Scholars

Reddy, Samba

Professor

Positions:

Professor, Neuroscience and Experimental Therapeutics, College of Medicine

Research Areas:

Epilepsy, Brain--Diseases, Neurosciences

Single Page Bio

reddy@medicine.tamhsc.edu

1 979 436 0324

Co-author Network

Map of Science

Co-investigator Network

Websites

Dr. Reddy Faculty Website

ORCID

0000-0003-2735-9550

Research Areas:

Epilepsy, Brain--Diseases, Neurosciences

overview

My major research goals are to understand the molecular pathophysiology and develop novel therapeutic strategies for epilepsy, with an emphasis on neurosteroids and GABA inhibition in the brain. Neurosteroids are steroids synthesized locally within the brain that rapidly change neural excitability by non-genomic mechanisms, principally via postsynaptic GABAA receptors that play critical role in epilepsy. Current work in his lab is focused on uncovering molecular mechanisms of neurosteroids in epilepsy and brain disorders, and testing the efficacy of mechanism-based, rationale therapeutic strategies for epilepsy and epileptogenesis. Reddy lab is utilizing multidisciplinary approaches such as pharmacological, molecular, electrophysiological (patch-clamp), mass spectrometry, and transgenic mouse models in research projects.

education and training

National Institute of Neurological Disorders and Stroke - (Bethesda, Maryland, United States), Postdoctoral Training 2001
Ph.D. in Pharmacology, Panjab University - (Chandigarh, Chandigarh, India) 1998
Pharm.M. in Pharmaceutical Sciences, Panjab University - (Chandigarh, Chandigarh, India) 1994
B.Pharm. in Pharmaceutical Sciences, Kakatiya University - (Warangal, India) 1992

selected publications

Academic Articles142

Reddy, D. S., Zaayman, M., Kuruba, R., & Wu, X. (2021). Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman. Neuropharmacology. 108571-108571.
Christian, C. A., Reddy, D. S., Maguire, J., & Forcelli, P. A. (2020). Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies. Pharmacological Reviews. 72(4), 767-800.
Reddy, S. D., Wu, X., Kuruba, R., Sridhar, V., & Reddy, D. S. (2020). Magnetic resonance imaging analysis of long‐term neuropathology after exposure to the nerve agent soman: correlation with histopathology and neurological dysfunction. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1480(1), 116-135.
Rees, K. A., Halawa, A. A., Consuegra-Garcia, D., Golub, V. M., Clossen, B. L., Tan, A. M., ... Winzer-Serhan, U. H. (2020). Molecular, physiological and behavioral characterization of the heterozygous Df[h15q13]/+ mouse model associated with the human 15q13.3 microdeletion syndrome. Brain Research. 1746, 147024-147024.
Reddy, D. S., Perumal, D., Golub, V., Habib, A., Kuruba, R., & Wu, X. (2020). Phenobarbital as alternate anticonvulsant for organophosphate‐induced benzodiazepine‐refractory status epilepticus and neuronal injury. Epilepsia Open. 5(2), 198-212.

Books2

Reddy, D. S. (2012). Pharmacy Quiz GPAT Pharmacy Competitive Exams. PBS Publishers.
Reddy, D. S. (2010). Pharmacy Quiz - A Handbook for Pharmacy Competitive Exams. PharmaMed Press.

Chapters6

Reddy, D. S. (2017). Perimenstrual Seizures and Neurosteroid Withdrawal. Models of Seizures and Epilepsy: Second Edition. (pp. 933-940). Elsevier.
Sohrabji, F., Jane Welsh, C., & Reddy, D. S. (2015). Sex Differences in Neurological Diseases. Sex Differences in the Central Nervous System. (pp. 297-323). Elsevier.
Reddy, D. S. (2013). Neurosteroid Influences on Neuronal Excitability. Epilepsy in Women. (pp. 23-40). JOhn Wiley & Sons.
Reddy, D. S., & Rogawski, M. A. (2010). Neurosteroid replacement therapy for catamenial epilepsy. Epilepsy: Mechanisms, Models, and Translational Perspectives. (pp. 501-513). CRC Press.
Adithan, C., & Reddy, D. S. (2009). Funding opportunities in biomedical sciences and preparing a successful grant application. Biomedical Research: From Ideation to Publication.