overview
Our laboratory conducts translational research with an ultimate goal to discover new anti-parasitic therapeutics by targeting metabolic enzymes and other molecules critical or essential to the parasite infection, survival and development, such as those involved in the lipid and energy metabolisms and interacting with host cells in Cryptosporidium and other protozoan parasites. Other research areas include functional genomics and molecular evolution of apicomplexan parasites, and parasitic diseases important to the conservation of wild animals.
education and training
- Wadsworth Center - (Albany, New York, United States), Postdoctoral Training 1996
- Ph.D. in Poultry/Parasitology, University of Georgia - (Athens, Georgia, United States) 1993
- M.S. in Zoology/Parasitology, Zhejiang University - (Hangzhou, Zhejiang, China) 1986
- B.S. in Biology, Zhejiang University - (Hangzhou, Zhejiang, China) 1983
selected publications
Academic Articles102
- Ma, J., Guo, F., Jin, Z. i., Geng, M., Ju, M., Ravichandran, A., ... Zhang, H. (2020). Novel Antiparasitic Activity of the Antifungal Lead Occidiofungin.. Antimicrobial Agents and Chemotherapy. 64(8),
- Zhu, G., & Liu, M. (2020). An old drug as a promising new cure for the hard-to-treat echinococcosis. EBioMedicine. 55, 102749-102749.
- Yu, X., Guo, F., Mouneimne, R. B., & Zhu, G. (2019). Cryptosporidium parvum elongation factor 1α (CpEF1α) participates in the formation of base structure at the infection site during invasion. The Journal of Infectious Diseases. 221(11), 1816-1825.
- Jin, Z. i., Ma, J., Zhu, G., & Zhang, H. (2019). Discovery of Novel Anti-cryptosporidial Activities From Natural Products by in vitro High-Throughput Phenotypic Screening. Frontiers in Microbiology. 10(AUG), 1999.
- Guo, F., Zhang, H., Eltahan, R., & Zhu, G. (2019). Molecular and Biochemical Characterization of a Type II Thioesterase From the Zoonotic Protozoan Parasite Cryptosporidium parvum. Frontiers in Cellular and Infection Microbiology. 9(JUN), 199.
Chapters3
- Zhang, H., & Zhu, G. (2020). High-Throughput Screening of Drugs Against the Growth of Cryptosporidium parvum In Vitro by qRT-PCR. Methods in Molecular Biology. Cryptosporidium. (pp. 319-334). Springer New York.
- Zhu, G., & Guo, F. (2014). Cryptosporidium Metabolism. Cryptosporidium: parasite and disease. (pp. 361-379). Springer Vienna.
- Zhu, G. (2009). Energy metabolism and carbon flow in Cryptosporidium parvum. Giardia and Cryptosporidium: From Molecules to Diseases. (pp. 360-368).
Conference Papers4
- Stejskal, F., Surinova, M., Hrdy, I., Fritzler, J. M., Zhu, G., & Korenkova, V. (2009). Inhibition of the Cryptosporidium parvum S-adenosylhomocysteine hydrolase with purine nucleoside analogues. TROPICAL MEDICINE & INTERNATIONAL HEALTH. 14, 220-220.
- Rider, S. D., & Zhu, G. (2008). An improved histone deacetylase (HDAC) assay and its application for high-throughput screening of inhibitors against Cryptosporidium parvum enzymes. FASEB J. 22,
- Chen, X., Ohara, S. P., Huang, B. Q., Nelson, J. B., Lin, J., Zhu, G., Ward, H. D., & LaRusso, N. F. (2004). Apical organelle discharge by Cryptosporidium parvum is temperature-, cytoskeleton- and intracellular calcium-dependent and required for host cell invasion. MOLECULAR BIOLOGY OF THE CELL. 15, 466A-467A.
- YARLETT, N., MARTINEZ, M. P., ZHU, G., KEITHLY, J. S., WOODS, K., & UPTON, S. J. (1996). Cryptosporidium parvum: Polyamine Biosynthesis from Agmatine. Journal of Eukaryotic Microbiology. 43(5), 73s-73s.
researcher on
Principal Investigator6
Co-Principal Investigator1
recent teaching activities
- VPAR605 Mlclr & Immun Parastlgy Instructor
- VPAT685 Directed Studies Instructor
- VPAT691 Research Instructor
- VPAT691 Research: In-ab Instructor
- VTMI685 Directed Studies Instructor
Email
gzhu@tamu.edu
First Name
Guan
Last Name
Zhu
mailing address
Texas A&M University; Vet Med Pathobiology; 4467 TAMU
College Station, TX 77843-4467
USA