The current focus is on genetic and epigenetic mechanisms in cancer development. The genetic basis of cancer is studied through cultured human cancer cells and preclinical approaches, including transgenic and knockout models. These are employed to examine oncogenes and tumor suppressors (e.g., K-ras, APC, MYC) and the influence of chemoprotective agents and anticancer drug candidates. The epigenetic basis of cancer is studied through work on deacetylase inhibitors and changes in protein acetylation in both cancer cells and normal cells treated with dietary agents/anticancer drug candidates. To translate this work to humans, deacetylase expression and protein acetylation changes are examined in volunteers undergoing screening colonoscopy exams.
- Oregon State University - (Corvallis, Oregon, United States), Postdoctoral Training 1990
- Ph.D. in Genetic Toxicology, University of Portsmouth - (Portsmouth, Portsmouth, United Kingdom) 1986
- M.S. in Toxicology, University of Surrey - (Guildford, Surrey, United Kingdom) 1983
- B.S. in Biological Sciences (Cellular Toxicology), Plymouth University - (Plymouth, Plymouth, United Kingdom) 1982
- Johnson, G. S., Rajendran, P., & Dashwood, R. H. (2020). CCAR1 and CCAR2 as gene chameleons with antagonistic duality: Preclinical, human translational, and mechanistic basis. Cancer Sci.
- Bhattacharjee, S., Li, J., & Dashwood, R. H. (2020). Emerging crosstalk between long non-coding RNAs and Nrf2 signaling. Cancer Letters. 490, 154-164.
- Rajendran, P., Johnson, G., Li, L. i., Chen, Y., Dashwood, M., Nguyen, N., ... Dashwood, R. (2019). Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition. CANCER RESEARCH. 79(5), 918-927.
- Kline, K. T., Lian, H., Zhong, X. S., Luo, X., Winston, J. H., Cong, Y., ... Li, Q. (2019). Neonatal Injury Increases Gut Permeability by Epigenetically Suppressing E-Cadherin in Adulthood.. JOURNAL OF IMMUNOLOGY. ji1900639-ji1900639.
- Zhang, Z., Garzotto, M., Davis, E. W., Mori, M., Stoller, W. A., Farris, P. E., ... Shannon, J. (2019). Sulforaphane Bioavailability and Chemopreventive Activity in Men Presenting for Biopsy of the Prostate Gland: A Randomized Controlled Trial. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL. 1-14.
- Beaver, L. M., Williams, D. E., Dashwood, R. H., & Ho, E. (2012). Chemoprevention of prostate cancer with cruciferous vegetables: Role of epigenetics. Nutrition, Diet and Cancer. (pp. 49-81). Springer Netherlands.
- Delage, B., & Dashwood, R. H. (2008). Targeting the epigenome with dietary agents. Dietary Modulation of Cell Signaling Pathways. (pp. 337-369).
- Li, Q., Zhong, X. S., Nyeem, S. Z., Kline, K. T., Peng, J., Fujise, K., & Dashwood, R. H. (2018). Experimental colitis impedes cardiac function through epigenetic mechanisms. Eur Heart J. 39, 994-995.
- Kaiser, M. C., Rajendran, P., Dashwood, M. W., Levine, M. A., Michaels, A., Frei, B., & Dashwood, R. H. (2013). An epigenetic perspective on pharmacologic ascorbate in colon cancer. The FASEB Journal. 27,
- Beaver, L. M., Buchanan, A., Sokolowski, E. I., Chang, J. H., Wong, C. P., Williams, D. E., Dashwood, R. H., & Ho, E. (2013). Genome-wide transcriptome analysis of the effects of sulforphane on normal and prostate cancer cells. The FASEB Journal. 27,
- Atwell, L. L., Clarke, J. D., Hsu, A., Bella, D., Stevens, J. F., Dashwood, R. H., Williams, D. E., & Ho, E. (2013). Sulforaphane bioavailability and bioactivity in humans. The FASEB Journal. 27,
- Romagnolo, D. F., Dashwood, R., Stover, P. J., Waterland, R. A., & Ziegler, T. R. (2012). Nutritional Regulation of Epigenetic Changes. Advances in Nutrition. 3(5), 749-750.
- CCAR2 as a Target for Prevention of Colorectal Cancer awarded by DHHS-NIH-National Cancer Institute 2018 - 2023