Scholars

Associate Professor

Positions:

Associate Professor, Institute of Biosciences and Technology

Research Areas:

DNA--Methylation, Calcium channels, Ion channels, Cancer--Research, Optogenetics, Epigenetics, Immunology, Cancer--Treatment

Single Page Bio

yubinzhou@tamu.edu

1 713 677 7483

Co-author Network

Map of Science

Co-investigator Network

Websites

Yubin Zhou Lab

ORCID

0000-0001-7962-0517

Research Areas:

DNA--Methylation, Calcium channels, Ion channels, Cancer--Research, Optogenetics, Epigenetics, Immunology, Cancer--Treatment

overview

The Zhou Lab at Texas A&M is exploring the fascinating frontiers of calcium signaling, optogenteics, epigenetics, immunoengieerning and molecular therapy research with a focus on elucidating the role of calcium channels and DNA modifications in health and diseases and designing better treatment and prevention strategies for cardivaslcuar disorders, autoimmune diseases and cancer. We are particularly interested in understanding how calcium ions are transported across membrane, how ion channels and human epigenome in cells of the immune system can be engineered to achieve tailored function, and how dysregulated ion homeostasis and DNA modifictaions lead to human diseases.

education and training

Ph.D. in Chemistry, Georgia State University - (Atlanta, Georgia, United States) 2008
M.S. in Chemistry, Georgia State University - (Atlanta, Georgia, United States) 2007
M.D. in Internal Medicine, Zhejiang University - (Hangzhou, Zhejiang, China) 2003

selected publications

Academic Articles100

He, L., Tan, P., Zhu, L., Huang, K., Nguyen, N. T., Wang, R., ... Zhou, Y. (2021). Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering. Nature Chemical Biology. 1-9.
Li, L., He, L., Wu, B. o., Yu, C., Zhao, H., Zhou, Y., Wang, J., & Zhu, L. (2021). Structural Determinants for Light-Dependent Membrane Binding of a Photoswitchable Polybasic Domain.. ACS Synth Biol. 10(3), 542-551.
He, L., Tan, P., Huang, Y., & Zhou, Y. (2021). Design of Smart Antibody Mimetics with Photosensitive Switches. Adv Biol (Weinh). 5(5), e2000541-2000541.
He, L., Wang, L., Zeng, H., Tan, P., Ma, G., Zheng, S., ... Zhou, Y. (2021). Engineering of a bona fide light-operated calcium channel. Nature Communications. 12(1), 164.
Guo, L., Lee, Y., Zhou, Y., & Huang, Y. (2021). Targeting epigenetic regulatory machinery to overcome cancer therapy resistance. Seminars in Cancer Biology.

Chapters6

Ma, G., He, L., Jing, J. i., Tan, P., Huang, Y., & Zhou, Y. (2018). Engineered Cross-Linking to Study the Pore Architecture of the CRAC Channel. Methods in Molecular Biology. The CRAC Channel. (pp. 147-166). Springer New York.
Zhang, S., He, L., Zhou, Y., & Wang, Y. (2018). Fluorescence-Based Ratiometric Measurement of CRAC Channel Activity in STIM-Orai-Overexpressing HEK-293 Cells. Methods in Molecular Biology. The CRAC Channel. (pp. 17-39). Springer New York.
Zhang, Y., Zheng, S., Zhou, Y., Gill, D. L., & Wang, Y. (2018). Patch-Clamp Recording of the CRAC Channel Current in STIM-Orai Overexpressing Cells. Methods in Molecular Biology. The CRAC Channel. (pp. 1-16). Springer New York.
Ma, G., Wen, S., Huang, Y., & Zhou, Y. (2017). The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channels. MATHEMATICAL MODELLING IN EXPERIMENTAL NUTRITION. Store-Operated Ca²⁺ Entry (SOCE) Pathways. (pp. 117-138). Springer International Publishing.
He, L., Zhang, Q., Zhou, Y., & Huang, Y. (2017). Optogenetic approaches to control calcium entry in non-excitable cells. Calcium Entry Channels in Non-Excitable Cells. (pp. 145-160). CRC Press.