We are interested in the interface between intracellular bacterial pathogens and the hosts they infect. In particular, we study the notorious human pathogen, Mycbacterium tuberculosis, which remains a major global health threat. M. tuberculosis has evolved a variety of specific adaptations to not only survive but also replicate within the harsh environment inside a macrophage. We want to understand the mechanisms by which M. tuberculosis is able to modulate the innate immune response to establish an infection as well as how the host detects and responds to M. tuberculosis.
- University of California, San Francisco - (San Francisco, California, United States), Postdoctoral Training 2014
- Ph.D. in Microbiology, Yale University - (New Haven, Connecticut, United States) 2006
- M.P.H. in Infectious Diseases, University of California, Berkeley - (Berkeley, California, United States) 2000
- B.S. in Biological Sciences, University of California, Irvine - (Irvine, California, United States) 1997
- West, K. O., Scott, H. M., Torres-Odio, S., West, A. P., Patrick, K. L., & Watson, R. O. (2019). The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages. CELL REPORTS. 29(6), 1594-1609.e5.
- Zhao, B., Du, F., Xu, P., Shu, C., Sankaran, B., Bell, S. L., ... Li, P. (2019). A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. NATURE. 569(7758), 718-722.
- Patrick, K. L., Bell, S. L., Weindel, C. G., & Watson, R. O. (2019). Exploring the “Multiple-Hit Hypothesis” of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat. Front Cell Infect Microbiol. 9(MAY), 138.
- Patrick, K. L., Wojcechowskyj, J. A., Bell, S. L., Riba, M. N., Jing, T., Talmage, S., ... Watson, R. O. (2018). Quantitative Yeast Genetic Interaction Profiling of Bacterial Effector Proteins Uncovers a Role for the Human Retromer in Salmonella Infection. Cell systems. 7(3), 323-+.
- Patrick, K. L., Bell, S. L., & Watson, R. O. (2016). For Better or Worse: Cytosolic DNA Sensing during Intracellular Bacterial Infection Induces Potent Innate Immune Responses. JOURNAL OF MOLECULAR BIOLOGY. 428(17), 3372-3386.