overview
Our lab investigates the molecular mechanism of protein transport across: (i) the nuclear envelope via the nuclear pore complex (NPC); and (ii) the bacterial cytoplasmic membrane via the Sec(retion) and Tat (twin-arginine translocation) machineries. We seek to understand how large molecules such as proteins are transported across biological membranes without leakage.
education and training
- Brandeis University - (Waltham, Massachusetts, United States), Postdoctoral Training 2001
- University of California, Davis - (Davis, California, United States), Postdoctoral Training 1999
- Ph.D. in Chemistry, California Institute of Technology - (Pasadena, California, United States) 1996
- A.B. in Biochemistry, University of California, Berkeley - (Berkeley, California, United States) 1990
selected publications
Academic Articles632
- Gallagher, A. T., Lee, J. Y., Kathiresan, V., Anderson, J. S., Hoffman, B. M., & Harris, T. D. (2018). A structurally-characterized peroxomanganese(IV) porphyrin from reversible O
2 binding within a metal-organic framework. Chemical Science. 9(6), 1596-1603.
- Chen, J. G., Crooks, R. M., Seefeldt, L. C., Bren, K. L., Morris Bullock, R., Darensbourg, M. Y., ... Schrock, R. R. (2018). Beyond fossil fuel–driven nitrogen transformations. Science (New York, N.Y.). 360(6391),
- Purohit, R., Ross, M. O., Batelu, S., Kusowski, A., Stemmler, T. L., Hoffman, B. M., & Rosenzweig, A. C. (2018). Cu+-specific CopB transporter: Revising p
1B -type ATPase classification. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES. 115(9), 2108-2113.
- Harris, D. F., Lukoyanov, D. A., Shaw, S., Compton, P., Tokmina-Lukaszewska, M., Bothner, B., ... Seefeldt, L. C. (2018). Mechanism of N
2 Reduction Catalyzed by Fe-Nitrogenase Involves Reductive Elimination of H2 . BIOCHEMISTRY. 57(5), 701-710.
- Dong, M., Kathiresan, V., Fenwick, M. K., Torelli, A. T., Zhang, Y., Caranto, J. D., ... Lin, H. (2018). Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis. Science (New York, N.Y.). 359(6381), 1247-1250.
Books1
Chapters2
- Seefeldt, L. C., Dean, D. R., & Hoffman, B. M. (2017). Nitrogenase Mechanism: Electron and Proton Accumulation and N
2 Reduction. RSC Metallobiology. (pp. 274-296).
- Musser, S. M., Stowell, M. H., & Chan, S. I. (1995). Cytochrome c oxidase: chemistry of a molecular machine.. Adv Enzymol Relat Areas Mol Biol. (pp. 79-208).
Conference Papers2
- Chen, L. X., Shelby, M. L., Lestrange, P. J., Jackson, N. E., Haldrup, K., Mara, M. W., ... Li, X. (2016). Imaging ultrafast excited state pathways in transition metal complexes by X-ray transient absorption and scattering using X-ray free electron laser source. FARADAY DISCUSSIONS. 194, 639-658.
- Guo, L., Ellis, D. E., Gubanova, O. V., & Hoffman, B. M. (1995). Ligand substitution effect on optical properties in conducting tetraazaporphyrines. AMORPHOUS AND NANOCRYSTALLINE SILICON SCIENCE AND TECHNOLOGY- 2004. 393, 137-142.
awards and honors
teaching activities
- MEID606 Foundations Of Medicine Ii Instructor
- MSCI601 Contem Top In Adv Cell Bio I Instructor
- MSCI602 Contemp Top In Adv Cell Bio Ii Instructor
- MSCI691 Research Credit: Medical Sci Instructor
chaired theses and dissertations
- Whitaker, Neal William 1982- (2012-12). Deciphering the Mechanism of E. (coli tat Protein Transport: Kinetic Substeps and Cargo Properties. Doctoral Dissertation)
Email
smusser@tamu.edu
First Name
Siegfried
Last Name
Musser
mailing address
Texas A&M Health Science Center; Molecular And Cellular Medicine; 1114 TAMUS
College Station, TX 77843-1114
USA