overview

The laboratory focuses on understanding the molecular basis of cell signaling, and how aberrant cell signaling leads to birth defects and causes cancers. Using in vitro cell culture systems and in vivo mouse models, we study how the fibroblast growth factor (FGF) activates its receptor (FF) tyrosine kinase, and how the activated FF transmits the signals to downstream targets and regulates proliferation, differentiation, homeostasis, and function of the cells, as well as in organogenesis and development, including prostate and cardiovascular system development. The laboratory also employs molecular biology, cell biology, and mouse genetic technologies to study how aberrant FGF signals promote tumor initiation, progression, and metastasis. In addition, how environmental factors contribute to tumorigenesis and congenital birth defects by modulating FGF signal intensity and specificity is also under the scope of our research interests.

education and training
selected publications
Academic Articles154
Chapters4
  • Wang, F., Luo, Y., & McKeehan, W. L. (2015). The FGF signaling axis in prostate tumorigenesis. Molecular Oncology: Causes of Cancer and Targets for Treatment. (pp. 190-203). Cambridge University Press.
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  • Wang, F., McKeehan, W. L., Shen, M. M., & Abate-Shen, C. (2011). Genetically engineered mouse models in prostate cancer research. Recent Advances in Prostate Cancer: Basic Science Discoveries and Clinical Advances. (pp. 219-282). World Scientific.
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  • McKeehan, W. L., Wang, F., & Luo, Y. (2010). The fibroblast growth factor (fgf) signaling complex. Handbook of Cell Signaling, 2/e. (pp. 253-259). Elsevier.
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  • Wang, F., & McKeehan, W. L. (2003). The Fibroblast Growth Factor (FGF) Signaling Complex. Handbook of Cell Signaling. (pp. 265-270). Elsevier.
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Conference Papers12
teaching activities
Email
fwang@tamhsc.edu
First Name
Fen
Last Name
Wang
mailing address
2121 w holcombe blvd; Ibt Center For Translational Cancer Research; houston
houston, Texas 77030
USA