Dashwood, Roderick individual record
Professor and Director

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overview

The current focus is on genetic and epigenetic mechanisms in cancer development. The genetic basis of cancer is studied through cultured human cancer cells and preclinical approaches, including transgenic and knockout models. These are employed to examine oncogenes and tumor suppressors (e.g., K-ras, APC, MYC) and the influence of chemoprotective agents and anticancer drug candidates. The epigenetic basis of cancer is studied through work on deacetylase inhibitors and changes in protein acetylation in both cancer cells and normal cells treated with dietary agents/anticancer drug candidates. To translate this work to humans, deacetylase expression and protein acetylation changes are examined in volunteers undergoing screening colonoscopy exams.

education and training
selected publications
Academic Articles206
Chapters2
  • Beaver, L. M., Williams, D. E., Dashwood, R. H., & Ho, E. (2012). Chemoprevention of prostate cancer with cruciferous vegetables: Role of epigenetics. Nutrition, Diet and Cancer. (pp. 49-81). Springer Netherlands.
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  • Delage, B., & Dashwood, R. H. (2008). Targeting the epigenome with dietary agents. Dietary Modulation of Cell Signaling Pathways. (pp. 337-369).
Conference Papers35
  • Li, Q., Zhong, X. S., Nyeem, S. Z., Kline, K. T., Peng, J., Fujise, K., & Dashwood, R. H. (2018). Experimental colitis impedes cardiac function through epigenetic mechanisms. Eur Heart J. 39, 994-995.
  • Kaiser, M. C., Rajendran, P., Dashwood, M. W., Levine, M. A., Michaels, A., Frei, B., & Dashwood, R. H. (2013). An epigenetic perspective on pharmacologic ascorbate in colon cancer. The FASEB Journal. 27,
  • Beaver, L. M., Buchanan, A., Sokolowski, E. I., Chang, J. H., Wong, C. P., Williams, D. E., Dashwood, R. H., & Ho, E. (2013). Genome-wide transcriptome analysis of the effects of sulforphane on normal and prostate cancer cells. The FASEB Journal. 27,
  • Atwell, L. L., Clarke, J. D., Hsu, A., Bella, D., Stevens, J. F., Dashwood, R. H., Williams, D. E., & Ho, E. (2013). Sulforaphane bioavailability and bioactivity in humans. The FASEB Journal. 27,
  • Romagnolo, D. F., Dashwood, R., Stover, P. J., Waterland, R. A., & Ziegler, T. R. (2012). Nutritional Regulation of Epigenetic Changes. Advances in Nutrition. 3(5), 749-750.
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recent teaching activities
chaired theses and dissertations
Email
rdashwood@tamu.edu
First Name
Roderick
Last Name
Dashwood
mailing address
Texas A&M Health Science Center; Ibt Center For Translational Cancer Research; 1201 TAMUS
Houston, TX 77030-3303
USA

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