Kobayashi, Koichi individual record

The major goal of my laboratory is to understand the function of the innate immune system, particularly in host-pathogen recognition and disease pathophysiology. We elucidated physiological function of Nod2 in the intestine. Our current areas of investigation include: (1) The functions and molecular mechanisms of cytoplasmic NLR family proteins; (2) The role of TLR and NLR proteins in host-pathogen interaction; (3) The pathogenesis of inflammatory diseases caused by dysregulated innate immune responses using molecular and cell biology, as well as gene-targeting approaches.

selected publications
Academic Articles89
  • Kobayashi, K. S. (2013). Shaping Intestinal Bacterial Community by TLR and NLR Signaling. World Rev Nutr Diet. Probiotic Bacteria and Their Effect on Human Health and Well-Being. (pp. 32-42). S. KARGER AG.
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Conference Papers4
  • Vijayan, S., Meissner, T. B., Lee, K., Liu, Y., Downs, I., Sidiq, T., ... Kobayashi, K. S. (2019). Role of NLRC5 and IRF1 in the induction of MHC class I. Journal of Immunology. 202(1),
  • Kobayashi, K. S. (2014). Molecular mechanism of expression of MHC class I molecules. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 34, S133-S133.
  • Kobayashi, K. S. (2012). Molecular mechanism of downregualtion of MHC class I molecules in cancer. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 30, S5-S5.
  • Delhase, M., Yagi, T., Kobayashi, K. S., & Nakanishi, M. (2008). 348 Role of the protein kinase TBK1 in TNFα-induced apoptosis. Cytokine. 43(3), 326-326.
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First Name
Last Name
mailing address
Texas A&M Health Science Center; Microbial Pathogenesis And Immunology; 1114 TAMUS
College Station, TX 77843-1114