overview

Our laboratory uses the mouse as an experimental genetic model to investigate factors that contribute to inter-individual differences in health and disease. Ourcurrent research activities include the identification and functional characterization of alleles contributing to cancer susceptibility, the function of theErbbgenefamily in development and disease, and the role of genetic variation in response to environmental stimuli. To support these investigations, we also aredeveloping new genetic tools to support mammalian systems genetic approaches to phenotypes with complex genetic and environmental etiologies.

selected publications
Academic Articles314
  • Lees‐Shepard, J. B., Flint, K., Fisher, M., Omi, M., Richard, K., Antony, M., ... Dealy, C. N. (2022). Cross‐talk between EGFR and BMP signals regulates chondrocyte maturation during endochondral ossification. Developmental Dynamics. 251(1), 193-212.
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  • Perez Gomez, A. A., Karmakar, M., Carroll, R. J., Lawley, K. S., Amstalden, K., Young, C. R., ... Brinkmeyer-Langford, C. (2021). Genetic and immunological contributors to virus-induced paralysis. Brain, Behavior, & Immunity - Health. 18, 100395-100395.
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  • Mantilla Rojas, C., McGill, M. P., Salvador, A. C., Bautz, D., & Threadgill, D. W. (2021). Epithelial-specific ERBB3 deletion results in a genetic background-dependent increase in intestinal and colon polyps that is mediated by EGFR. PLOS Genetics. 17(11), e1009931-e1009931.
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  • Brinkmeyer-Langford, C., Amstalden, K., Konganti, K., Hillhouse, A., Lawley, K., Perez-Gomez, A., ... Threadgill, D. W. (2021). Resilience in Long-Term Viral Infection: Genetic Determinants and Interactions. International Journal of Molecular Sciences. 22(21), 11379-11379.
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  • Elias, L., Blazier, J. C., Rogovska, Y. V., Konganti, K., Wang, J., Liu, S., ... Rogovskyy, A. S. (2021). Extensive sex-specific and regional variations observed in the microbiome of Dermacentor reticulatus.. Ticks Tick Borne Dis. 12(5), 101767-101767.
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Chapters4
  • Wang, W., McMillan, L., "Threadgill,", D., & Pardo-Manuel de Villena, F. (2008). Efficient Data-Mining Methods Enabling Genome-Wide Computing. Chapman & Hall/CRC Data Mining and Knowledge Discovery Series. 49-67. Chapman and Hall/CRC.
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  • Roberts, R. B., & Threadgill, D. W. (2005). THE MOUSE IN BIOMEDICAL RESEARCH. Eisen, E. J. (Eds.), The Mouse in Animal Genetics and Breeding Research. 319-340. PUBLISHED BY IMPERIAL COLLEGE PRESS AND DISTRIBUTED BY WORLD SCIENTIFIC PUBLISHING CO..
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  • Threadgill, D. W., Hunter, K. W., Zou, F., & Manly, K. F. (2004). Genetic Modifiers. Mouse Models of Human Cancer. John Wiley & Sons, Inc..
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  • Threadgill, D. W., Yee, D., Thompson, C., & Magnuson, T. (1995). Epidermal Growth Factor Receptor Deficiency Results in Periimplantation Lethality in Mouse. Molecular and Cellular Aspects of Periimplantation Processes. 231-235. Springer New York.
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Conference Papers51
  • Bokhari, R., Schneider, P., Barrington, W., Falck, A., Mitchell, A., Huggins, S., ... Gaddy, D. (2018). Sex and Diet Specific Differences In Bone Mass of 4 Mouse Strains: Can Mice Tell Us What to Eat for Bone Health?. JOURNAL OF BONE AND MINERAL RESEARCH. 33, 413-413.
  • Lanier, A., Barrington, W., & Threadgill, D. (2017). Abstract 1542: Identifying genetic modifiers of PTEN using the Collaborative Cross mouse panel. Cancer Research. 77(13_Supplement), 1542-1542.
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  • Rojas, C. M., Ming, Y. u., & Threadgill, D. (2017). Abstract 3400: Progression of epidermal growth factor receptor (EGFR)-independent colorectal cancer. Cancer Research. 77(13_Supplement), 3400-3400.
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  • Rojas, C. M., & Threadgill, D. (2017). Abstract A15: Progression of colorectal cancer through epidermal growth factor receptor (EGFR)-independent mechanisms. Cancer Research. 77(3_Supplement), A15-A15.
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  • Cichocki, J. A., Furuya, S., Luo, Y. S., Sweet, S., Wade, T., Knap, A., ... Rusyn, I. (2016). Xenobiotic metabolism in a mouse model of non-alcoholic fatty liver disease: A case study of the ubiquitous environmental contaminant tetrachloroethylene. HEPATOLOGY. 64, 800A-800A.
Repository Documents / Preprints5
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  • Sigmon, J. S., Blanchard, M. W., Baric, R. S., Bell, T. A., Brennan, J., Brockmann, G. A., ... de Villena, F. (2020). Content and performance of the MiniMUGA genotyping array, a new tool to improve rigor and reproducibility in mouse research.
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  • Sudweeks, J., Hollingsworth, B., Blondel, D. V., Campbell, K. J., Dhole, S., Eisemann, J. D., ... Lloyd, A. L. (2019). Locally Fixed Alleles: A method to localize gene drive to island populations.
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  • Price, A., Okumura, A., Haddock, E., Feldmann, F., Meade-White, K., Sharma, P., ... Rasmussen, A. L. (2019). Transcriptional Correlates of Tolerance and Lethality in Mice Predict Ebola Virus Disease Patient Outcomes.
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  • Didion, J. P., Morgan, A. P., Yadgary, L., Bell, T. A., McMullan, R. C., Ortiz de Solorzano, L., ... Pardo-Manuel de Villena, F. (2015). R2d2 drives selfish sweeps in the house mouse.
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researcher on
chaired theses and dissertations
Email
dwthreadgill@tamu.edu
First Name
David
Last Name
Threadgill
mailing address
Texas A&M University; Vet Med Pathobiology; 4467 TAMU
College Station, TX 77843-4467
USA