Dashwood, PhD, FRSB, Roderick individual record
Professor and Director
overview

The current focus is on integrating genetic/epigenetic/immune mechanisms in colorectal cancer etiology. The genetic basis of oncology is studied using cultured human cancer cells and preclinical approaches, including the Apc-mutant polyposis in rat colon (Pirc) model coupled to a novel murine polypectomy methodology. Epigenomic aspects are studied through alterations in epigenetic 'readers', 'writers' and 'erasers', via combined deacetylase plus bromodomain inhibition, which also modulates immune-related players in cancer cells. Deacetylase/bromodomain expression and protein acetylation changes also are examined in clinical specimens, organoids, 3D spheroids, and human volunteers undergoing colonoscopy, thereby providing clinical translation of the research.

education and training
selected publications
Academic Articles215
Chapters2
  • Beaver, L. M., Williams, D. E., Dashwood, R. H., & Ho, E. (2012). Chemoprevention of Prostate Cancer with Cruciferous Vegetables: Role of Epigenetics. Nutrition, Diet and Cancer. (pp. 49-81). Springer Netherlands.
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  • Delage, B., & Dashwood, R. H. (2008). Targeting the epigenome with dietary agents. Dietary Modulation of Cell Signaling Pathways. (pp. 337-369).
Conference Papers36
recent teaching activities
chaired theses and dissertations
Email
rdashwood@tamu.edu
First Name
Roderick
Last Name
Dashwood, PhD, FRSB
mailing address
Texas A&M Health and College of Medicine; Center for Epigenetics & Disease Prevention; 1201 TAMUS
Houston, TX 77030-3303
USA