Dashwood, PhD, FRSB, Roderick individual record
Professor and Director

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overview

The current focus is on integrating genetic/epigenetic/immune mechanisms in colorectal cancer etiology. The genetic basis of oncology is studied using cultured human cancer cells and preclinical approaches, including the Apc-mutant polyposis in rat colon (Pirc) model coupled to a novel murine polypectomy methodology. Epigenomic aspects are studied through alterations in epigenetic 'readers', 'writers' and 'erasers', via combined deacetylase plus bromodomain inhibition, which also modulates immune-related players in cancer cells. Deacetylase/bromodomain expression and protein acetylation changes also are examined in clinical specimens, organoids, 3D spheroids, and human volunteers undergoing colonoscopy, thereby providing clinical translation of the research.

education and training
selected publications
Academic Articles218
  • Chen, Y., Li, J., Neja, S., Kapoor, S., Tovar Perez, J. E., Tripathi, C., ... Dashwood, R. (2022). Metabolomics of Acute vs. Chronic Spinach Intake in an Apc-Mutant Genetic Background: Linoleate and Butanoate Metabolites Targeting HDAC Activity and IFN- Signaling.. Cells. (3), 573-573.
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  • Kapoor, S., Gustafson, T., Zhang, M., Chen, Y., Li, J., Nguyen, N., ... Dashwood, R. H. (2021). Deacetylase Plus Bromodomain Inhibition Downregulates ERCC2 and Suppresses the Growth of Metastatic Colon Cancer Cells.. Cancers (Basel). 13(6), 1438-1438.
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  • Miller, M. S., Allen, P. J., Brown, P. H., Chan, A. T., Clapper, M. L., Dashwood, R. H., ... Mohammed, A. (2021). Meeting Report: Translational Advances in Cancer Prevention Agent Development Meeting.. J Cancer Prev. 26(1), 71-82.
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  • Ulusan, A. M., Rajendran, P., Dashwood, W. M., Yavuz, O. F., Kapoor, S., Gustafson, T. A., ... Dashwood, R. H. (2021). Optimization of Erlotinib Plus Sulindac Dosing Regimens for Intestinal Cancer Prevention in an Apc-Mutant Model of Familial Adenomatous Polyposis (FAP).. Cancer Prev Res (Phila). 14(3), 325-336.
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Chapters2
  • Beaver, L. M., Williams, D. E., Dashwood, R. H., & Ho, E. (2012). Chemoprevention of Prostate Cancer with Cruciferous Vegetables: Role of Epigenetics. Nutrition, Diet and Cancer. 49-81. Springer Netherlands.
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  • Delage, B., & Dashwood, R. (2008). Targeting the Epigenome with Dietary Agents. Oxidative Stress and Disease. 337-369. CRC Press.
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Conference Papers38
  • Rajendran, P., Ulusan, A., Dashwood, W., Kapoor, S., Mohammed, A., Sei, S., ... Dashwood, R. H. (2020). Abstract 21: Optimization of dosing regimens of sulindac in combination with erlotinib for small intestine and colorectal cancer prevention. Cancer Research. 80(16_Supplement), 21-21.
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  • Rajendran, P., Damiani, E., Wang, S., Dashwood, W., & Dashwood, R. H. (2020). Abstract 3477: Dietary polyphenols as epigenetic reader' inhibitors. Cancer Research. 80(16_Supplement), 3477-3477.
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  • Ulusan, A., Rajendran, P., Dashwood, W., Mohammed, A., Sei, S., Brown, P. H., Vilar-Sanchez, E., & Dashwood, R. H. (2019). Abstract 5074: Optimizing erlotinib plus sulindac dosing regimens in a preclinical model of FAP. Cancer Research. 79(13_Supplement), 5074-5074.
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  • Li, Q., Zhong, X. S., Nyeem, S. Z., Kline, K. T., Peng, J., Fujise, K., & Dashwood, R. H. (2018). Experimental colitis impedes cardiac function through epigenetic mechanisms. EUROPEAN HEART JOURNAL. 39, 994-995.
  • Orner, G., Dashwood, W. M., Tebbutt, N. C., Li, Q., Heath, J. K., Myzak, M. C., Ernst, M., & Dashwood, R. H. (2017). Cancer chemoprevention by a combination of white tea plus sulindac in a mouse model expressing an oncogenic form of beta-catenin.. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 12(11), 1287S-1287S.
Repository Documents / Preprints1
  • Chen, Y., Li, J., Menon, R., Jayaraman, A., Lee, K., Huang, Y., ... Dashwood, R. (2021). Reshaping the Gut Microbiome in An Apc-Mutant Genetic Background: Mechanistic Insights From Integrated Multi-Omics.
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recent teaching activities
chaired theses and dissertations
Email
rdashwood@tamu.edu
First Name
Roderick
Last Name
Dashwood, PhD, FRSB
mailing address
Texas A&M Health and College of Medicine; Center for Epigenetics & Disease Prevention; 1201 TAMUS
Houston, TX 77030-3303
USA

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