Scholars

overview

The Zhou Lab at Texas A&M is exploring the fascinating frontiers of calcium signaling, optogenteics, epigenetics, immunoengieerning and molecular therapy research with a focus on elucidating the role of calcium channels and DNA modifications in health and diseases and designing better treatment and prevention strategies for cardivaslcuar disorders, autoimmune diseases and cancer. We are particularly interested in understanding how calcium ions are transported across membrane, how ion channels and human epigenome in cells of the immune system can be engineered to achieve tailored function, and how dysregulated ion homeostasis and DNA modifictaions lead to human diseases.

education and training

Ph.D. in Chemistry, Georgia State University - (Atlanta, Georgia, United States) 2008
M.S. in Chemistry, Georgia State University - (Atlanta, Georgia, United States) 2007
M.D. in Internal Medicine, Zhejiang University - (Hangzhou, Zhejiang, China) 2003

selected publications

Academic Articles87

Ma, G., & Zhou, Y. (2020). A STIMulating journey into optogenetic engineering. CELL CALCIUM. 88, 102197-102197.
Yang, X., Ma, G., Zheng, S., Qin, X., Li, X., Du, L., ... Li, M. (2020). Optical Control of CRAC Channels Using Photoswitchable Azopyrazoles.. Journal of the American Chemical Society. 142(20), 9460-9470.
Guo, L., Li, J., Zeng, H., Guzman, A. G., Li, T., Lee, M., ... Huang, Y. (2020). A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells.. Nature Communications. 11(1), 740.
Ma, G., He, L., Liu, S., Xie, J., Huang, Z., Jing, J. i., ... Zhou, Y. (2020). Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling.. Nature Communications. 11(1), 1039.
Haruehanroengra, P., Zheng, Y. Y., Zhou, Y., Huang, Y., & Sheng, J. (2020). RNA Modifications and Cancer.. RNA biology. 1-16.

Chapters6

Ma, G., He, L., Jing, J., Tan, P., Huang, Y., & Zhou, Y. (2018). Engineered Cross-Linking to Study the Pore Architecture of the CRAC Channel. Methods in molecular biology (Clifton, N.J.). Methods in Molecular Biology. (pp. 147-166). Springer New York.
Zhang, S., He, L., Zhou, Y., & Wang, Y. (2018). Fluorescence-Based Ratiometric Measurement of CRAC Channel Activity in STIM-Orai-Overexpressing HEK-293 Cells. Methods in molecular biology (Clifton, N.J.). The CRAC Channel. (pp. 17-39). Springer New York.
Zhang, Y., Zheng, S., Zhou, Y., Gill, D. L., & Wang, Y. (2018). Patch-Clamp Recording of the CRAC Channel Current in STIM-Orai Overexpressing Cells. Methods in molecular biology (Clifton, N.J.). The CRAC Channel. (pp. 1-16). Springer New York.
He, L., Zhang, Q., Zhou, Y., & Huang, Y. (2017). Optogenetic approaches to control calcium entry in non-excitable cells. Calcium Entry Channels in Non-Excitable Cells. (pp. 145-160). CRC Press.
Ma, G., Wen, S., Huang, Y., & Zhou, Y. (2017). The STIM-orai pathway: Light-operated Ca²⁺entry through engineered CRAC channels. Advances in Experimental Medicine and Biology. (pp. 117-138). Springer International Publishing.

teaching activities

IBST605 Biomed Rsrch Prfsnl Dvlpmnt Instructor
IBST691 Research Credit: Medical Sci Instructor

Email

yubinzhou@tamu.edu

First Name

Yubin

Last Name

Zhou

mailing address

Texas A&M University -IBT; Ibt Center For Translational Cancer Research; 1201 TAMUS

Houston, TX 77030-3303

USA

SCHOLARS@TAMU

Academic Articles87

Chapters6