Zhou, Yubin individual record
Professor & Presidential Impact Fellow

We are a synthetic biology and bioengineering lab focused on developing technologies that enable remote and programmable control of protein activity, cell signaling and designer cells. We pioneer chemical and synthetic biology approaches to address challenges in health and disease. We are particularly interested in (i) illuminating novel regulatory mechanisms of signal transduction that remain unresolved in Ca2+ signaling and inter-organelle communications; (ii) pioneering widely-applicable molecular tools for precise control of cellular events, (epi)genome engineering, and gene transcription; and (iii) developing innovative theranostic devices, programmable biologics and intelligent cell-based therapies (CAR-T) for cancer and neurodegeneration intervention. The tight integration among mechanistic studies, biomedical engineering, and translational sciences is a hallmark of my research. See highlights in: "Let there be light" (Scientia); "Optogenetics sparks new research tool" (NIH Biomedical Beat)

selected publications
Academic Articles99
  • Nguyen, N. T., Huang, K., Zeng, H., Jing, J. i., Wang, R., Fang, S., ... Zhou, Y. (2021). Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety. Nature Nanotechnology. 16(12), 1424-1434.
  • He, L., Huang, Z., Huang, K., Chen, R., Nguyen, N. T., Wang, R., ... Jing, J. i. (2021). Optogenetic Control of Non‐Apoptotic Cell Death. Advanced Science. 8(13), 2100424-2100424.
    doi badge
  • He, L., Tan, P., Zhu, L., Huang, K., Nguyen, N. T., Wang, R., ... Zhou, Y. (2021). Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering.. Nat Chem Biol. 17(8), 915-923.
    doi badge pubmed badge
  • He, L., Tan, P., Huang, Y., & Zhou, Y. (2021). Design of Smart Antibody Mimetics with Photosensitive Switches.. Adv Biol (Weinh). 5(5), e2000541-2000541.
  • Tan, P., He, L., & Zhou, Y. (2021). Engineering Supramolecular Organizing Centers for Optogenetic Control of Innate Immune Responses.. Adv Biol (Weinh). 5(5), e2000147-2000147.
    doi badge pubmed badge
  • Mao, J., Lin, E., He, L., Yu, J., Tan, P., & Zhou, Y. (2019). Autophagy and Viral Infection.. MATHEMATICAL MODELLING IN EXPERIMENTAL NUTRITION. Advances in Experimental Medicine and Biology. 55-78. Springer Singapore.
    doi badge pubmed badge
  • Ma, G., He, L., Jing, J. i., Tan, P., Huang, Y., & Zhou, Y. (2018). Engineered Cross-Linking to Study the Pore Architecture of the CRAC Channel.. Methods Mol Biol. The CRAC Channel. 147-166. Springer New York.
    doi badge pubmed badge
  • Zhang, S., He, L., Zhou, Y., & Wang, Y. (2018). Fluorescence-Based Ratiometric Measurement of CRAC Channel Activity in STIM-Orai-Overexpressing HEK-293 Cells.. Methods Mol Biol. The CRAC Channel. 17-39. Springer New York.
    doi badge pubmed badge
  • Zhang, Y., Zheng, S., Zhou, Y., Gill, D. L., & Wang, Y. (2018). Patch-Clamp Recording of the CRAC Channel Current in STIM-Orai Overexpressing Cells.. Methods Mol Biol. The CRAC Channel. 1-16. Springer New York.
    doi badge pubmed badge
  • He, L., Zhang, Q., Zhou, Y., & Huang, Y. (2017). Calcium Entry Channels in Non-Excitable Cells. Kozak, J. A., & Putney, J. W. (Eds.), Calcium Entry Channels in Non-Excitable Cells. 145-160. CRC Press.
    doi badge
Conference Papers5
  • Lee, M., Li, J., Li, J., Fang, S., Zhang, J., Vo, A., ... Huang, Y. (2021). Tet2 Inactivation Enhances the Antitumor Activity of Tumor-Infiltrating Lymphocytes.. Cancer Res. 81(8), 1965-1976.
    doi badge pubmed badge
  • Ma, G., He, L., & Zhou, Y. (2021). Identification of A STIM1 Splicing Variant that Promotes Tumor Growth. BIOPHYSICAL JOURNAL. 120(3), 54A-54A.
  • Fang, S., Xiao, Y., Li, J., Li, T., Zeng, H., Han, W., ... Huang, Y. (2018). Tet2 Deficiency in Macrophages Undermines Heart Repair after Infarction. Blood. 132(Supplement 1), 2394-2394.
    doi badge
  • Gudlur, A., Quintana, A., Zhou, Y., Rao, A., & Hogan, P. G. (2014). Mechanism of Activation of Calcium Channel Orai1 by its Regulatory Partner Stim1. Biophysical Journal. 106(2), 315a-315a.
    doi badge
  • Chen, Y., Zhou, Y., Wong, H., Lin, X., Xu, Q., Lurtz, M. M., ... Yang, J. J. (2010). Cam Interaction and Binding Mode Study with Peptide from Intracellular Loop of Cx50. Biophysical Journal. 98(3), 94a-94a.
    doi badge
recent teaching activities
First Name
Last Name
mailing address
Texas A&M University -IBT; Ibt Center For Translational Cancer Research; 1201 TAMUS
Houston, TX 77030-3303