Chen, Zhilei
individual record
Associate Professor
Positions:
- Associate Professor, Microbial Pathogenesis and Immunology
overview
The Chen Medicinal Protein Lab aims to accelerate the discovery, development and clinical translation of protein therapeutics through innovative protein engineering research. We believe that better medicine enables a higher quality of living, and protein engineers are charged to create the better medicine for today and tomorrow. We are particularly interested in the creation and engineering of affordable protein therapeutics to prevent and treat infectious diseases and cancer.
education and training
- Rockefeller University - (New York, New York, United States), Postdoctoral Training 2008
- Ph.D. in Biophysics, University of Illinois at Urbana Champaign - (Urbana, Illinois, United States) 2006
- B.S. in Physics, East China Normal University - (Shanghai, China) 2000
selected publications
Academic Articles44
- Zeng, Y. u., Woolley, M., Chockalingam, K., Thomas, B., Arora, S., Hook, M., & Chen, Z. (2023). Click display: a rapid and efficient in vitro protein display method for directed evolution.. 51(16), e89-e89.
- Chonira, V., Kwon, Y. D., Gorman, J., Case, J. B., Ku, Z., Simeon, R., ... Chen, Z. (2023). A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins.. 19(3), 284-291.
- Zeng, Y. u., Jiang, M., Robinson, S., Peng, Z., Chonira, V., Simeon, R., ... Chen, Z. (2022). A Multi-Specific DARPin Potently Neutralizes Shiga Toxin 2 via Simultaneous Modulation of Both Toxin Subunits.. Bioengineering. 9(10), 511-511.
- Simeon, R. A., Zeng, Y. u., Chonira, V., Aguirre, A. M., Lasagna, M., Baloh, M., ... Chen, Z. (2022). Correction to: Protease-stable DARPins as promising oral therapeutics.. Protein Engineering Design and Selection. 35, gzac003.
- Woolley, M., & Chen, Z. (2022). A PCR-free rapid protocol for one-pot construction of highly diverse genetic libraries.. PLoS ONE. 17(10), e0276338-e0276338.
Chapters2
- Guan, D., & Chen, Z. (2017). Affinity Purification of Proteins in Tag-Free Form: Split Intein-Mediated Ultrarapid Purification (SIRP). Methods in molecular biology (Clifton, N.J.). SPLIT INTEINS: METHODS AND PROTOCOLS. 1-12. Springer Nature.
- Ramirez, M. A., & Chen, Z. (2017). Split-Intein Triggered Protein Hydrogels.. Methods in molecular biology (Clifton, N.J.). SPLIT INTEINS: METHODS AND PROTOCOLS. 161-171. Springer Nature.
Conference Papers3
- Chen, Z., & Zhao, H. (2005). Directed evolution of homing endonuclease with altered DNA sequence specificity. 8060.
- Chen, Z., & Zhao, H. (2005). Directed evolution of homing endonuclease with novel DNA sequence specificity. 8724.
researcher on
Principal Investigator7
awards and honors
recent teaching activities
- BICH491 Hnr-research Instructor
- BICH491 Research Instructor
- BICH689 Sptp: Biotech & Transl Med Instructor
- BICH691 Research Instructor
- BIMS291 Research Instructor
chaired theses and dissertations
- Chamoun Emanuelli, Ana M (2014-08). Characterization of Viral Entry Inhibitors. (Doctoral Dissertation)
- Ramirez, Miguel Angel (2013-11). Intein Engineering for Protien Hydrogel Synthesis and Protein Purification. (Doctoral Dissertation)
- Klemashevich, Cory (2013-05). Dihydropyridines Inhibit Translation and Early Replication of Hepatitis C Virus. (Master's Thesis)
Email
zchen4@tamu.edu
First Name
Zhilei
Last Name
Chen
mailing address
Texas A&M Health Science Center; Microbial Pathogenesis And Immunology; 1114 TAMUS
College Station, TX 77843-1114
USA