West, A. Phillip individual record
Assistant Professor
overview

Mitochondria are complex and dynamic organelles integral to many processes including energy generation, programmed cell death, signal transduction, and immunity. Research in my laboratory centers on understanding how mitochondria regulate innate immunity and inflammatory processes to influence human health and disease.

education and training
selected publications
Academic Articles29
  • Scott, K., Phan, T. T., West, A. P., Taniguchi, C. M., & Dantzer, R. (2022). Neutralizing interleukin-6 in tumor-bearing mice does not abrogate behavioral fatigue induced by Lewis lung carcinoma.. Behav Brain Res.
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  • Sutherland, T. C., Sefiani, A., Horvat, D., Huntington, T. E., Lei, Y., West, A. P., & Geoffroy, C. G. (2021). Age-Dependent Decline in Neuron Growth Potential and Mitochondria Functions in Cortical Neurons.. Cells. 10(7), 1625-1625.
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  • Torres-Odio, S., Lei, Y., Gispert, S., Maletzko, A., Key, J., Menissy, S. S., ... West, A. P. (2021). Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis.. J Immunol. 206(8), 1890-1900.
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  • Lei, Y., Guerra Martinez, C., Torres-Odio, S., Bell, S. L., Birdwell, C. E., Bryant, J. D., ... West, A. P. (2021). Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice.. Sci Adv. 7(22), eabe7548.
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  • Key, J., Torres-Odio, S., Bach, N. C., Gispert, S., Koepf, G., Reichlmeir, M., ... Auburger, G. (2021). Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA.. Cells. 10(12), 3354-3354.
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Books1
  • West, A. P., Koblansky, A. A., & Ghosh, S (2006). Recognition and signaling by toll-like receptors.. Annual Reviews.
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Repository Documents / Preprints5
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  • Lei, Y., VanPortfliet, J. J., Chen, Y., Bryant, J. D., Ragan, K. B., Tong, C. W., ... West, A. P. (2022). ZBP1 sequesters cGAS in the cytoplasm and sustains type I interferon responses to mitochondrial DNA.
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  • Key, J., Torres-Odio, S., Bach, N. C., Gispert, S., Koepf, G., Reichlmeir, M., ... Auburger, G. (2021). Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX With Its Interactors at the Nucleoid and RNA Granule.
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  • Torres-Odio, S., Lei, Y., Gispert, S., Maletzko, A., Key, J., Menissy, S., ... West, A. P. (2020). Loss of mitochondrial protease CLPP activates type I interferon responses through the mtDNA-cGAS-STING signaling axis.
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Email
awest@tamu.edu
First Name
A. Phillip
Last Name
West
mailing address
Texas A&M Health Science Center; Microbial Pathogenesis And Immunology; 1114 TAMUS
College Station, TX 77843-1113
USA