Peterson, David individual record
Professor and Associate Department Head
Positions:
overview

We are interested in the molecular mechanisms of transcriptional regulation in mammalian cells. Many of our experiments have focused on the transcription of the proviral genome of the retrovirus mouse mammary tumor virus, which is subject to both positive and negative control. A number of cellular proteins that are important for viral transcription have been identified, and we would like to define the precise roles of these proteins in establishing correct levels of viral gene expression. We are also exploring some specific questions related to the general mechanism of transcription initiation by RNA polymerase II and the biochemical details of transcriptional regulation. In particular, we are developing assays to directly assess effects of transcriptional regulatory proteins on discrete steps in the initiation process, including transcription complex assembly, separation of the two strands of template DNA at the initiation site, and promoter clearance by the polymerase as it begins RNA synthesis.

selected publications
Academic Articles25
  • Kaster, B. C., Knippa, K. C., Kaplan, C. D., & Peterson, D. O. (2016). RNA Polymerase II Trigger Loop Mobility: INDIRECT EFFECTS OF Rpb9.. J Biol Chem. (28), 14883-14895.
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  • Nesser, N. K., Peterson, D. O., & Hawley, D. K. (2006). RNA polymerase II subunit Rpb9 is important for transcriptional fidelity in vivo. 103(9), 3268-3273.
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  • Chen, X., Zhang, B. o., Harmon, P. M., Schaffner, W., Peterson, D. O., & Giedroc, D. P. (2003). A Novel Cysteine Cluster in Human Metal-responsive Transcription Factor 1 Is Required for Heavy Metal-induced Transcriptional Activation in Vivo *. 279(6), 4515-4522.
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Conference Papers4
  • KANG, C. J., FEE, B. E., BRAL, C. M., & PETERSON, D. O. (1994). IN-VITRO ANALYSIS OF MOUSE MAMMARY-TUMOR VIRUS TRANSCRIPTION. 47-47.
  • PETERSON, D. O., PIERCE, J., MOFFITT, P. G., & LEE, J. W. (1992). TRANSCRIPTIONAL REGULATION OF MOUSE MAMMARY-TUMOR VIRUS GENE-EXPRESSION. 6(1), A72-A72.
  • PETERSON, D. O., TOOHEY, M. G., & MORLEY, K. L. (1986). MULTIPLE TRANSCRIPTIONAL REGULATORY ELEMENTS AS MEDIATORS OF DIFFERENTIAL TRANSCRIPTION. 189-189.
chaired theses and dissertations
Email
dopeterson@tamu.edu
First Name
David
Last Name
Peterson
mailing address
Texas A&M University; Biochemistry & Biophysics; 2128 TAMU
College Station, TX 77843-2128
USA