overview

The aryl hydrocarbon receptor (AhR) is a nuclear helix-loop-helix transcription factor which forms a ligand-induced nuclear heterodimer with the AhR nuclear translocator (Arnt) protein. Research in this laboratory is focused on the molecular mechanism of crosstalk between the AhR and estrogen receptor (ER) signaling pathways in which the AhR inhibits estrogen-induced gene expression. The antiestrogenic activities of some AhR agonists are also being developed as drugs for clinical treatment of breast and endometrial cancers in women. Research on estrogen-dependent gene expression in various cancer cell lines is focused on analysis of several gene promoters to determine the mechanisms of ERa and ERb action. This includes several genes that are activated through interactions of the ER with Sp1 protein and other DNA-bound transcription factors.

selected publications
Academic Articles934
Chapters9
  • Safe, S., Jin, U. H., & Li, X. (2018). Chemical-Induced Estrogenicity. Veterinary Toxicology: Basic and Clinical Principles: Third Edition. (pp. 805-816).
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  • Safe, S., Lee, S. O., Meng, C., & Zhou, B. (2015). Nr4a orphan receptors as drug targets. Targeted Therapy of Acute Myeloid Leukemi. (pp. 509-528).
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  • Safe, S. (2013). RNA Interference. Brenner's Encyclopedia of Genetics: Second Edition. (pp. 288-289).
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  • Safe, S. H., Khan, S., Wu, F., Li, X., & Sreevalsan, S. (2012). Chemical-induced estrogenicity. Veterinary Toxicology. (pp. 999-1011). Elsevier.
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  • Safe, S., Chadalapaka, G., & Jutooru, I. (2011). AHR-Active Compounds in the Human Diet. The AH Receptor in Biology and Toxicology. (pp. 331-342).
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Conference Papers36
chaired theses and dissertations
Email
s-safe@tamu.edu
First Name
Stephen
Last Name
Safe
mailing address
Texas A&M University; Vet Med - Physiology & Pharmacology; 4466 TAMU
College Station, TX 77843-4466
USA