Scholars

My major research goals are to understand the molecular pathophysiology and develop novel therapeutic strategies for epilepsy, with an emphasis on neurosteroids and GABA inhibition in the brain. Neurosteroids are steroids synthesized locally within the brain that rapidly change neural excitability by non-genomic mechanisms, principally via postsynaptic GABAA receptors that play critical role in epilepsy. Current work in his lab is focused on uncovering molecular mechanisms of neurosteroids in epilepsy and brain disorders, and testing the efficacy of mechanism-based, rationale therapeutic strategies for epilepsy and epileptogenesis. Reddy lab is utilizing multidisciplinary approaches such as pharmacological, molecular, electrophysiological (patch-clamp), mass spectrometry, and transgenic mouse models in research projects.

education and training

National Institute of Neurological Disorders and Stroke - (Bethesda, Maryland, United States), Postdoctoral Training 2001
Ph.D. in Pharmacology, Panjab University - (Chandigarh, Chandigarh, India) 1998
Pharm.M. in Pharmaceutical Sciences, Panjab University - (Chandigarh, Chandigarh, India) 1994
B.Pharm. in Pharmaceutical Sciences, Kakatiya University - (Warangal, India) 1992

selected publications

Academic Articles139

Chuang, S., & Reddy, D. S. (2020). Isobolographic Analysis of Antiseizure Activity of the GABA-A Receptor-Modulating Synthetic Neurosteroids Brexanolone and Ganaxolone with Tiagabine and Midazolam. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 372(3), jpet.119.261735-298.
Reddy, S. D., Wu, X., Kuruba, R., Sridhar, V., & Reddy, D. S. (2020). Magnetic resonance imaging analysis of long-term neuropathology after exposure to the nerve agent soman: correlation with histopathology and neurological dysfunction.. TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY.
Reddy, D. S., Perumal, D., Golub, V., Habib, A., Kuruba, R., & Wu, X. (2020). Phenobarbital as alternate anticonvulsant for organophosphate‐induced benzodiazepine‐refractory status epilepticus and neuronal injury. Epilepsia Open. 5(2), 198-212.
Reddy, D. S. (2019). An enigmatic role of tonic inhibition in gabapentin therapy. EBioMedicine. 42, 14-15.
Reddy, D. S., Carver, C. M., Clossen, B., & Wu, X. (2019). Extrasynaptic γ‐aminobutyric acid type A receptor–mediated sex differences in the antiseizure activity of neurosteroids in status epilepticus and complex partial seizures. Epilepsia. 60(4), 730-743.

Books2

Reddy, D. S. (2012). Pharmacy Quiz GPAT Pharmacy Competitive Exams. PBS Publishers.
Reddy, D. S. (2010). Pharmacy Quiz - A Handbook for Pharmacy Competitive Exams. PharmaMed Press.

Chapters6

Reddy, D. S. (2017). Perimenstrual Seizures and Neurosteroid Withdrawal. Models of Seizures and Epilepsy: Second Edition. (pp. 933-940). Elsevier.
Sohrabji, F., Jane Welsh, C., & Reddy, D. S. (2015). Sex Differences in Neurological Diseases. Sex Differences in the Central Nervous System. (pp. 297-323). Elsevier.
Reddy, D. S. (2013). Neurosteroid Influences on Neuronal Excitability. Epilepsy in Women. (pp. 23-40). John Wiley & Sons.
Reddy, D. S., & Rogawski, M. A. (2010). Neurosteroid replacement therapy for catamenial epilepsy. Epilepsy: Mechanisms, Models, and Translational Perspectives. (pp. 501-513). CRC Press.
Adithan, C., & Reddy, D. S. (2009). Funding opportunities in biomedical sciences and preparing a successful grant application. Biomedical Research: From Ideation to Publication.