Musser, Siegfried individual record

Our lab investigates the molecular mechanism of protein transport across: (i) the nuclear envelope via the nuclear pore complex (NPC); and (ii) the bacterial cytoplasmic membrane via the Sec(retion) and Tat (twin-arginine translocation) machineries. We seek to understand how large molecules such as proteins are transported across biological membranes without leakage.

selected publications
Academic Articles632
  • Hamsanathan, S., & Musser, S. M. (2018). The Tat protein transport system: intriguing questions and conundrums.. FEMS Microbiol Lett. 365(12),
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  • Chen, J. G., Crooks, R. M., Seefeldt, L. C., Bren, K. L., Bullock, R. M., Darensbourg, M. Y., ... Schrock, R. R. (2018). Beyond fossil fuel-driven nitrogen transformations.. Science. 360(6391),
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  • Dong, M., Kathiresan, V., Fenwick, M. K., Torelli, A. T., Zhang, Y., Caranto, J. D., ... Lin, H. (2018). Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.. Science. 359(6381), 1247-1250.
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  • Gallagher, A. T., Lee, J. Y., Kathiresan, V., Anderson, J. S., Hoffman, B. M., & Harris, T. D. (2018). A structurally-characterized peroxomanganese(iv) porphyrin from reversible O2 binding within a metal-organic framework.. Chem Sci. 9(6), 1596-1603.
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  • Purohit, R., Ross, M. O., Batelu, S., Kusowski, A., Stemmler, T. L., Hoffman, B. M., & Rosenzweig, A. C. (2018). Cu+-specific CopB transporter: Revising P1B-type ATPase classification.. Proc Natl Acad Sci U S A. 115(9), 2108-2113.
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  • Seefeldt, L. C., Hoffman, B. M., & Dean, D. R. (2009). Mechanism of Mo-dependent nitrogenase.. Annual Reviews.
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  • Seefeldt, L. C., Dean, D. R., & Hoffman, B. M. (2016). CHAPTER 8. Nitrogenase Mechanism: Electron and Proton Accumulation and N2 Reduction. Molybdenum and Tungsten Enzymes. 274-296. Royal Society of Chemistry.
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  • Musser, S. M., Stowell, M. H., & Chan, S. I. (1995). Cytochrome c oxidase: chemistry of a molecular machine.. Advances in Enzymology and Related Areas of Molecular Biology. Advances in Enzymology - and Related Areas of Molecular Biology. 79-208. John Wiley & Sons, Inc..
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Conference Papers2
  • Chen, L. X., Shelby, M. L., Lestrange, P. J., Jackson, N. E., Haldrup, K., Mara, M. W., ... Li, X. (2016). Imaging ultrafast excited state pathways in transition metal complexes by X-ray transient absorption and scattering using X-ray free electron laser source.. Faraday Discuss. 194, 639-658.
  • Guo, L., Ellis, D. E., Gubanova, O. V., & Hoffman, B. M. (1995). Ligand substitution effect on optical properties in conducting tetraazaporphyrines. Materials Research Society Symposium - Proceedings. 393, 137-142.
chaired theses and dissertations
  • Whitaker, Neal William 1982- (2012-12). Deciphering the Mechanism of E. (coli tat Protein Transport: Kinetic Substeps and Cargo Properties. Doctoral Dissertation)
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mailing address
Texas A&M Health Science Center; Molecular And Cellular Medicine; 1114 TAMUS
College Station, TX 77843-1114