overview

My major research goals are to understand the molecular pathophysiology and develop novel therapeutic strategies for epilepsy, with an emphasis on neurosteroids and GABA inhibition in the brain. Neurosteroids are steroids synthesized locally within the brain that rapidly change neural excitability by non-genomic mechanisms, principally via postsynaptic GABAA receptors that play critical role in epilepsy. Current work in his lab is focused on uncovering molecular mechanisms of neurosteroids in epilepsy and brain disorders, and testing the efficacy of mechanism-based, rationale therapeutic strategies for epilepsy and epileptogenesis. Reddy lab is utilizing multidisciplinary approaches such as pharmacological, molecular, electrophysiological (patch-clamp), mass spectrometry, and transgenic mouse models in research projects.

education and training
selected publications
Academic Articles197
  • Reddy, D. S. (2024). Progress and Challenges in Developing Medical Countermeasures for Chemical, Biological, Radiological, and Nuclear Threat Agents.. Journal of Pharmacology and Experimental Therapeutics. 388(2), 260-267.
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  • Reddy, D. S., Singh, T., Ramakrishnan, S., Huber, M., & Wu, X. (2023). Neuroprotectant Activity of Novel Water-Soluble Synthetic Neurosteroids on Organophosphate Intoxication and Status Epilepticus-induced Long-term Neurological Dysfunction, Neurodegeneration and Neuroinflammation.. Journal of Pharmacology and Experimental Therapeutics. jpet-ar-2023-001819.
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Books2
  • Reddy, D. S. (2012). Pharmacy Quiz GPAT Pharmacy Competitive Exams. PBS Publishers.
  • Reddy, D. S. (2010). Pharmacy Quiz - A Handbook for Pharmacy Competitive Exams. PharmaMed Press.
Chapters18
  • Reddy, D. S. (2023). Chapter 20 Advances in targeted therapy of organophosphate neurotoxicity and chemical warfare nerve agents. Sensing of Deadly Toxic Chemical Warfare Agents, Nerve Agent Simulants, and their Toxicological Aspects. 489-500. Elsevier.
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  • Reddy, D. S. (2023). Chapter 21 Molecular mechanisms of sex differences in epilepsy. Principles of Gender-Specific Medicine. 347-362. Elsevier.
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  • Reddy, D. S., Thompson, W., & Calderara, G. (2022). Does Stress Trigger Seizures? Evidence from Experimental Models.. Current topics in behavioral neurosciences. Psychiatric and Behavioral Aspects of Epilepsy. 41-64. Springer Nature.
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  • Golub, V., & Reddy, D. S. (2021). Cannabidiol Therapy for Refractory Epilepsy and Seizure Disorders.. Advances in Experimental Medicine and Biology. CANNABINOIDS AND NEUROPSYCHIATRIC DISORDERS. 93-110. Springer Nature.
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  • Reddy, D. S. (2020). Brain structural and neuroendocrine basis of sex differences in epilepsy.. Handbook of Clinical Neurology. Sex Differences in Neurology and Psychiatry. 223-233. Elsevier.
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Conference Papers12
  • Carver, C., Wu, X., Murchison, D., Griffith, W., & Reddy, D. S. (2012). Ovarian cycle-related effects of neurosteroids on GABA-A receptor-mediated phasic and tonic currents in the hippocampus. The FASEB Journal. 26(S1), 1048.3-1048.3.
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  • Wu, X., Muthuchamy, M., & Reddy, D. S. (2012). Atomic force microscopy study of ECM-integrin modulation of neuroplasticity in the hippocampal dentate granule cells in epilepsy. The FASEB Journal. 26(S1), 672.8-672.8.
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  • Saraf, M., Briyal, S., & Reddy, D. S. (2009). ANTIEPILEPTOGENIC ACTIVITY OF PROGESTERONE IN WILD-TYPE AND PROGESTERONE RECEPTOR KNOCKOUT MICE. EPILEPSIA. 50, 126-126.
  • Reddy, D. S., & Rogawski, M. A. (2009). Protective Efficacy and Potency of Neuroactive Steroids and Benzodiazepines in the Amygdala Kindling Model of Epilepsy. The FASEB Journal. 23(S1), 947.6-947.6.
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patents
Patents3
recent teaching activities
chaired theses and dissertations
Email
reddy@medicine.tamhsc.edu
First Name
Samba
Last Name
Reddy
mailing address
Texas A&M Health Science Center; Neuroscience & Experimental Therapeutics; 1359 TAMUS
Bryan, TX 77807-3260
USA