Scholars

Reddy, Samba

Professor

Positions:

Professor, Neuroscience and Experimental Therapeutics, College of Medicine

Research Areas:

Epilepsy, Brain--Diseases, Neurosciences

UN Sustainable Development Goals:

Single Page Bio

Profile Summary

reddy@medicine.tamhsc.edu

1 979 436 0324

Co-author Network

Map of Science

Co-investigator Network

Websites

Dr. Reddy Faculty Website

ORCID

0000-0003-2735-9550

UN Sustainable Development Goals:

Research Areas:

Epilepsy, Brain--Diseases, Neurosciences

overview

My major research goals are to understand the molecular pathophysiology and develop novel therapeutic strategies for epilepsy, with an emphasis on neurosteroids and GABA inhibition in the brain. Neurosteroids are steroids synthesized locally within the brain that rapidly change neural excitability by non-genomic mechanisms, principally via postsynaptic GABAA receptors that play critical role in epilepsy. Current work in his lab is focused on uncovering molecular mechanisms of neurosteroids in epilepsy and brain disorders, and testing the efficacy of mechanism-based, rationale therapeutic strategies for epilepsy and epileptogenesis. Reddy lab is utilizing multidisciplinary approaches such as pharmacological, molecular, electrophysiological (patch-clamp), mass spectrometry, and transgenic mouse models in research projects.

education and training

National Institute of Neurological Disorders and Stroke - (Bethesda, Maryland, United States), Postdoctoral Training 2001
Ph.D. in Pharmacology, Panjab University - (Chandigarh, Chandigarh, India) 1998
Pharm.M. in Pharmaceutical Sciences, Panjab University - (Chandigarh, Chandigarh, India) 1994
B.Pharm. in Pharmaceutical Sciences, Kakatiya University - (Warangal, India) 1992

selected publications

Academic Articles144

Reddy, D. S. (2022). Neurosteroid replacement therapy for catamenial epilepsy, postpartum depression and neuroendocrine disorders in women. Journal of Neuroendocrinology. 34(2), e13028.
Reddy, D. S., Zaayman, M., Kuruba, R., & Wu, X. (2021). Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman.. Neuropharmacology. 191, 108571-108571.
Reddy, D. S., Thompson, W., & Calderara, G. (2021). Molecular mechanisms of sex differences in epilepsy and seizure susceptibility in chemical, genetic and acquired epileptogenesis.. Neurosci Lett. 750, 135753-135753.
Reddy, S. D., Wu, X., Kuruba, R., Sridhar, V., & Reddy, D. S. (2020). Magnetic resonance imaging analysis of long-term neuropathology after exposure to the nerve agent soman: correlation with histopathology and neurological dysfunction.. Ann N Y Acad Sci. 1480(1), 116-135.
Rees, K. A., Halawa, A. A., Consuegra-Garcia, D., Golub, V. M., Clossen, B. L., Tan, A. M., ... Winzer-Serhan, U. H. (2020). Molecular, physiological and behavioral characterization of the heterozygous Df[h15q13]/+ mouse model associated with the human 15q13.3 microdeletion syndrome.. Brain Res. 1746, 147024-147024.

Books2

Reddy, D. S. (2012). Pharmacy Quiz GPAT Pharmacy Competitive Exams. PBS Publishers.
Reddy, D. S. (2010). Pharmacy Quiz - A Handbook for Pharmacy Competitive Exams. PharmaMed Press.

Chapters7

Golub, V., & Reddy, D. S. (2021). Cannabidiol Therapy for Refractory Epilepsy and Seizure Disorders.. MATHEMATICAL MODELLING IN EXPERIMENTAL NUTRITION. Cannabinoids and Neuropsychiatric Disorders. 93-110. Springer International Publishing.
Reddy, D. S. (2019). HORMONES AND GENDER | Steroid Hormones and Sex Differences in Seizure Susceptibility. Encyclopedia of Basic Epilepsy Research. 526-533. Elsevier.
Reddy, D. S. (2017). Perimenstrual Seizures and Neurosteroid Withdrawal. Models of Seizures and Epilepsy. 933-940. Elsevier.
Sohrabji, F., Welsh, C. J., & Reddy, D. S. (2016). Sex Differences in Neurological Diseases. Sex Differences in the Central Nervous System. 297-323. Elsevier.
Reddy, D. S. (2013). Neurosteroid Influences on Neuronal Excitability. Epilepsy in Women. 23-40. JOhn Wiley & Sons.