Burgess, Kevin individual record
Professor
Positions:
overview

We use novel strategies Exploring Key Orientations (EKO) that feature datamining to compare simulated preferred conformers of chemotypes we design with key features at protein-protein interfaces. Many chemotype candidates can be screened against one PPI, or one chemotype can be screened against all the PPI interfaces in the PDB. Virtual hit chemotypes are prepared in my lab, then tested against protein-protein interactions of biomedicinal interest using an array of biophysical and cellular assays.

We also design small molecules to target cell surface receptors that are selectively overexpressed in cancer cells. Much or our work has been focused on the TrkC receptor that is particularly important to metastatic breast cancer and melanoma. Going forwards we are interested in expanding the targets to include cell surface receptors that are overexpressed when cancer cells undergo aberrant epithelial to mesenchymal transitions (EMT) to produce circulating tumor cells and cancer stem cells. Much of this work involves design and synthesis of the small molecules for this targeting.

selected publications
Academic Articles266
  • Arancillo, M., Taechalertpaisarn, J., Liang, X., & Burgess, K. (2021). Piptides: New, Easily Accessible Chemotypes For Interactions With Biomolecules. 60(12), 6653-6659.
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  • Tian, C., & Burgess, K. (2021). Flavylium‐ and Silylrhodapolymethines In Excitation Multiplexing. 5(8), 702-704.
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  • Usama, S. M., Zhao, B., & Burgess, K. (2021). Fluorescent kinase inhibitors as probes in cancer. 50(17), 9794-9816.
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  • Usama, S. M., & Burgess, K. (2021). Hows and Whys of Tumor-Seeking Dyes. 54(9), 2121-2131.
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  • Guo, M., Wang, G., Zhao, Y., Li, H., Tang, K., Zhao, Y., & Burgess, K. (2021). Preparation of Nano-ZrO2 powder via a microwave-assisted hydrothermal method. 47(9), 12425-12432.
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Conference Papers91
  • Taechalertpaisarn, J., Araneillo, M. N., Lin, C., Lyu, R., Jiang, Z., Perez, L., Loerger, T., & Burgess, K. (2018). How relevant is secondary structure mimicry in design of small molecules to disrupt protein-protein interfaces?. 255,
  • Wanichacheva, N., Tachapermpon, Y., Praikaew, P., Thavornpradit, S., Charoenpanich, A., Sirirak, J., & Burgess, K. (2018). Near-infrared aza-BODIPY fluorescence probes for selective Cu2+detection and their potential in living cell imaging. 255,
  • Zhao, B., Taechalertpaisarn, J., & Burgess, K. (2018). New photoaffinity labeling module. 255,
in the news
patents
Patents4
chaired theses and dissertations
Email
burgess@tamu.edu
First Name
Kevin
Last Name
Burgess
mailing address
Texas A&M University; Chemistry Department; 3255 TAMU
College Station, TX 77843-3255
USA