Shetty, Ashok individual record
Professor and Associate Director
Positions:
overview

Dr. Ashok K. Shetty's laboratory is interested in developing clinically applicable strategies efficacious for enhancing brain function after injury, disease, or aging. The central areas of investigation are focused on:

o Mechanisms by which intranasally administered stem cell-derived extracellular vesicles (EVs) promote neuroprotection, neuroregeneration, neural plasticity, and alleviate neuroinflammation. The sources of EVs include human bone marrow mesenchymal stem cells (hMSCs), and human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSCs), astrocytes, and microglia. The model systems include traumatic brain injury (TBI), closed head injury (CHI), Aging, Alzheimer's disease (AD) and temporal lobe epilepsy (TLE).

o Mechanisms by which transplanted human neural stem cells or human GABA-ergic precursor cells derived from hiPSCs promote brain repair, and alleviate spontaneous seizures, and cognitive and mood impairments in prototypes of SE, TLE, and TBI.

o Elucidating mechanisms of brain dysfunction and chronic neuroinflammation in prototypes of Gulf War Illness. Developing therapeutic strategies to alleviate neuroinflammation, systemic inflammation, and cognitive and mood impairments in models of GWI.

o Developing clinically feasible strategies for improving brain function in aging and AD models via stimulation of endogenous neural stem cells using drugs and biologics.



Dr. Shetty has received continuous extramural research funding as PI for >25 years from sources such as the NIH, DOD, Dept of Veterans Affairs (VA), and industry. These include five R01 grant awards and an R21 grant award from the NIH; seven CDMRP grant awards from the DOD; five Merit Grant awards and two Research Career Scientist Awards from the VA; and two industry grants. He has also served as Co-I of 8 other DOD grants. Grants from the NIH, DOD, and industry fund Dr. Shetty's current research. Dr. Shetty has authored 181 peer-reviewed publications (147 as senior/first author) and edited a book on Neural Stem Cells in Health and Disease. His work has appeared in many prestigious and high-impact journals. Dr. Shetty has received >16,500 citations for his publications with an h-index of 64. Dr. Shetty has the distinction of serving on two NIH Study Sections and one VA study section as a Chartered Member. Besides, he has served as a member of many other study section panels of the NIH, DOD, VA, and Maryland State Stem Cell Research Fund. Dr. Shetty is Co-Editor-in-Chief of the journal, Aging & Disease and Associate Editor of 6 Neuroscience journals. He is also a Member of the Editorial Board of many prestigious journals, including The Journal of Extracellular Vesicles, Aging Cell, and Stem Cells. Dr. Shetty is a Fellow of the American Society for Neural Transplantation and Repair. Dr. Shetty received the Senior Research Excellence Award in 2021 from the TAMU College of Medicine and is among the "World's Top 2% Scientists" across all scientific fields.

education and training
selected publications
Academic Articles152
  • Shetty, A., Madhu, L., & Kodali, M. (2022). Promise of metformin for preventing age-related cognitive dysfunction. Neural Regeneration Research. 17(3), 503-503.
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  • Wan, Y., Li, X., Slevin, E., Harrison, K., Li, T., Zhang, Y., ... Meng, F. (2022). Endothelial dysfunction in pathological processes of chronic liver disease during aging. The FASEB Journal. 36(1), e22125.
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  • Shetty, A. K., Shetty, P. A., Zanirati, G., & Jin, K. (2021). Further validation of the efficacy of mesenchymal stem cell infusions for reducing mortality in COVID-19 patients with ARDS. npj Regenerative Medicine. 6(1), 53.
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  • Zanirati, G., Provenzi, L., Libermann, L. L., Bizotto, S. C., Ghilardi, I. M., Marinowic, D. R., Shetty, A. K., & Da Costa, J. C. (2021). Stem cell-based therapy for COVID-19 and ARDS: a systematic review. npj Regenerative Medicine. 6(1), 73.
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  • Chakraborty, A., Upadhya, R., Usman, T. A., Shetty, A. K., & Rutkowski, J. M. (2021). Chronic VEGFR-3 signaling preserves dendritic arborization and sensitization under stress. Brain, Behavior, and Immunity. 98, 219-233.
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Chapters2
  • Shetty, A. K., & Hattiangady, B. (2017). Neural Cell Biology. Wang, C., & Slikker, W. (Eds.), Neural Cell Biology. 86-124. CRC Press.
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  • Pradhan, A. A., Shetty, A. K., & Turner, D. A. (2004). Clinical prospects for neural grafting therapy for cortical lesions. Modern Neurosurgery: Clinical Translation of Neuroscience Advances. 17-35.
Conference Papers27
  • Madhu, L. N., Attaluri, S., Kodali, M., Melissari, L., Shuai, B., Upadhya, R., & Shetty, A. K. (2019). Brain Dysfunction in a Model of Gulf War Illness Continues into Middle Age with Elevated Oxidative Stress and Waned Mitochondrial Activity. CELL TRANSPLANTATION. 28(4), 476-477.
  • Upadhya, R., Attaluri, S., Pinson, M., Xu, J., Shuai, B., & Shetty, A. K. (2019). Intranasal Administration of Exosomes from Human iPSC-Derived NSCs Enhances Neural Stem/Progenitor Cell Proliferation and Neurogenesis in the Normal Adult Hippocampus. CELL TRANSPLANTATION. 28(4), 489-489.
  • Atobiloye, M. A., Attaluri, S., Gitai, D., Kodali, M., Kim, D., Prockop, D. J., & Shetty, A. K. (2019). Intranasal Administration of MSCDerived Exosomes Modulate Status Epilepticus Induced Abnormal Plasticity of Newly Born Neurons and Microglial Activation in the Hippocampus. The FASEB Journal. 33(S1), 557.4-557.4.
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  • Kain, J., Petrescu, A., Grant, S., Frampton, G. A., McMillin, M., Wyatt, A., ... DeMorrow, S. (2017). Exposure to gulf war illness-related chemicals increases susceptibility to cholestatic liver injury by enhancing CD11b+macrophage/monocyte infiltration into the liver. HEPATOLOGY. 66, 942A-942A.
Email
akskrs@tamu.edu
First Name
Ashok
Last Name
Shetty
mailing address
Texas A&M Health Science Center; Regenerative Medicine; 1114 TAMUS
Temple, TX 76502-6954
USA