontiers in Immunology. 9(JAN), 72.
- Xia, B., Shan, M., Wang, J. i., Zhong, Z., Geng, J., He, X., ... Pang, D. a. (2017). Homeobox A11 hypermethylation indicates unfavorable prognosis in breast cancer. ONCOTARGET. 8(6), 9794-9805.
- Sun, L., Li, Y., Jia, X., Wang, Q. i., Li, Y., Hu, M., ... Ren, H. (2017). Neuroprotection by IFN-gamma via astrocyte-secreted IL-6 in acute neuroinflammation. ONCOTARGET. 8(25), 40065-40078.
researcher on
Principal Investigator1
recent teaching activities
- IBST691 Research Credit: Medical Sci Instructor
Email
dekaizhang@tamu.edu
First Name
Dekai
Last Name
Zhang
mailing address
Texas A&M Health Science Center; Ibt-Ciid-Hook; 1201 TAMUS
Houston, TX 77030-3303
USA