Mccreedy, Dylan individual record
Assistant Professor

My lab investigates the roles of early inflammation in tissue damage and wound healing following spinal cord injury. We employ genetic and pharmacological methods to study how immune receptors (e.g. L-selectin) and signaling pathways alter the accumulation and activation of early arriving immune cells, predominantly neutrophils. We are also developing new three-dimensional imaging strategies to characterize inflammation and tissue damage after spinal cord injury. Utilizing tissue clearing techniques and lightsheet microscopy, we can visualize the spatiotemporal effects of spinal cord injury in a manner previously unachievable with traditional imaging modalities. With the knowledge gained from these studies, we aim to develop novel neuroprotective strategies to reduce inflammatory damage and improve long-term recovery for the spinal cord injured patient.

education and training
selected publications
Academic Articles18
  • Van Sandt, R. L., Welsh, C. J., Jeffery, N. D., Young, C. R., McCreedy, D. A., Wright, G. A., ... Levine, J. M (2022). Circulating neutrophil activation in dogs with naturally occurring spinal cord injury secondary to intervertebral disk herniation. American Journal of Veterinary Research. 1-7.
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  • McCreedy, D. A., Abram, C. L., Hu, Y., Min, S. W., Platt, M. E., Kirchhoff, M. A., ... Lowell, C. A (2021). Spleen tyrosine kinase facilitates neutrophil activation and worsens long-term neurologic deficits after spinal cord injury. Journal of Neuroinflammation. 18(1), 302.
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  • Gibbs, H. C., Mota, S. M., Hart, N. A., Min, S. W., Vernino, A. O., Pritchard, A. L., ... Perez, L. M. (2021). Navigating the Light-Sheet Image Analysis Software Landscape: Concepts for Driving Cohesion From Data Acquisition to Analysis. Frontiers in Cell and Developmental Biology. 9, 739079.
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  • McCreedy, D. A., Jalufka, F. L., Platt, M. E., Min, S. W., Kirchhoff, M. A., Pritchard, A. L., ... McDevitt, T. C (2021). Passive Clearing and 3D Lightsheet Imaging of the Intact and Injured Spinal Cord in Mice. Frontiers in Cellular Neuroscience. 15, 684792.
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  • Massopust, R. T., Lee, Y. I., Pritchard, A. L., Nguyen, V., McCreedy, D. A., & Thompson, W. J (2020). Lifetime analysis of mdx skeletal muscle reveals a progressive pathology that leads to myofiber loss.. Sci Rep. 10(1), 17248.
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Repository Documents / Preprints1
  • McCreedy, D. A., Jalufka, F. L., Platt, M. E., Min, S. W., Kirchhoff, M. A., Manlapaz, R., ... McDevitt, T. C (2021). Passive clearing and 3D lightsheet imaging of the intact and injured spinal cord in mice.
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