- Assistant Professor, Biology, College of Science
We are at the beginning of an exciting new era for neuroscience, as our ability to probe neural circuits and their neuronal components is advancing rapidly due to genetic and optogenetic tools. Our research program applies these tools to address fundamental questions about how the same neural circuitry generates different motor patterns, and how such circuits develop and are maintained. We investigate these questions using the Drosophila larva, which has the following advantages:(i) The connectome of the larval motor circuit is near completion, enabling us to identify, at the single-synapse level, the pre and postsynaptic partners of each individual neuron embedded in it. This anatomical map has provided an excellent substrate to study the development, maintenance, and function of larval motor circuits as well as the cell biology of individual neurons embedded within it. (ii) The larval CNS generates multiple motor behaviors that can be studied at the single neuron/single muscle level. Moreover, using the modern optogenetic methods, it is possible to access individual neurons, monitor or alter their activity, and observe the behavioral consequences. (iii) It is also feasible to selectively inactivate or induce ectopic expression of any gene (e.g. those coding for transcription factors) in the neuron of interest, and examine its effect on intrinsic neural properties, morphology, connectivity pattern, and behavioral performance of the animal, thereby linking the gene to development and behavior.
- Howard Hughes Medical Institute - (Chevy Chase, Maryland, United States), Postdoctoral Training
- Ph.D. in Neuroscience/Genetics, Trinity College Dublin - (Dublin, Dublin, Ireland) 2013
Academic Articles13
- Mark, B., Lai, S., Zarin, A. A., Manning, L., Pollington, H. Q., Litwin-Kumar, A., ... Doe, C. Q (2021). A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS.. Elife. 10, e67510.
- Zarin, A. A., Mark, B., Cardona, A., Litwin-Kumar, A., & Doe, C. Q (2019). A multilayer circuit architecture for the generation of distinct locomotor behaviors in Drosophila.. Elife. 8, e51781.
- Mark, B., Lai, S., Zarin, A. A., Manning, L., Litwin-Kumar, A., Cardona, A., Truman, J. W., & Doe, C. Q (2019). A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS. 617936.
- Zarin, A. A., Mark, B., Cardona, A., Litwin-Kumar, A., & Doe, C. Q (2019). ADrosophilalarval premotor/motor neuron connectome generating two behaviors via distinct spatio-temporal muscle activity. 617977.
- Arzan Zarin, A., & Labrador, J (2019). Motor axon guidance in Drosophila.. Semin Cell Dev Biol. 85, 36-47.
- BIOL213 Hnr-molecular Cell Biol Instructor
- BIOL213 Molecular Cell Biol Instructor
- BIOL291 Research Instructor
- BIOL491 Hnr-research Instructor
- BIOL491 Research Instructor