overview

My research is focused on the: 1) investigation of the comparative molecular pathogenesis of zoonotic intracellular bacterial pathogens in natural animal models, particularly brucellosis, salmonellosis, and mycobacterial diseases; 2) development of vaccines and host gene expression-based diagnostics for zoonotic and select agent caused diseases, and especially 3) development of in silico host:pathogen interactome predictive models based upon bi-directional in vivo host (bovine/murine) and Brucella spp., Mycobacterium spp.and Salmonella enterica Typhimurium interactions. We developed an in silico computational infection biology model based on actuall temporal in vivo bovine model microarray-based transcriptomic and proteomic profiling of the acute infectious process. We developed a systems biology analysis of both host and pathogen comprehensive transcriptomic and proteomic datasets derived from our in vivo biological model. We computationally fused the datasets based on actual Salmonella, Brucella and Mycobacterium data and computationally predicted bovine host structural proteins to identify maximum likelihoods of host and pathogen protein:protein interactions as the basis for our preliminary in silico interactome model to predict mechanistic genes and linked perturbed cellular pathways.

selected publications
Academic Articles238
  • Farris, L. C., Torres-Odio, S., Adams, L. G., West, A. P., & Hyde, J. A. (2023). Borrelia burgdorferi Engages Mammalian Type I IFN Responses via the cGAS-STING Pathway.. J Immunol. 210(11), 1761-1770.
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  • Bogomolnaya, L., Talamantes, M., Rocha, J., Nagarajan, A., Zhu, W., Spiga, L., ... Andrews-Polymenis, H. (2023). Taxonomic and Metagenomic Analyses Define the Development of the Microbiota in the Chick.. mBio. 14(1), e0244422-e02422.
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  • Scoggin, K., Gupta, J., Lynch, R., Nagarajan, A., Aminian, M., Peterson, A., ... Andrews-Polymenis, H. L. (2022). Elucidating Mechanisms of Tolerance to Salmonella Typhimurium across Long-Term Infections Using the Collaborative Cross.. mBio. 13(4), e0112022-e01122.
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  • Scoggin, K., Lynch, R., Gupta, J., Nagarajan, A., Sheffield, M., Elsaadi, A., ... Andrews-Polymenis, H. L. (2022). Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross.. PLoS Genet. 18(4), e1010075-e1010075.
  • Robinson, C. K., Saenkham-Huntsinger, P., Hanson, B. S., Adams, L. G., & Subashchandrabose, S. (2022). Vaginal Inoculation of Uropathogenic Escherichia coli during Estrus Leads to Genital and Renal Colonization.. Infect Immun. 90(4), e0053221-e00521.
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Chapters9
  • Khler, S., Hanna, N., OuahraniBettache, S., Drake, K. L., Adams, L. G., & Occhialini, A. (2016). Global RshDependent Transcription Profile of Brucella Suis During Stringent Response Unravels Adaptation to Nutrient Starvation and CrossTalk with Other Stress Responses. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria. 489-499. Wiley.
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  • Ficht, T. A., & Adams, L. G. (2009). Brucellosis. VACCINES FOR BIODEFENSE AND EMERGING AND NEGLECTED DISEASES. 807-829. Elsevier.
  • Adams, L. G., Babiuk, L., McGavin, D., & Nordgren, R. (2009). Special Issues around Veterinary Vaccines. VACCINES FOR BIODEFENSE AND EMERGING AND NEGLECTED DISEASES. 225-254. Elsevier.
  • Adams, L. G., Babiuk, L., McGavin, D., & Nordgren, R. (2009). Chapter 16 Special Issues around Veterinary Vaccines. Vaccines for Biodefense and Emerging and Neglected Diseases. 225-254. Elsevier.
  • Ficht, T. A., & Adams, L. G. (2009). Chapter 42 Brucellosis. Vaccines for Biodefense and Emerging and Neglected Diseases. 807-829. Elsevier.
Conference Papers7
  • Tsolis, R. M., Kingsley, R. A., Townsend, S. M., Ficht, T. A., Adams, L. G., & Bumler, A. J. (1999). Of mice, calves, and men. Comparison of the mouse typhoid model with other Salmonella infections.. Adv Exp Med Biol. 473, 261-274.
  • Adams, L. G., & Templeton, J. W. (1993). Selection experiments to alter disease resistance traits in domestic animals.. Vet Immunol Immunopathol. 38(3-4), 387-394.
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  • ADAMS, L. G. (1990). DEVELOPMENT OF LIVE BRUCELLA VACCINES. ADVANCES IN BRUCELLOSIS RESEARCH. 250-276.
  • CRAWFORD, R. P., ADAMS, L. G., WILLIAMS, J. D., & DIETRICH, R. A. (1990). ECONOMIC-LOSSES ATTRIBUTABLE TO BRUCELLOSIS. ADVANCES IN BRUCELLOSIS RESEARCH. 357-372.
  • SMITH, R., KAPATSA, J., FICHT, T. A., & ADAMS, L. G. (1988). DIFFERENTIAL RECOGNITION OF BRUCELLAE BY BOVINE T-CELLS. FASEB JOURNAL. 2(4), A882-A882.
Repository Documents / Preprints4
  • Bogomolnaya, L., Talamantes, M., Rocha, J., Nagarajan, A., Zhu, W., Spiga, L., ... Andrews-Polymenis, H. (2022). Taxonomic and metagenomic analyses define the development of the microbiota in the chick.
    doi badge online source badge
  • Farris, L. C., Torres-Odio, S., Adams, L. G., West, A. P., & Hyde, J. A. (2022). Borrelia burgdorferi engages mammalian type I interferon responses via the cGAS-STING pathway.
    doi badge
  • Scoggin, K., Gupta, J., Lynch, R., Nagarajan, A., Aminian, M., Peterson, A., ... Andrews-Polymenis, H. L. (2022). Elucidating Mechanisms of Tolerance to Salmonella Typhimurium Across Long-Term Infections Using the Collaborative Cross.
  • Scoggin, K., Lynch, R., Gupta, J., Nagarajan, A., Sheffield, M., Elsaadi, A., ... Andrews-Polymenis, H. (2022). Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross.
patents
Patents3
chaired theses and dissertations
Email
gadams@tamu.edu
First Name
Leslie
Last Name
Adams
mailing address
Texas A&M University; Vet Med Pathobiology; 4467 TAMU
College Station, TX 77843-4467
USA