overview

Our laboratory conducts translational research with an ultimate goal to discover new anti-parasitic therapeutics by targeting metabolic enzymes and other molecules critical or essential to the parasite infection, survival and development, such as those involved in the lipid and energy metabolisms and interacting with host cells in Cryptosporidium and other protozoan parasites. Other research areas include functional genomics and molecular evolution of apicomplexan parasites, and parasitic diseases important to the conservation of wild animals.

education and training
selected publications
Academic Articles102
  • Ma, J., Guo, F., Jin, Z. i., Geng, M., Ju, M., Ravichandran, A., ... Zhang, H. (2020). Novel Antiparasitic Activity of the Antifungal Lead Occidiofungin.. Antimicrob Agents Chemother. 64(8),
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  • Zhu, G., & Liu, M. (2020). An old drug as a promising new cure for the hard-to-treat echinococcosis.. EBioMedicine. 55, 102749-102749.
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  • Yu, X., Guo, F., Mouneimne, R. B., & Zhu, G. (2020). Cryptosporidium parvum Elongation Factor 1α Participates in the Formation of Base Structure at the Infection Site During Invasion.. J Infect Dis. 221(11), 1816-1825.
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  • Jin, Z. i., Ma, J., Zhu, G., & Zhang, H. (2019). Discovery of Novel Anti-cryptosporidial Activities From Natural Products by in vitro High-Throughput Phenotypic Screening.. Front Microbiol. 10(AUG), 1999.
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  • Guo, F., Zhang, H., Eltahan, R., & Zhu, G. (2019). Molecular and Biochemical Characterization of a Type II Thioesterase From the Zoonotic Protozoan Parasite Cryptosporidium parvum.. Front Cell Infect Microbiol. 9(JUN), 199.
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Chapters3
  • Zhang, H., & Zhu, G. (2020). High-Throughput Screening of Drugs Against the Growth of Cryptosporidium parvum In Vitro by qRT-PCR.. Methods Mol Biol. Methods in Molecular Biology. 319-334. Springer New York.
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  • Zhu, G., & Guo, F. (2014). Cryptosporidium Metabolism. Cryptosporidium: parasite and disease. 361-379. Springer Vienna.
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  • Zhu, G. (2009). Energy metabolism and carbon flow in Cryptosporidium parvum. Giardia and Cryptosporidium: From Molecules to Diseases. 360-368.
Conference Papers4
  • Stejskal, F., Surinova, M., Hrdy, I., Fritzler, J. M., Zhu, G., & Korenkova, V. (2009). Inhibition of the Cryptosporidium parvum S-adenosylhomocysteine hydrolase with purine nucleoside analogues. TROPICAL MEDICINE & INTERNATIONAL HEALTH. 14, 220-220.
  • Chen, X., Ohara, S. P., Huang, B. Q., Nelson, J. B., Lin, J., Zhu, G., Ward, H. D., & LaRusso, N. F. (2004). Apical organelle discharge by Cryptosporidium parvum is temperature-, cytoskeleton- and intracellular calcium-dependent and required for host cell invasion. MOLECULAR BIOLOGY OF THE CELL. 15, 466A-467A.
  • Yarlett, N., Martinez, M. P., Zhu, G., Keithly, J. S., Woods, K., & Upton, S. J. (1996). Cryptosporidium parvum: polyamine biosynthesis from agmatine.. J Eukaryot Microbiol. 43(5), 73S-73S.
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Email
gzhu@tamu.edu
First Name
Guan
Last Name
Zhu
mailing address
Texas A&M University; Vet Med Pathobiology; 4467 TAMU
College Station, TX 77843-4467
USA