overview

My major research goals are to understand the molecular pathophysiology and develop novel therapeutic strategies for epilepsy, with an emphasis on neurosteroids and GABA inhibition in the brain. Neurosteroids are steroids synthesized locally within the brain that rapidly change neural excitability by non-genomic mechanisms, principally via postsynaptic GABAA receptors that play critical role in epilepsy. Current work in his lab is focused on uncovering molecular mechanisms of neurosteroids in epilepsy and brain disorders, and testing the efficacy of mechanism-based, rationale therapeutic strategies for epilepsy and epileptogenesis. Reddy lab is utilizing multidisciplinary approaches such as pharmacological, molecular, electrophysiological (patch-clamp), mass spectrometry, and transgenic mouse models in research projects.

education and training
selected publications
Academic Articles139
Books2
Chapters6
  • Reddy, D. S. (2017). Perimenstrual Seizures and Neurosteroid Withdrawal. Models of Seizures and Epilepsy: Second Edition. (pp. 933-940). Elsevier.
    doi badge
  • Sohrabji, F., Jane Welsh, C., & Reddy, D. S. (2015). Sex Differences in Neurological Diseases. Sex Differences in the Central Nervous System. (pp. 297-323). Elsevier.
    doi badge
  • Reddy, D. S. (2013). Neurosteroid Influences on Neuronal Excitability. Epilepsy in Women. (pp. 23-40). John Wiley & Sons.
    doi badge
  • Reddy, D. S., & Rogawski, M. A. (2010). Neurosteroid replacement therapy for catamenial epilepsy. Epilepsy: Mechanisms, Models, and Translational Perspectives. (pp. 501-513). CRC Press.
    doi badge
  • Adithan, C., & Reddy, D. S. (2009). Funding opportunities in biomedical sciences and preparing a successful grant application. Biomedical Research: From Ideation to Publication.
Conference Papers11
patents
Patents1
chaired theses and dissertations
Email
reddy@medicine.tamhsc.edu
First Name
Samba
Last Name
Reddy
mailing address
Texas A&M Health Science Center; Neuroscience & Experimental Therapeutics; 1359 TAMUS
Bryan, TX 77807-3260
USA