My major research goals are to understand the molecular pathophysiology and develop novel therapeutic strategies for epilepsy, with an emphasis on neurosteroids and GABA inhibition in the brain. Neurosteroids are steroids synthesized locally within the brain that rapidly change neural excitability by non-genomic mechanisms, principally via postsynaptic GABAA receptors that play critical role in epilepsy. Current work in his lab is focused on uncovering molecular mechanisms of neurosteroids in epilepsy and brain disorders, and testing the efficacy of mechanism-based, rationale therapeutic strategies for epilepsy and epileptogenesis. Reddy lab is utilizing multidisciplinary approaches such as pharmacological, molecular, electrophysiological (patch-clamp), mass spectrometry, and transgenic mouse models in research projects.
- National Institute of Neurological Disorders and Stroke - (Bethesda, Maryland, United States), Postdoctoral Training 2001
- Ph.D. in Pharmacology, Panjab University - (Chandigarh, Chandigarh, India) 1998
- Pharm.M. in Pharmaceutical Sciences, Panjab University - (Chandigarh, Chandigarh, India) 1994
- B.Pharm. in Pharmaceutical Sciences, Kakatiya University - (Warangal, India) 1992
Academic Articles197
- Reddy, D. S. (2024). Progress and Challenges in Developing Medical Countermeasures for Chemical, Biological, Radiological, and Nuclear Threat Agents.. Journal of Pharmacology and Experimental Therapeutics. 388(2), 260-267.
- Reddy, D. S. (2024). Special Section on Medical Countermeasures, From Bench to Battlefield: Translating Experimental Therapies for Effective Combat Against Chemical Threats-Editorial.. Journal of Pharmacology and Experimental Therapeutics. 388(2), 257-259.
- Reddy, D. S. (2024). Progress and Challenges in Developing Medical Countermeasures for Chemical, Biological, Radiological, and Nuclear Threat Agents (Special Issue on Medical Countermeasures -Commentary).. Journal of Pharmacology and Experimental Therapeutics. JPET-COM-2023-002040.
- Reddy, D. S., Singh, T., Ramakrishnan, S., Huber, M., & Wu, X. (2023). Neuroprotectant Activity of Novel Water-Soluble Synthetic Neurosteroids on Organophosphate Intoxication and Status Epilepticus-induced Long-term Neurological Dysfunction, Neurodegeneration and Neuroinflammation.. Journal of Pharmacology and Experimental Therapeutics. jpet-ar-2023-001819.
- Ramakrishnan, S., Singh, T., & Reddy, D. S. (2023). Protective Activity of Novel Hydrophilic Synthetic Neurosteroids on Organophosphate Status Epilepticus-induced Chronic Epileptic Seizures, Non-Convulsive Discharges, High-Frequency Oscillations and Electrographic Ictal Biomarkers.. Journal of Pharmacology and Experimental Therapeutics. jpet-ar-2023-001817.
Books2
Chapters18
- Reddy, D. S. (2023). Chapter 20 Advances in targeted therapy of organophosphate neurotoxicity and chemical warfare nerve agents. Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects. 489-500. Elsevier.
- Reddy, D. S. (2023). Chapter 21 Molecular mechanisms of sex differences in epilepsy. Principles of Gender-Specific Medicine. 347-362. Elsevier.
- Reddy, D. S., Thompson, W., & Calderara, G. (2022). Does Stress Trigger Seizures? Evidence from Experimental Models.. Current topics in behavioral neurosciences. Psychiatric and Behavioral Aspects of Epilepsy. 41-64. Springer Nature.
- Golub, V., & Reddy, D. S. (2021). Cannabidiol Therapy for Refractory Epilepsy and Seizure Disorders.. Advances in Experimental Medicine and Biology. CANNABINOIDS AND NEUROPSYCHIATRIC DISORDERS. 93-110. Springer Nature.
- Reddy, D. S. (2020). Brain structural and neuroendocrine basis of sex differences in epilepsy.. Handbook of Clinical Neurology. Sex Differences in Neurology and Psychiatry. 223-233. Elsevier.
Conference Papers12
- Carver, C., Wu, X., Murchison, D., Griffith, W., & Reddy, D. S. (2012). Ovarian cycle-related effects of neurosteroids on GABA-A receptor-mediated phasic and tonic currents in the hippocampus. The FASEB Journal. 26(S1), 1048.3-1048.3.
- Wu, X., Muthuchamy, M., & Reddy, D. S. (2012). Atomic force microscopy study of ECM-integrin modulation of neuroplasticity in the hippocampal dentate granule cells in epilepsy. The FASEB Journal. 26(S1), 672.8-672.8.
- Saraf, M., Briyal, S., & Reddy, D. S. (2009). ANTIEPILEPTOGENIC ACTIVITY OF PROGESTERONE IN WILD-TYPE AND PROGESTERONE RECEPTOR KNOCKOUT MICE. EPILEPSIA. 50, 126-126.
- Reddy, D. S. (2009). GENDER DIFFERENCES IN ANTISEIZURE SENSITIVITY OF NEUROSTEROIDS IN THE PILOCARPINE MODEL OF STATUS EPILEPTICUS. EPILEPSIA. 50, 126-126.
- Reddy, D. S., & Rogawski, M. A. (2009). Protective Efficacy and Potency of Neuroactive Steroids and Benzodiazepines in the Amygdala Kindling Model of Epilepsy. The FASEB Journal. 23(S1), 947.6-947.6.
- Texas A&M Neuroscientists Discover New Therapy For Refractory Epilepsy Texas A&M Today June 24, 2020
Patents3
- Reddy, D. S. (2019). Method of treating organophosphate intoxication by administration of neurosteroids.
- Reddy, D. S. (2019). Method of treating organophosphate intoxication by administration of neurosteroids.
Principal Investigator5
- Neurosteroid Therapy for Gulf War Illness awarded by U.S. Army Medical Research Acquisition Activity 2019 - 2021
- Epigenetic mechanisms of post-traumatic epilepsy awarded by DOD-Army-Medical Research and Materiel Command 2016 - 2020
- Editor of Epilepsy Currents conferred by American Epilepsy Society - (Chicago, Illinois, United States) - This is ongoing. 2014
- BICH491 Hnr-research Instructor
- BICH491 Research Instructor
- BMEN491 Hnr-research Instructor
- BMEN491 Research Instructor
- BMEN691 Research Instructor
- Carver, Chase M (2015-04). Role of Delta Subunit-Containing GABAA Receptors in Hippocampus Tonic Inhibition and Epileptogenesis within Transgenic Mouse Models. (Doctoral Dissertation)