overview

My major research goals are to understand the molecular pathophysiology and develop novel therapeutic strategies for epilepsy, with an emphasis on neurosteroids and GABA inhibition in the brain. Neurosteroids are steroids synthesized locally within the brain that rapidly change neural excitability by non-genomic mechanisms, principally via postsynaptic GABAA receptors that play critical role in epilepsy. Current work in his lab is focused on uncovering molecular mechanisms of neurosteroids in epilepsy and brain disorders, and testing the efficacy of mechanism-based, rationale therapeutic strategies for epilepsy and epileptogenesis. Reddy lab is utilizing multidisciplinary approaches such as pharmacological, molecular, electrophysiological (patch-clamp), mass spectrometry, and transgenic mouse models in research projects.

education and training
selected publications
Academic Articles144
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  • Reddy, D. S., Zaayman, M., Kuruba, R., & Wu, X. (2021). Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman.. Neuropharmacology. 191, 108571-108571.
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  • Reddy, D. S., Thompson, W., & Calderara, G. (2021). Molecular mechanisms of sex differences in epilepsy and seizure susceptibility in chemical, genetic and acquired epileptogenesis.. Neurosci Lett. 750, 135753-135753.
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  • Rees, K. A., Halawa, A. A., Consuegra-Garcia, D., Golub, V. M., Clossen, B. L., Tan, A. M., ... Winzer-Serhan, U. H. (2020). Molecular, physiological and behavioral characterization of the heterozygous Df[h15q13]/+ mouse model associated with the human 15q13.3 microdeletion syndrome.. Brain Res. 1746, 147024-147024.
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Books2
  • Reddy, D. S. (2012). Pharmacy Quiz GPAT Pharmacy Competitive Exams. PBS Publishers.
  • Reddy, D. S. (2010). Pharmacy Quiz - A Handbook for Pharmacy Competitive Exams. PharmaMed Press.
Chapters7
  • Golub, V., & Reddy, D. S. (2021). Cannabidiol Therapy for Refractory Epilepsy and Seizure Disorders.. MATHEMATICAL MODELLING IN EXPERIMENTAL NUTRITION. Cannabinoids and Neuropsychiatric Disorders. 93-110. Springer International Publishing.
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  • Reddy, D. S. (2019). HORMONES AND GENDER | Steroid Hormones and Sex Differences in Seizure Susceptibility. Encyclopedia of Basic Epilepsy Research. 526-533. Elsevier.
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  • Reddy, D. S. (2017). Perimenstrual Seizures and Neurosteroid Withdrawal. Models of Seizures and Epilepsy. 933-940. Elsevier.
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  • Sohrabji, F., Welsh, C. J., & Reddy, D. S. (2016). Sex Differences in Neurological Diseases. Sex Differences in the Central Nervous System. 297-323. Elsevier.
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  • Reddy, D. S. (2013). Neurosteroid Influences on Neuronal Excitability. Epilepsy in Women. 23-40. JOhn Wiley & Sons.
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Conference Papers12
  • Carver, C., Wu, X., Murchison, D., Griffith, W., & Reddy, D. S. (2012). Ovarian cyclerelated effects of neurosteroids on GABAA receptormediated phasic and tonic currents in the hippocampus. The FASEB Journal. 26(S1), 1048.3-1048.3.
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  • Saraf, M., Briyal, S., & Reddy, D. S. (2009). ANTIEPILEPTOGENIC ACTIVITY OF PROGESTERONE IN WILD-TYPE AND PROGESTERONE RECEPTOR KNOCKOUT MICE. EPILEPSIA. 50, 126-126.
patents
Patents2
chaired theses and dissertations
Email
reddy@medicine.tamhsc.edu
First Name
Samba
Last Name
Reddy
mailing address
Texas A&M Health Science Center; Neuroscience & Experimental Therapeutics; 1359 TAMUS
Bryan, TX 77807-3260
USA