overview

The promise for the treatment of proliferative disorders, with incalculable potential benefits to human health, has driven basic research into the genetic control of cell division for decades. However, what determines when cells initiate their division remains mysterious. It is as if we are staring at a beautiful engine, with little knowledge about what turns it on. How cells are set off to a new round of cell division, remains as one of the most fundamental, unanswered questions. It is virtually unknown which cellular pathways affect initiation of division, which factors operate within each pathway, the extent of interactions between pathways, and how each pathway is molecularly linked to the machinery of cell division. Our studies aim to answer these questions using baker's yeast. This model organism has a machinery of cell division that is very similar to that of human cells, and it is suited for genetic and biochemical studies.

education and training
selected publications
Academic Articles50
  • Maitra, N., Hammer, S., Kjerfve, C., Bankaitis, V. A., & Polymenis, M. (2022). Translational control of lipogenesis links protein synthesis and phosphoinositide signaling with nuclear division in Saccharomyces cerevisiae. Genetics. 220(1),
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  • Maitra, N., Hammer, S., Kjerfve, C., Bankaitis, V. A., & Polymenis, M. (2021). Translational control of lipogenesis links protein synthesis and phosphoinositide signaling with nuclear division. 2021.01.03.425130.
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  • Zou, K. e., Rouskin, S., Dervishi, K., McCormick, M. A., Sasikumar, A., Deng, C., ... Li, H. (2020). Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span.. Sci Adv. 6(32), eaba1306.
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Chapters1
  • Polymenis, M., & Kennedy, B. K. (2017). Unbalanced Growth, Senescence and Aging.. MATHEMATICAL MODELLING IN EXPERIMENTAL NUTRITION. Advances in Experimental Medicine and Biology. 189-208. Springer International Publishing.
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Conference Papers1
  • Wu, J., Polymenis, M., & Han, A. (2011). A low dilution rate microchemostat array with programmable cell population control. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. 1, 88-90.
Repository Documents / Preprints1
  • Polymenis, M., & Aramayo, R. (2015). Translate to divide: ontrol of the cell cycle by protein synthesis.. Microbial Cell.
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chaired theses and dissertations
Email
polymenis@tamu.edu
First Name
Michael
Last Name
Polymenis
mailing address
Texas A&M University; Biochemistry & Biophysics; 2128 TAMU
College Station, TX 77843-2128
USA