overview
The long-term goal of Dr. Wu's research program is to elucidate the mechanisms underlying the pathogenesis of obesity and overnutrition-associated metabolic diseases including insulin resistance, diabetes, and fatty liver disease so that novel dietary and/or pharmacological approaches can be developed for preventing and/or treating metabolic diseases. Using molecular, cellular, and integrative approaches, the Wu lab is focused on investigating the interaction between metabolism and inflammation.
education and training
- Ph.D. in Medical Science, Peking University - (Beijing, Beijing, China) 1998
- M.A.Sc. in Medical Science, Tongji Hospital - (Wuhan, China) 1992
selected publications
Academic Articles93
- Shi, G., Liu, D., Zhou, B., Liu, Y., Hao, B., Yu, S., ... Qian, X. (2020). Ginsenoside Rb1 Alleviates Oxidative Low-Density Lipoprotein-Induced Vascular Endothelium Senescence via the SIRT1/Beclin-1/Autophagy Axis.. Journal of Cardiovascular Pharmacology. 75(2), 155-167.
- Ma, L., Li, H., Hu, J., Zheng, J., Zhou, J., Botchlett, R., ... Wu, C. (2020). Indole Alleviates Diet‐Induced Hepatic Steatosis and Inflammation in a Manner Involving Myeloid Cell 6‐Phosphofructo‐2‐Kinase/Fructose‐2,6‐Biphosphatase 3. Hepatology (Baltimore, Md.).
- Kyritsi, K., Chen, L., O’Brien, A., Francis, H., Hein, T. W., Venter, J., ... Glaser, S. S. (2020). Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase‐A/5‐Hydroxytryptamine/5‐Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis. Hepatology (Baltimore, Md.). 71(3), 990-1008.
- Mingjuan Deng, .., Fang Qu, .., Long Chen, .., Chang Liu, .., Ming Zhang, .., Fazheng Ren, .., ... Liang Zhao, .. (2020). SCFAs alleviated steatosis and inflammation in mice with NASH induced by MCD. The Journal of endocrinology. -1(aop), 425-437.
- Wang, X., Rao, H., Zhao, J., Wee, A., Li, X., Fei, R., ... Wei, L. (2020). STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease. LABORATORY INVESTIGATION. 100(4), 542-552.
Chapters1
- Woo, S., Guo, T., & Wu, C. (2016). Hepatic Lipogenesis: Nutritional Control and Pathophysiological Relevance. Hepatic De Novo Lipogenesis and Regulation of Metabolism. (pp. 211-234). Springer International Publishing.
Conference Papers25
- Zhou, J., Li, H., Lu, B., Zhu, B., & Wu, C. (2019). DISRUPTION OF ADENOSINE 2A RECEPTOR EXACERBATES MCD-INDUCED NASH PHENOTYPE IN MICE. Hepatology (Baltimore, Md.). 70, 1313A-1314A.
- Zhou, T., Wu, C., Wu, N., Ceci, L. D., Mancinelli, R. A., Onori, P., ... Glaser, S. S. (2019). DOWNREGULATION OF STIMULATOR OF INTERFERON GENES (STING) DECREASES BILIARY SENESCENCE AND LIVER FIBROSIS IN CHOLESTATIC MICE THROUGH A DECREASE EXPRESSION OF tmiR24-3p/MELATONIN/AANAT/PER1 SIGNALING.. Hepatology (Baltimore, Md.). 70, 1112A-1113A.
- Wang, X., Rao, H., Zhao, J., Wee, A., Li, X., Fei, R., ... Wei, L. (2019). STING EXPRESSION IN MONOCYTE-DERIVED MACROPHAGES IS ASSOCIATED WITH THE PROGRESSION OF LIVER INFLAMMATION AND FIBROSIS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE. Hepatology (Baltimore, Md.). 70, 1279A-1279A.
- Zhou, T., Kyritsi, K., Wu, N., Francis, H., Yang, Z., Chen, L., ... Glaser, S. (2019). Knockdown of vimentin reduces mesenchymal phenotype of cholangiocytes in the Mdr2−/− mouse model of primary sclerosing cholangitis (PSC). EBioMedicine. 48, 130-142.
- Li, H., Ma, L., Zhou, J., Luo, X., Francis, H. L., Glaser, S., ... Wu, C. (2018). Disruption of Myeloid Cell-Specific PFKFB3 Exacerbates Diet-Induced Hepatic Steatosis and Inflammation in Mice. Hepatology (Baltimore, Md.). 68, 732A-732A.
teaching activities
- NFSC475 Nutr & Physiolog Chem Instructor
- NFSC485 Directed Studies Instructor
- NFSC491 Hnr-research Instructor
- NFSC491 Research Instructor
- NFSC642 Nutritional Bich Ii Instructor
chaired theses and dissertations
- Woo, Shih Lung (2016-12). Beneficial Effects of Metformin in Diet-Induced Obesity Associated Non-Alcoholic Fatty Liver Disease. (Doctoral Dissertation)
- Botchlett, Rachel Erin (2015-12). Nutrient Regulation of PFKFB3/iPFK2 and Its Role in Regulating Diet-Induced Inflammation in Intestinal Epithelial Cells. (Doctoral Dissertation)
- Qi, Ting (2015-08). Involvement of PFKFB3/iPFK2 in Beneficial Effects of Metformin on 3T3-L1 Adipocytes and Temporal Effects of Pioglitazone on Adipocytes. (Master's Thesis)
- Guo, Ting (2015-05). Beneficial Effects of Berberine on Nonalcoholic Fatty Liver Disease (NAFLD). (Master's Thesis)
- Guo, Xin (2013-05). A Role for PFKFB3/IPFK2 in Overnutrition-Associated Adipose Tissue and Intestine Inflammatory Responses and Insulin Resistance. (Doctoral Dissertation)
Email
cdwu@tamu.edu
First Name
Chaodong
Last Name
Wu
mailing address
Texas A&M University; Nutrition; 2253 TAMU
College Station, TX 77843-2253
USA