overview

Our laboratory is studying the molecular mechanisms of innate immune recognition by identification and analysis of receptors involved in innate immune recognition and activated signaling pathways. We are particularly interested in the recently identified family of Toll-like receptors, which play a critical role in the mounting of innate immune responses. We wish to understand the mechanisms by which TLRs recognize different pathogen associate molecular patterns (PAMPs), as well as the regulatory mechanisms of TLR signal pathways that lead to NF- k B activation. We are also interested in studying the important links between chronic infection, inflammation and cancer by utilizing biochemical as well as whole animal approaches.

education and training
selected publications
Academic Articles37
  • Zhang, J., Zhang, J., Xu, S., Zhang, X., Wang, P., Wu, H., ... Pang, D. a. (2018). Hypoxia-Induced TPM2 Methylation is Associated with Chemoresistance and Poor Prognosis in Breast Cancer.. Cell Physiol Biochem. 45(2), 692-705.
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  • Lu, Y., Li, X., Liu, S., Zhang, Y., & Zhang, D (2018). Toll-like Receptors and Inflammatory Bowel Disease.. Front Immunol. 9(JAN), 72.
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  • Xia, B., Shan, M., Wang, J. i., Zhong, Z., Geng, J., He, X., ... Pang, D. a (2017). Homeobox A11 hypermethylation indicates unfavorable prognosis in breast cancer.. Oncotarget. 8(6), 9794-9805.
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  • Sun, L., Li, Y., Jia, X., Wang, Q. i., Li, Y., Hu, M., ... Ren, H. (2017). Neuroprotection by IFN- via astrocyte-secreted IL-6 in acute neuroinflammation.. Oncotarget. (25),
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  • Zhang, G., Xia, B., Liu, T., Zhang, J., Niu, M., Xu, S., ... Pang, D. a (2016). A High-Quality Biobank Supports Breast Cancer Research in Harbin, China.. Biopreserv Biobank. 14(5), 375-382.
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researcher on
Principal Investigator1
recent teaching activities
Email
dekaizhang@tamu.edu
First Name
Dekai
Last Name
Zhang
mailing address
Texas A&M Health Science Center; Ibt-Ciid-Hook; 1201 TAMUS
Houston, TX 77030-3303
USA