The development, control and diseases of the musculoskeletal system have been my scholarly interests for the past 30+ years. Understanding how the musculoskeletal system adapts and progresses throughout life is the basis of my expertise. My research focus has been the skeletal consequences of disease, such as breast cancer bone metastasis and multiple myeloma, osteosarcoma chemotherapy, fracture healing, osteoporosis, diabetes and bone infections. Current research efforts include a focus on in vivo models (murine and larger animals) to discover regulatory pathways fundamental to bone physiology and the development of rare bone disease pre-clinical model(s) that may provide novel insight into future therapeutic directions. A critical aspect of my academic philosophy is an open door policy and the importance of one-on-one interactions. We must strive to provide training and exposure for our students as they prepare for careers both in and out of academic medicine and research. I emphatically believe that these teaching and mentoring experiences have shaped my scientific career and have helped mold my teaching and mentoring philosophy of placing the best professional, academic, social and personal development of faculty, students and staff above all else.
- Suva, L. J., Westhusin, M. E., Gaddy, D., & Long, C. R. (2020). Engineering bone phenotypes in domestic animals: Unique resources for enhancing musculoskeletal research. BONE. 130, 115119-115119.
- Robinson, J. W., Blixt, N. C., Norton, A., Mansky, K. C., Ye, Z., Aparicio, C., ... Potter, L. R. (2020). Male mice with elevated C-type natriuretic peptide-dependent guanylyl cyclase-B activity have increased osteoblasts, bone mass and bone strength. BONE. 135, 115320-115320.
- Khalaf, O. H., Chaki, S. P., Garcia-Gonzalez, D. G., Suva, L. J., Gaddy, D., & Arenas-Gamboa, A. M. (2020). Interaction of Brucella abortus with Osteoclasts: a Step toward Understanding Osteoarticular Brucellosis and Vaccine Safety.. INFECTION AND IMMUNITY. 88(4),
- Williams, D. K., Pinzon, C., Huggins, S., Pryor, J. H., Falck, A., Herman, F., ... Gaddy, D. (2018). Genetic engineering a large animal model of human hypophosphatasia in sheep. SCIENTIFIC REPORTS. 8(1), 16945.
- Kamalakar, A., Washam, C. L., Akel, N. S., Allen, B. J., Williams, D. K., Swain, F. L., ... Suva, L. J. (2017). PTHrP(12‐48) Modulates the Bone Marrow Microenvironment and Suppresses Human Osteoclast Differentiation and Lifespan. Journal of Bone and Mineral Research. 32(7), 1421-1431.
- Chorev, M., Behar, V., Nakamoto, C., Adams, A. E., Stueckle, S. M., Suva, L. J., & Rosenblatt, M. (1995). Benzophenone-modified parathyroid hormone (PTH) analogs as novel tools for ‘photoaffinity scanning’ of ligand-receptor interactions. Peptides 1994. (pp. 125-126). Springer Netherlands.
- MOSELEY, J. M., & SUVA, L. J. (1990). Isolation, biochemistry and molecular biology of the PTH-related protein of malignant hypercalcemia. Bone and Mineral Research. (pp. 175-208). Elsevier.
- Williams, D. K., Pinzon, C. A., Huggins, S., Pryor, J. H., Georges, H. M., Hermann, F., ... Suva, L. J. (2018). Genetically Engineering a Sheep Model of Hypophosphatasia. The FASEB Journal. 32(1),
- Williams, D. K., Pryor, J. H., Huggins, S., Georges, H. M., Pinzon, C. A., Hermann, F., ... Suva, L. J. (2017). Genetic engineering a sheep model of Hypophosphatasia.. Journal of Bone and Mineral Research. 32, S397-S397.
- Nicks, K. M., Fowler, T. W., Akel, N. S., Perrien, D. S., Suva, L. J., & Gaddy, D. (2010). Bone turnover across the menopause transition. TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY. 1192(1), 153-160.
- Bendre, M., Gaddy, D., Nicholas, R. W., & Suva, L. J. (2003). Breast Cancer Metastasis to Bone. Clinical Orthopaedics and Related Research. 415(&NA;), s39-s45.
- Skerry, T. M., Genever, P. G., Patton, A. J., Grabowski, P. S., Stueckle, S., & Suva, L. J. (1996). Glutamate receptors in bone cells suggest a paracrine role for excitatory amino acids in regulation of the skeleton?. Journal of Bone and Mineral Research. 11, P202-P202.