My major research goals are to understand the molecular pathophysiology and develop novel therapeutic strategies for epilepsy, with an emphasis on neurosteroids and GABA inhibition in the brain. Neurosteroids are steroids synthesized locally within the brain that rapidly change neural excitability by non-genomic mechanisms, principally via postsynaptic GABAA receptors that play critical role in epilepsy. Current work in his lab is focused on uncovering molecular mechanisms of neurosteroids in epilepsy and brain disorders, and testing the efficacy of mechanism-based, rationale therapeutic strategies for epilepsy and epileptogenesis. Reddy lab is utilizing multidisciplinary approaches such as pharmacological, molecular, electrophysiological (patch-clamp), mass spectrometry, and transgenic mouse models in research projects.
- National Institute of Neurological Disorders and Stroke - (Bethesda, Maryland, United States), Postdoctoral Training 2001
- Ph.D. in Pharmacology, Panjab University - (Chandigarh, Chandigarh, India) 1998
- Pharm.M. in Pharmaceutical Sciences, Panjab University - (Chandigarh, Chandigarh, India) 1994
- B.Pharm. in Pharmaceutical Sciences, Kakatiya University - (Warangal, India) 1992
Academic Articles144
- Reddy, D. S. (2022). Neurosteroid replacement therapy for catamenial epilepsy, postpartum depression and neuroendocrine disorders in women. Journal of Neuroendocrinology. 34(2), e13028.
- Reddy, D. S., Zaayman, M., Kuruba, R., & Wu, X. (2021). Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman.. Neuropharmacology. 191, 108571-108571.
- Reddy, D. S., Thompson, W., & Calderara, G. (2021). Molecular mechanisms of sex differences in epilepsy and seizure susceptibility in chemical, genetic and acquired epileptogenesis.. Neurosci Lett. 750, 135753-135753.
- Reddy, S. D., Wu, X., Kuruba, R., Sridhar, V., & Reddy, D. S. (2020). Magnetic resonance imaging analysis of long-term neuropathology after exposure to the nerve agent soman: correlation with histopathology and neurological dysfunction.. Ann N Y Acad Sci. 1480(1), 116-135.
- Rees, K. A., Halawa, A. A., Consuegra-Garcia, D., Golub, V. M., Clossen, B. L., Tan, A. M., ... Winzer-Serhan, U. H. (2020). Molecular, physiological and behavioral characterization of the heterozygous Df[h15q13]/+ mouse model associated with the human 15q13.3 microdeletion syndrome.. Brain Res. 1746, 147024-147024.
Books2
Chapters7
- Golub, V., & Reddy, D. S. (2021). Cannabidiol Therapy for Refractory Epilepsy and Seizure Disorders.. MATHEMATICAL MODELLING IN EXPERIMENTAL NUTRITION. Cannabinoids and Neuropsychiatric Disorders. 93-110. Springer International Publishing.
- Reddy, D. S. (2019). HORMONES AND GENDER | Steroid Hormones and Sex Differences in Seizure Susceptibility. Encyclopedia of Basic Epilepsy Research. 526-533. Elsevier.
- Reddy, D. S. (2017). Perimenstrual Seizures and Neurosteroid Withdrawal. Models of Seizures and Epilepsy. 933-940. Elsevier.
- Sohrabji, F., Welsh, C. J., & Reddy, D. S. (2016). Sex Differences in Neurological Diseases. Sex Differences in the Central Nervous System. 297-323. Elsevier.
- Reddy, D. S. (2013). Neurosteroid Influences on Neuronal Excitability. Epilepsy in Women. 23-40. JOhn Wiley & Sons.
Conference Papers12
- Wu, X., Muthuchamy, M., & Reddy, D. S. (2012). Atomic force microscopy study of ECM-integrin modulation of neuroplasticity in the hippocampal dentate granule cells in epilepsy. FASEB JOURNAL. 26,
- Carver, C., Wu, X., Murchison, D., Griffith, W., & Reddy, D. S. (2012). Ovarian cyclerelated effects of neurosteroids on GABAA receptormediated phasic and tonic currents in the hippocampus. The FASEB Journal. 26(S1), 1048.3-1048.3.
- Saraf, M., Briyal, S., & Reddy, D. S. (2009). ANTIEPILEPTOGENIC ACTIVITY OF PROGESTERONE IN WILD-TYPE AND PROGESTERONE RECEPTOR KNOCKOUT MICE. EPILEPSIA. 50, 126-126.
- Reddy, D. S. (2009). GENDER DIFFERENCES IN ANTISEIZURE SENSITIVITY OF NEUROSTEROIDS IN THE PILOCARPINE MODEL OF STATUS EPILEPTICUS. EPILEPSIA. 50, 126-126.
- Reddy, D. S., & Rogawski, M. A. (2009). Protective Efficacy and Potency of Neuroactive Steroids and Benzodiazepines in the Amygdala Kindling Model of Epilepsy. FASEB JOURNAL. 23,
- Texas A&M Neuroscientists Discover New Therapy For Refractory Epilepsy Texas A&M Today June 24, 2020
Patents2
- Reddy, D. S. (2019). Method of treating organophosphate intoxication by administration of neurosteroids.
- Reddy, D. S. (2019). Method of treating organophosphate intoxication by administration of neurosteroids.
Principal Investigator5
- Neurosteroid Therapy for Gulf War Illness awarded by U.S. Army Medical Research Acquisition Activity 2019 - 2021
- Epigenetic mechanisms of post-traumatic epilepsy awarded by DOD-Army-Medical Research and Materiel Command 2016 - 2020
- Editor of Epilepsy Currents conferred by American Epilepsy Society - (Chicago, Illinois, United States) - This is ongoing. 2014
- BICH491 Hnr-research Instructor
- BICH491 Research Instructor
- GENE491 Hnr-research Instructor
- GENE491 Research Instructor
- MEID608 Neuroscience Instructor
- Carver, Chase M (2015-05). Role of Delta Subunit-Containing GABAA Receptors in Hippocampus Tonic Inhibition and Epileptogenesis within Transgenic Mouse Models. (Doctoral Dissertation)