Watson, Robert individual record
Assistant Professor

We are interested in the interface between intracellular bacterial pathogens and the hosts they infect. In particular, we study the notorious human pathogen, Mycbacterium tuberculosis, which remains a major global health threat. M. tuberculosis has evolved a variety of specific adaptations to not only survive but also replicate within the harsh environment inside a macrophage. We want to understand the mechanisms by which M. tuberculosis is able to modulate the innate immune response to establish an infection as well as how the host detects and responds to M. tuberculosis.

selected publications
Academic Articles12
  • Weindel, C. G., Martinez, E. L., Zhao, X., Mabry, C. J., Bell, S. L., Vail, K. J., ... Watson, R. O. (2022). Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis.. Cell. 185(17), 3214-3231.e23.
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  • Patrick, K. L., & Watson, R. O. (2021). Mitochondria: Powering the Innate Immune Response to Mycobacterium tuberculosis Infection.. Infect Immun. 89(4),
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  • West, K. O., Scott, H. M., Torres-Odio, S., West, A. P., Patrick, K. L., & Watson, R. O (2019). The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages.. Cell Rep. 29(6), 1594-1609.e5.
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  • Patrick, K. L., Bell, S. L., Weindel, C. G., & Watson, R. O (2019). Exploring the "Multiple-Hit Hypothesis" of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat.. Front Cell Infect Microbiol. 9(MAY), 138.
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  • Patrick, K. L., Wojcechowskyj, J. A., Bell, S. L., Riba, M. N., Jing, T., Talmage, S., ... Watson, R. O. (2018). Quantitative Yeast Genetic Interaction Profiling of Bacterial Effector Proteins Uncovers a Role for the Human Retromer in Salmonella Infection.. Cell Syst. 7(3), 323-338.e6.
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mailing address
Texas A&M Health Science Center; Microbial Pathogenesis And Immunology; 1114 TAMUS
College Station, TX 77843-1114