Kuo, Lih individual record
Regents Professor

My research focuses on the physiological and pathophysiological regulation of coronary and retinal microcirculation. In the circulatory system, the amount of blood delivered to each tissue can be regulated by the activity of arterial microvessels (<100 m in diameter). Changes in vascular tone, i.e., constriction or dilation of these microvessels, will decrease or increase blood supply to the tissue, respectively. However, the mechanisms involved in the regulation of vascular tone are not completely understood. Our current research focuses on the regulation of microvascular tone by hemodynamic (e.g., pressure and shear stress), metabolic (e.g., adenosine, osmolarity, K+, pH, pO2) and neural (adrenergic receptors) factors. To have an integrative view on the flow regulation, this basic information are reconstructed using mathematical model and computer simulation technology. This research provides a basic foundation critical to our understanding of blood flow regulation in the microvascular network under normal and disease states.

selected publications
Academic Articles135
  • Davis, M. J., Kuo, L., Chilian, W. M., & Muller, J. M. (2019). Isolated, Perfused Microvessels. Clinically Applied Microcirculation Research. (pp. 435-456). Routledge.
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  • Kuo, L., Thengchaisri, N., & Hein, T. W. (2011). Regulation of Coronary Vasomotor Function by Oxidative Stress. Kimchi, A. (Eds.), New Frontiers in Heart Disease, Proceedings of the 16th World Congress of Heart Disease, International Academy of Cardiology Annual Scientific Sessions. (pp. 103-107). Medimond International Proceedings.
  • Davis, M. J., Hill, M. A., & Kuo, L. (2011). Local Regulation of Microvascular Perfusion. Comprehensive Physiology. John Wiley & Sons, Inc..
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  • Davis, M. J., Hill, M. A., & Kuo, L. (2008). Local Regulation of Microvascular Perfusion. Microcirculation. (pp. 161-284). Elsevier.
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Conference Papers96
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mailing address
Texas A&M Health Science Center; Medical Physiology; 8447 Riverside Parkway
Temple, TX 76504-7105