Groppe, Jay individual record
Associate Professor
selected publications
Academic Articles19
  • Kaplan, F. S., Groppe, J. C., Xu, M., Towler, O. W., Grunvald, E., Kalunian, K., ... Shore, E. M (2022). An ACVR1 R375P pathogenic variant in two families with mild fibrodysplasia ossificans progressiva. American Journal of Medical Genetics Part A. 188(3), 806-817.
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  • Groppe, J. C (2019). Induced degradation of protein kinases by bifunctional small molecules: a next-generation strategy.. Expert Opin Drug Discov. 14(12), 1237-1253.
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  • Lu, G., Tandang-Silvas, M. R., Dawson, A. C., Dawson, T. J., & Groppe, J. C (2018). Hypoxia-selective allosteric destabilization of activin receptor-like kinases: A potential therapeutic avenue for prophylaxis of heterotopic ossification.. Bone. 112, 71-89.
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  • Whitman, M., Rosen, V., Brivanlou, A. H., Groppe, J. C., Sebald, W., & Mueller, T (2013). Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3.. Nat Med. 19(7), 809-810.
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  • Ishii, Y., Takizawa, T., Iwasaki, H., Fujita, Y., Murakami, M., Groppe, J. C., & Tanaka, K (2012). Nucleotide polymorphisms in the canine Noggin gene and their distribution among dog (Canis lupus familiaris) breeds.. Biochem Genet. 50(1-2), 12-18.
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  • Kaplan, F. S., Groppe, J. C., Seemann, P., Pignolo, R. J., & Shore, E. M. (2010). Fibrodysplasia Ossificans Progressiva: Developmental Implications of a Novel Metamorphogene. Bone and Development. 233-249. Springer London.
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Conference Papers5
  • Groppe, J. C., Lu, G., TandangSilvas, M. R., Dawson, A., & Dawson, T. (2018). Hypoxiaselective allosteric destabilization and degradation of a receptor protein kinase: potential prophylaxis by HSAAD/Ds. The FASEB Journal. 32(S1), 799.8-799.8.
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  • Groppe, J. C., Tandang-Silvas, M. R., Pathi, A., Wu, J., Lu, G., Le, V. Q., ... Kaplan, F. S (2016). Activities of Dysregulated ALK2 Receptor Kinases Provide Insight Into the Protein Structural-Functional Basis of Fibrodysplasia Ossificans Progressiva. FASEB JOURNAL. 30,
  • Groppe, J. C., Lu, G., Dawson, A., & Dawson, T (2016). Novel Allosteric Destabilizers as Therapeutics for Genetic Diseases and Trauma. FASEB JOURNAL. 30,
  • Groppe, J. C., Wu, J., Shore, E. M., & Kaplan, F. S (2011). In vitro analyses of the dysregulated R206H ALK2 kinase-FKBP12 interaction associated with heterotopic ossification in FOP.. Cells Tissues Organs. 194(2-4), 291-295.
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  • Groppe, J. C., Greenwald, J., Wiater, E., Rodriguez-Leon, J., Economides, A. N., Kwiatkowski, W., ... Choe, S (2002). Structural basis of BMP signalling inhibition by Noggin, a novel cystine knot protein. MOLECULAR BIOLOGY OF THE CELL. 13, 6A-6A.
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Texas A&M University College of Dentistry; Biomedical Sciences; 3302 Gaston Avenue
Dallas, TX 75246