Adams, Leslie individual record
Senior Professor - Term Appointment
overview

My research is focused on the: 1) investigation of the comparative molecular pathogenesis of zoonotic intracellular bacterial pathogens in natural animal models, particularly brucellosis, salmonellosis, and mycobacterial diseases; 2) development of vaccines and host gene expression-based diagnostics for zoonotic and select agent caused diseases, and especially 3) development of in silico host:pathogen interactome predictive models based upon bi-directional in vivo host (bovine/murine) and Brucella spp., Mycobacterium spp.and Salmonella enterica Typhimurium interactions. We developed an in silico computational infection biology model based on actuall temporal in vivo bovine model microarray-based transcriptomic and proteomic profiling of the acute infectious process. We developed a systems biology analysis of both host and pathogen comprehensive transcriptomic and proteomic datasets derived from our in vivo biological model. We computationally fused the datasets based on actual Salmonella, Brucella and Mycobacterium data and computationally predicted bovine host structural proteins to identify maximum likelihoods of host and pathogen protein:protein interactions as the basis for our preliminary in silico interactome model to predict mechanistic genes and linked perturbed cellular pathways.

selected publications
Academic Articles220
  • Saenkham-Huntsinger, P., Hyre, A. N., Hanson, B. S., Donati, G. L., Adams, L. G., Ryan, C., ... Subashchandrabose, S. (2021). Copper Resistance Promotes Fitness of Methicillin-Resistant Staphylococcus aureus during Urinary Tract Infection. mBio. 12(5), e02038-e02021.
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  • Dow, A., Sule, P., O’Donnell, T. J., Burger, A., Mattila, J. T., Antonio, B., ... Prisic, S. (2021). Zinc limitation triggers anticipatory adaptations in Mycobacterium tuberculosis. 17(5), e1009570-e1009570.
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  • Cooper, K. G., Chong, A., Kari, L., Jeffrey, B., Starr, T., Martens, C., ... Steele-Mortimer, O (2021). Regulatory protein HilD stimulates Salmonella Typhimurium invasiveness by promoting smooth swimming via the methyl-accepting chemotaxis protein McpC.. Nat Commun. 12(1), 348.
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  • Adetunji, S. A., Faustman, D. L., Adams, L. G., Garcia-Gonzalez, D. G., Hensel, M. E., Khalaf, O. H., & Arenas-Gamboa, A. M (2020). Brucella abortus and Pregnancy in Mice: Impact of Chronic Infection on Fertility and the Role of Regulatory T Cells in Tissue Colonization.. Infect Immun. 88(10),
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  • Saenkham, P., Jennings-Gee, J., Hanson, B., Kock, N. D., Adams, L. G., & Subashchandrabose, S. (2020). Hyperglucosuria induced by dapagliflozin augments bacterial colonization in the murine urinary tract.. Diabetes Obes Metab. 22(9), 1548-1555.
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Chapters8
  • Köhler, S., Hanna, N., Ouahrani‐Bettache, S., Drake, K. L., Adams, L. G., & Occhialini, A. (2016). Global Rsh‐Dependent Transcription Profile of Brucella Suis During Stringent Response Unravels Adaptation to Nutrient Starvation and Cross‐Talk with Other Stress Responses. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria. 489-499. John Wiley & Sons, Inc..
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  • Ficht, T. A., & Adams, L. G. (2009). Brucellosis. Vaccines for Biodefense and Emerging and Neglected Diseases. 807-829. Elsevier.
  • Adams, L. G., Babiuk, L., McGavin, D., & Nordgren, R. (2009). Special Issues around Veterinary Vaccines. Vaccines for Biodefense and Emerging and Neglected Diseases. 225-254. Elsevier.
  • Adams, L. G., Babiuk, L., McGavin, D., & Nordgren, R. (2009). Chapter 16 Special Issues around Veterinary Vaccines. Vaccines for Biodefense and Emerging and Neglected Diseases. 225-254.
  • Ficht, T. A., & Adams, L. G. (2009). Chapter 42 Brucellosis. Vaccines for Biodefense and Emerging and Neglected Diseases. 807-829.
Conference Papers7
  • Tsolis, R. M., Kingsley, R. A., Townsend, S. M., Ficht, T. A., Adams, L. G., & Bumler, A. J. (1999). Of Mice, Calves, and Men. 473, 261-274.
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  • Adams, L. G., & Templeton, J. W. (1993). Selection experiments to alter disease resistance traits in domestic animals. 38(3-4), 387-394.
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  • ADAMS, L. G. (1990). DEVELOPMENT OF LIVE BRUCELLA VACCINES. 250-276.
  • CRAWFORD, R. P., ADAMS, L. G., WILLIAMS, J. D., & DIETRICH, R. A. (1990). ECONOMIC-LOSSES ATTRIBUTABLE TO BRUCELLOSIS. 357-372.
  • SMITH, R., KAPATSA, J., FICHT, T. A., & ADAMS, L. G. (1988). DIFFERENTIAL RECOGNITION OF BRUCELLAE BY BOVINE T-CELLS. 2(4), A882-A882.
patents
Patents3
chaired theses and dissertations
Email
gadams@tamu.edu
First Name
Leslie
Last Name
Adams
mailing address
Texas A&M University; Vet Med Pathobiology; 4467 TAMU
College Station, TX 77843-4467
USA