Adjei, Isaac individual record
Assistant Professor

Dr. Isaac Adjei's goals are to advance translatable strategies to understand, treat and diagnose cancer, and in the process educate the next generation of scientists. His research focuses on developing drug delivery systems that improve outcomes for advanced-stage cancer. He also studies the mechanisms of tumor immune evasion using three-dimensional tumor models, with the goal of developing novel strategies to reactivate the immune system against tumors.

education and training
selected publications
Academic Articles18
  • Murphy, D. A., Cheng, H., Yang, T., Yan, X., & Adjei, I. M (2021). Reversing Hypoxia with PLGA-Encapsulated Manganese Dioxide Nanoparticles Improves Natural Killer Cell Response to Tumor Spheroids.. Mol Pharm. 18(8), 2935-2946.
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  • Lanier, O. L., Ficarrotta, J. M., Adjei, I., Wable, D., Lewis, C., Nacea, C., ... McFetridge, P (2021). Magnetically Responsive Polymeric Microparticles for the Triggered Delivery of a Complex Mixture of Human Placental Proteins.. Macromol Biosci. 21(1), e2000249-2000249.
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  • Temples, M. N., Adjei, I. M., Nimocks, P. M., Djeu, J., & Sharma, B (2020). Engineered Three-Dimensional Tumor Models to Study Natural Killer Cell Suppression.. ACS Biomater Sci Eng. 6(7), 4179-4199.
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  • Adjei, I. M., Jordan, J., Tu, N., Trinh, T. L., Kandell, W., Wei, S., & Sharma, B (2019). Functional recovery of natural killer cell activity by nanoparticle‐mediated delivery of transforming growth factor beta 2 small interfering RNA. Journal of Interdisciplinary Nanomedicine. 4(4), 98-112.
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  • Kumar, S., Adjei, I. M., Brown, S. B., Liseth, O., & Sharma, B (2019). Manganese dioxide nanoparticles protect cartilage from inflammation-induced oxidative stress.. Biomaterials. 224, 119467-119467.
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  • Adjei, I. M., Plumton, G., & Sharma, B (2016). Oxidative Stress and Biomaterials. Dziubla, T., & Butterfield, D. A. (Eds.), Oxidative Stress and Biomaterials. 89-115. Elsevier.
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Conference Papers3
  • Kumar, S., Adjei, I. M., Brown, S., Liseth, O., & Sharma, B (2019). Manganese dioxide nanoparticles modulate oxidative stress and protect cartilage from interleukin-1β induced degradation. Osteoarthritis and Cartilage. 27, S81-S82.
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  • Kumar, S., Adjei, I. M., & Sharma, B (2018). Manganese dioxide nanoparticles mitigate oxidative stress in osteoarthritic cartilage. Osteoarthritis and Cartilage. 26, S290-S291.
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  • Adjei, I. M., Yang, H., Maldonado-Camargo, L., Dobson, J., Rinaldi, C., Jiang, H., & Sharma, B (2016). Multifunctional nanoparticles for improving function and multimodal tracking of mesenchymal stem cells for osteoarthritis treatment. Osteoarthritis and Cartilage. 24, S462-S463.
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