Kuo, Lih individual record
Regents Professor
Positions:
overview

My research focuses on the physiological and pathophysiological regulation of coronary and retinal microcirculation. In the circulatory system, the amount of blood delivered to each tissue can be regulated by the activity of arterial microvessels (<100 m in diameter). Changes in vascular tone, i.e., constriction or dilation of these microvessels, will decrease or increase blood supply to the tissue, respectively. However, the mechanisms involved in the regulation of vascular tone are not completely understood. Our current research focuses on the regulation of microvascular tone by hemodynamic (e.g., pressure and shear stress), metabolic (e.g., adenosine, osmolarity, K+, pH, pO2) and neural (adrenergic receptors) factors. To have an integrative view on the flow regulation, this basic information are reconstructed using mathematical model and computer simulation technology. This research provides a basic foundation critical to our understanding of blood flow regulation in the microvascular network under normal and disease states.

selected publications
Academic Articles131
  • Hanaguri, J., Yokota, H., Watanabe, M., Yamagami, S., Kushiyama, A., Kuo, L., & Nagaoka, T (2021). Retinal blood flow dysregulation precedes neural retinal dysfunction in type 2 diabetic mice. Scientific Reports. 11(1), 18401.
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  • Thengchaisri, N., Hein, T., Ren, Y. i., & Kuo, L (2021). Activation of Coronary Arteriolar PKCβ2 Impairs Endothelial NO-Mediated Vasodilation: Role of JNK/Rho Kinase Signaling and Xanthine Oxidase Activation. International Journal of Molecular Sciences. 22(18), 9763-9763.
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  • Hanaguri, J., Yokota, H., Watanabe, M., Kuo, L., Yamagami, S., & Nagaoka, T (2020). Longitudinal stability of retinal blood flow regulation in response to flicker stimulation and systemic hyperoxia in mice assessed with laser speckle flowgraphy.. Sci Rep. 10(1), 19796.
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  • Chen, Y., Rosa, R. H., Kuo, L., & Hein, T. W (2020). Hyperglycemia Augments Endothelin-1-Induced Constriction of Human Retinal Venules.. Transl Vis Sci Technol. 9(9), 1-1.
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Chapters14
  • Zhao, M., Xie, W., Hein, T. W., Kuo, L., & Rosa, R. H (2021). Laser-Induced Choroidal Neovascularization in Rats. Methods Mol Biol. Methods in Molecular Biology. 77-85. Springer US.
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  • Xie, W., Zhao, M., Hein, T. W., Kuo, L., & Rosa, R. H (2021). Visualization of Retinal. Methods Mol Biol. Methods in Molecular Biology. 111-117. Springer US.
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  • Davis, M. J., Kuo, L., Chilian, W. M., & Muller, J. M (2019). Isolated, Perfused Microvessels. Clinically Applied Microcirculation Research. 435-456. Routledge.
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  • Davis, M. J., Hill, M. A., & Kuo, L. (2015). Local Regulation of Microvascular Perfusion. Microcirculation. 161-284. Elsevier.
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  • Kuo, L., Thengchaisri, N., & Hein, T. W. (2011). Regulation of Coronary Vasomotor Function by Oxidative Stress. Kimchi, A. (Eds.), New Frontiers in Heart Disease, Proceedings of the 16th World Congress of Heart Disease, International Academy of Cardiology Annual Scientific Sessions. 103-107. Medimond International Proceedings.
Conference Papers96
  • Zhao, M., Xie, W., Chen, W., Hein, T. W., Kuo, L., & Rosa, R. H (2019). Intravitreal stanniocalcin-2 reduces photoreceptor degeneration and improves oscillatory potentials with elevated ocular blood flow in retinitis pigmentosa. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 60(9),
  • Xie, W., Zhao, M., Tsai, S., Su, M., Hein, T. W., Kuo, L., & Rosa, R. H (2019). Stanniocalcin-1 enhances ellipsoid zone intensity and cone function in the P23H rhodopsin transgenic pig. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 60(9),
  • Xie, W., Zhao, M., Tsai, S., Burkes, W. L., Potts, L. B., Xu, W., ... Rosa, R. H (2018). Correlation of spectral domain optical coherence tomography with histology and electron microscopy in the porcine retina.. Exp Eye Res. 177(12), 181-190.
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  • Xie, W., Zhao, M., Tsai, S., Su, M. G., Roddy, G. W., Bradley, P. D., ... Rosa, R. H (2018). Stanniocalcin-1 rescues photoreceptor degeneration in a porcine model of retinitis pigmentosa. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 59(9),
  • Zhao, M., Xie, W., Tsai, S., Su, M. G., Hein, T. W., Kuo, L., & Rosa, R. H (2018). Stanniocalcin-2 preserves retinal function in a rat model of retinitis pigmentosa. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 59(9),
Email
lkuo@tamu.edu
First Name
Lih
Last Name
Kuo
mailing address
Texas A&M Health Science Center; Medical Physiology; 8447 Riverside Parkway
Bryan, TX 77807
USA