Our laboratory is interested in developing clinically applicable strategies that are efficacious for enhancing brain function after injury, disease or aging. The central areas of investigation include the following: (1) Elucidating mechanisms by which transplanted immature neuronal precursors and neural stem cells (NSCs) and/or GABA-ergic precursor cells derived from embryonic, postnatal and adult brain tissues or human induced pluripotent stem cells (hiPSCs) promote brain repair and ease spontaneous recurrent seizures and cognitive dysfunction in prototypes of status epilepticus, chronic temporal lobe epilepsy (TLE) and traumatic brain injury. (2) Studying mechanisms of brain dysfunction in prototypes of Gulf War Illness and developing treatment strategies to ease cognitive and mood impairments in Gulf War Illness. (3) Developing clinically feasible strategies for improving hippocampus neurogenesis, and memory and mood function in aging and neurological diseases via stimulation of endogenous neural stem/progenitor cells. (4) Analyzing promising neuroprotective compounds and drugs for their usefulness to block chronic epilepsy development after an initial precipitating injury such as status epilepticus or traumatic brain injury (TBI) including mild TBI induced by blast shock waves.
- Ph.D. in Neuroscience, All India Institute of Medical Sciences - (New Delhi, India) 1990
- M.Sc. in Human Anatomy, University of Mysore - (Mysore, India) 1983
- B.Sc. in Zoology, University of Mysore - (Mysore, India) 1980
- Hattiangady, B., Kuruba, R., Shuai, B., Grier, R., & Shetty, A. K. (2020). Hippocampal Neural Stem Cell Grafting after Status Epilepticus Alleviates Chronic Epilepsy and Abnormal Plasticity, and Maintains Better Memory and Mood Function. AGING AND DISEASE. 11(6), 1374-1394.
- Rajesh, S. K., Shetty, A. K., & Upadhya, D. (2020). Patient-derived iPSC modeling of rare neurodevelopmental disorders: Molecular pathophysiology and prospective therapies. Neuroscience & Biobehavioral Reviews. 121, 201-219.
- Bose, D., Saha, P., Mondal, A., Fanelli, B., Seth, R. K., Janulewicz, P., ... Chatterjee, S. (2020). Obesity Worsens Gulf War Illness Symptom Persistence Pathology by Linking Altered Gut Microbiome Species to Long-Term Gastrointestinal, Hepatic, and Neuronal Inflammation in a Mouse Model. Nutrients. 12(9), 2764-2764.
- Upadhya, R., Madhu, L. N., Attaluri, S., Gitaí, D., Pinson, M. R., Kodali, M., ... Shetty, A. K. (2020). Extracellular vesicles from human iPSC‐derived neural stem cells: miRNA and protein signatures, and anti‐inflammatory and neurogenic properties. Journal of Extracellular Vesicles. 9(1), 1809064-1809064.
- Upadhya, R., Zingg, W., Shetty, S., & Shetty, A. K. (2020). Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders. Journal of Controlled Release. 323, 225-239.
- Shetty, A. K., & Hattiangady, B. (2017). Neural stem cells in the adult brain: Altered activity in aging, alzheimer’s disease, mood disorders and epilepsy. Neural Cell Biology. (pp. 86-124). CRC Press.
- Pradhan, A. A., Shetty, A. K., & Turner, D. A. (2004). Clinical prospects for neural grafting therapy for cortical lesions. Modern Neurosurgery: Clinical Translation of Neuroscience Advances. (pp. 17-35).
- Madhu, L. N., Attaluri, S., Kodali, M., Melissari, L., Shuai, B., Upadhya, R., & Shetty, A. K. (2019). Brain Dysfunction in a Model of Gulf War Illness Continues into Middle Age with Elevated Oxidative Stress and Waned Mitochondrial Activity. Cell Transplantation. 28(4), 476-477.
- Upadhya, R., Attaluri, S., Pinson, M., Xu, J., Shuai, B., & Shetty, A. K. (2019). Intranasal Administration of Exosomes from Human iPSC-Derived NSCs Enhances Neural Stem/Progenitor Cell Proliferation and Neurogenesis in the Normal Adult Hippocampus. Cell Transplantation. 28(4), 489-489.
- Atobiloye, M. A., Attaluri, S., Gitai, D., Kodali, M., Kim, D., Prockop, D. J., & Shetty, A. K. (2019). Intranasal Administration of MSC‐Derived Exosomes Modulate Status Epilepticus Induced Abnormal Plasticity of Newly Born Neurons and Microglial Activation in the Hippocampus. FASEB J. 33(S1), 557.4-557.4.
- Upadhya, D., Hattiangady, B., Shuai, B., Bates, A., & Shetty, A. K. (2016). Grafting of GABAergic Progenitors From Human iPSCs Into the Hippocampus After Status Epilepticus Curbs Spontaneous Seizures and Prevents Cognitive, Memory, and Mood Impairments. Cell Transplantation. 25(4), 775-775.
- Kodali, M., Shuai, B., Mishra, V., Attaluri, S., Hattiangady, B., & Shetty, A. K. (2016). Moderate Running Exercise Improves Cognitive, Memory, and Mood Function With Increased Neurogenesis in a Gulf War Illness Model. Cell Transplantation. 25(4), 764-765.
- Curcumin Nanoparticle Therapy for Gulf War Illness awarded by DOD-Army-Medical Research and Materiel Command 2016 - 2020