overview
The long-term goal of Dr. Wu's research program is to elucidate the mechanisms underlying the pathogenesis of obesity and overnutrition-associated metabolic diseases including insulin resistance, diabetes, and fatty liver disease so that novel dietary and/or pharmacological approaches can be developed for preventing and/or treating metabolic diseases. Using molecular, cellular, and integrative approaches, the Wu lab is focused on investigating the interaction between metabolism and inflammation.
education and training
- Ph.D. in Medical Science, Peking University - (Beijing, Beijing, China) 1998
- M.A.Sc. in Medical Science, Tongji Hospital - (Wuhan, China) 1992
selected publications
Academic Articles107
- Zhu, B., Guo, X., Xu, H., Jiang, B., Li, H., Wang, Y., ... Wu, C. (2021). Adipose tissue inflammation and systemic insulin resistance in mice with diet-induced obesity is possibly associated with disruption of PFKFB3 in hematopoietic cells. LABORATORY INVESTIGATION. 101(3), 328-340.
- Wu, N., Baiocchi, L., Zhou, T., Kennedy, L., Ceci, L., Meng, F., ... Alpini, G. (2020). Functional Role of the Secretin/Secretin Receptor Signaling During Cholestatic Liver Injury. Hepatology. 72(6), 2219-2227.
- Zhang, J., Zhu, S., Ma, N., Johnston, L. J., Wu, C., & Ma, X. i. (2020). Metabolites of microbiota response to tryptophan and intestinal mucosal immunity: A therapeutic target to control intestinal inflammation. Medicinal Research Reviews. 41(2), 1061-1088.
- Jiang, X., Zheng, J., Zhang, S., Wang, B., Wu, C., & Guo, X. (2020). Advances in the Involvement of Gut Microbiota in Pathophysiology of NAFLD. Frontiers in Medicine. 7, 361.
- Ceci, L., Francis, H., Zhou, T., Giang, T., Yang, Z., Meng, F., ... Alpini, G. (2020). Knockout of the Tachykinin Receptor 1 in the Mdr2−/− (Abcb4 −/−) Mouse Model of Primary Sclerosing Cholangitis Reduces Biliary Damage and Liver Fibrosis. American Journal Of Pathology. 190(11), 2251-2266.
Chapters1
- Woo, S., Guo, T., & Wu, C. (2016). Hepatic Lipogenesis: Nutritional Control and Pathophysiological Relevance. Hepatic De Novo Lipogenesis and Regulation of Metabolism. (pp. 211-234). Springer International Publishing.
Conference Papers27
- Chen, L., Wu, N., Yang, Z., Francis, H. L., Ceci, L., Zhou, T., ... Alpini, G. (2020). THE BILIARY SECRETIN/SECRETIN RECEPTOR (SCT/SR)/MIR-125b AXIS REGULATES HEPATIC STEATOSIS AND LIVER ANGIOGENESIS IN NONALCOHOLIC FATTY LIVER DISEASE (NAFLD). Hepatology. 72, 350A-350A.
- Zhou, T., O'Brien, A., White, T., Wu, N., Kennedy, L., Francis, H. L., ... Glaser, S. S. (2020). mtDNA RELEASED BY CHOLANGIOCYTES PROMOTES STING ACTIVATION AND FIBROTIC REACTION. Hepatology. 72, 251A-252A.
- Zhou, J., Li, H., Lu, B., Zhu, B., & Wu, C. (2019). DISRUPTION OF ADENOSINE 2A RECEPTOR EXACERBATES MCD-INDUCED NASH PHENOTYPE IN MICE. Hepatology. 70, 1313A-1314A.
- Zhou, T., Wu, C., Wu, N., Ceci, L. D., Mancinelli, R. A., Onori, P., ... Glaser, S. S. (2019). DOWNREGULATION OF STIMULATOR OF INTERFERON GENES (STING) DECREASES BILIARY SENESCENCE AND LIVER FIBROSIS IN CHOLESTATIC MICE THROUGH A DECREASE EXPRESSION OF tmiR24-3p/MELATONIN/AANAT/PER1 SIGNALING.. Hepatology. 70, 1112A-1113A.
- Wang, X., Rao, H., Zhao, J., Wee, A., Li, X., Fei, R., ... Wei, L. (2019). STING EXPRESSION IN MONOCYTE-DERIVED MACROPHAGES IS ASSOCIATED WITH THE PROGRESSION OF LIVER INFLAMMATION AND FIBROSIS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE. Hepatology. 70, 1279A-1279A.
in the news
researcher on
Principal Investigator5
- Protective role of adenosine 2A receptor in NAFLD awarded by National Institutes of Health 2013 - 2019
- Metabolic regulation of adipocyte-macrophage crosstalk in obesity awarded by National Institutes of Health 2013 - 2018
Co-Principal Investigator1
awards and honors
recent teaching activities
- NFSC475 Nutr & Physiolog Chem Instructor
- NFSC485 Directed Studies Instructor
- NFSC491 Research Instructor
- NFSC642 Nutritional Bich Ii Instructor
- NFSC681 Seminar Instructor
chaired theses and dissertations
- Woo, Shih Lung (2016-12). Beneficial Effects of Metformin in Diet-Induced Obesity Associated Non-Alcoholic Fatty Liver Disease. (Doctoral Dissertation)
- Botchlett, Rachel Erin (2015-12). Nutrient Regulation of PFKFB3/iPFK2 and Its Role in Regulating Diet-Induced Inflammation in Intestinal Epithelial Cells. (Doctoral Dissertation)
- Qi, Ting (2015-08). Involvement of PFKFB3/iPFK2 in Beneficial Effects of Metformin on 3T3-L1 Adipocytes and Temporal Effects of Pioglitazone on Adipocytes. (Master's Thesis)
- Guo, Ting (2015-05). Beneficial Effects of Berberine on Nonalcoholic Fatty Liver Disease (NAFLD). (Master's Thesis)
- Guo, Xin (2013-05). A Role for PFKFB3/IPFK2 in Overnutrition-Associated Adipose Tissue and Intestine Inflammatory Responses and Insulin Resistance. (Doctoral Dissertation)
Email
cdwu@tamu.edu
First Name
Chaodong
Last Name
Wu
mailing address
Texas A&M University; Nutrition; 2253 TAMU
College Station, TX 77843-2253
USA