Scholars

Professor & Presidential Impact Fellow

Positions:

Associate Professor, Institute of Biosciences and Technology, College of Medicine

Research Areas:

DNA--Methylation, Calcium channels, Ion channels, Chemical biology, Cancer--Research, Cancer--Immunotherapy, Optogenetics, Nanotechnology, Epigenetics, Immunology, Bioengineering, Cancer--Treatment

UN Sustainable Development Goals:

Single Page Bio

Profile Summary

yubinzhou@tamu.edu

1 713 677 7483

Co-author Network

Map of Science

Co-investigator Network

Websites

Yubin Zhou Lab

ORCID

0000-0001-7962-0517

UN Sustainable Development Goals:

Research Areas:

DNA--Methylation, Calcium channels, Ion channels, Chemical biology, Cancer--Research, Cancer--Immunotherapy, Optogenetics, Nanotechnology, Epigenetics, Immunology, Bioengineering, Cancer--Treatment

Twitter

Tweets by @ibtzhoulab

overview

We are a synthetic biology and bioengineering lab focused on developing technologies that enable remote and programmable control of protein activity, cell signaling and designer cells. We pioneer chemical and synthetic biology approaches to address challenges in health and disease. We are particularly interested in (i) illuminating novel regulatory mechanisms of signal transduction that remain unresolved in Ca2+ signaling and inter-organelle communications; (ii) pioneering widely-applicable molecular tools for precise control of cellular events, (epi)genome engineering, and gene transcription; and (iii) developing innovative theranostic devices, programmable biologics and intelligent cell-based therapies (CAR-T) for cancer and neurodegeneration intervention. The tight integration among mechanistic studies, biomedical engineering, and translational sciences is a hallmark of my research. See highlights in: "Let there be light" (Scientia); "Optogenetics sparks new research tool" (NIH Biomedical Beat)

education and training

Ph.D. in Chemistry, Georgia State University - (Atlanta, Georgia, United States) 2008
M.S. in Chemistry, Georgia State University - (Atlanta, Georgia, United States) 2007
M.D. in Internal Medicine, Zhejiang University - (Hangzhou, Zhejiang, China) 2003

selected publications

Academic Articles99

Nguyen, N. T., Huang, K., Zeng, H., Jing, J. i., Wang, R., Fang, S., ... Zhou, Y. (2021). Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety. Nature Nanotechnology. 16(12), 1424-1434.

SDG 3
He, L., Huang, Z., Huang, K., Chen, R., Nguyen, N. T., Wang, R., ... Jing, J. i. (2021). Optogenetic Control of Non‐Apoptotic Cell Death. Advanced Science. 8(13), 2100424-2100424.
He, L., Tan, P., Zhu, L., Huang, K., Nguyen, N. T., Wang, R., ... Zhou, Y. (2021). Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering.. Nat Chem Biol. 17(8), 915-923.
He, L., Tan, P., Huang, Y., & Zhou, Y. (2021). Design of Smart Antibody Mimetics with Photosensitive Switches.. Adv Biol (Weinh). 5(5), e2000541-2000541.

SDG 3
Tan, P., He, L., & Zhou, Y. (2021). Engineering Supramolecular Organizing Centers for Optogenetic Control of Innate Immune Responses.. Adv Biol (Weinh). 5(5), e2000147-2000147.

Chapters7

Mao, J., Lin, E., He, L., Yu, J., Tan, P., & Zhou, Y. (2019). Autophagy and Viral Infection.. MATHEMATICAL MODELLING IN EXPERIMENTAL NUTRITION. Advances in Experimental Medicine and Biology. 55-78. Springer Singapore.
Ma, G., He, L., Jing, J. i., Tan, P., Huang, Y., & Zhou, Y. (2018). Engineered Cross-Linking to Study the Pore Architecture of the CRAC Channel.. Methods Mol Biol. The CRAC Channel. 147-166. Springer New York.
Zhang, S., He, L., Zhou, Y., & Wang, Y. (2018). Fluorescence-Based Ratiometric Measurement of CRAC Channel Activity in STIM-Orai-Overexpressing HEK-293 Cells.. Methods Mol Biol. The CRAC Channel. 17-39. Springer New York.
Zhang, Y., Zheng, S., Zhou, Y., Gill, D. L., & Wang, Y. (2018). Patch-Clamp Recording of the CRAC Channel Current in STIM-Orai Overexpressing Cells.. Methods Mol Biol. The CRAC Channel. 1-16. Springer New York.
He, L., Zhang, Q., Zhou, Y., & Huang, Y. (2017). Calcium Entry Channels in Non-Excitable Cells. Kozak, J. A., & Putney, J. W. (Eds.), Calcium Entry Channels in Non-Excitable Cells. 145-160. CRC Press.