Wand, Joshua individual record
Professor and Department Head
overview

We are broadly interested in how the biophysical properties of proteins are manifested in their biological function. We are particularly engaged in trying to reveal the nature of internal protein motion and how this influences functions ranging from molecular recognition to allostery and catalysis. These basic ideas are being employed in a range of studies including protein engineering to optimize protein drugs, reverse micelle encapsulation to aid fragment-based drug discovery, understanding the regulation of Parkin, which is involved in mitophagy and early onset Parkinson's Disease, and the enzyme AKR1C3, which is central to resistant forms of prostate cancer.

education and training
selected publications
Academic Articles198
  • MacKenzie, D., Schaefer, A., Steckner, J., Leo, C. A., Naser, D., Artikis, E., ... Meiering, E. M. (2022). A fine balance of hydrophobic-electrostatic communication pathways in a pH-switching protein.. Proc Natl Acad Sci U S A. 119(26), e2119686119.
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  • Li, L., Chenna, B. C., Yang, K. S., Cole, T. R., Goodall, Z. T., Giardini, M., ... Meek, T. D. (2021). Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases.. J Med Chem. 64(15), 11267-11287.
  • Ando, N., Barquera, B., Bartlett, D. H., Boyd, E., Burnim, A. A., Byer, A. S., ... Watkins, M. B. (2021). The Molecular Basis for Life in Extreme Environments.. Annu Rev Biophys. 50(1), 343-372.
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  • Asangani, I., Blair, I. A., Van Duyne, G., Hilser, V. J., Moiseenkova-Bell, V., Plymate, S., ... Penning, T. M. (2021). Using Biochemistry & Biophysics to Extinguish Androgen Receptor Signaling in Prostate Cancer.. J Biol Chem. 296, 100240-100240.
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  • Marques, B. S., Stetz, M. A., Jorge, C., Valentine, K. G., Wand, A. J., & Nucci, N. V. (2020). Protein conformational entropy is not slaved to water.. Sci Rep. 10(1), 17587.
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Chapters19
  • Stetz, M. A., Caro, J. A., Kotaru, S., Yao, X., Marques, B. S., Valentine, K. G., & Wand, A. J. (2019). Characterization of Internal Protein Dynamics and Conformational Entropy by NMR Relaxation.. METHODS IN ENZYMOLOGY. Methods in Enzymology. 237-284. Elsevier.
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  • Jorge, C., Marques, B. S., Valentine, K. G., & Wand, A. J. (2019). Characterizing Protein Hydration Dynamics Using Solution NMR Spectroscopy.. METHODS IN ENZYMOLOGY. Methods in Enzymology. 77-101. Elsevier.
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  • Fuglestad, B., Marques, B. S., Jorge, C., Kerstetter, N. E., Valentine, K. G., & Wand, A. J. (2019). Reverse Micelle Encapsulation of Proteins for NMR Spectroscopy.. METHODS IN ENZYMOLOGY. Methods in Enzymology. 43-75. Elsevier.
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  • Wand, A. J. (2019). Preface.. METHODS IN ENZYMOLOGY. Methods in Enzymology. xv-xvii. Elsevier.
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  • Wand, A. J. (2019). Preface.. METHODS IN ENZYMOLOGY. Biological NMR Part A. xv-xvii. Elsevier.
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Conference Papers1
  • Fuglestad, B., Kerstetter, N. E., Bed'ard, S., & Wand, A. J. (2020). Using Reverse Micelles to Extend the Detection Limit of Weak Ligand-Protein Interactions. Biophysical Journal. 118(3), 324a-324a.
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Repository Documents / Preprints3
  • Bishop, A., Kotaru, S., Torres-Montalvo, G., Mimun, K., & Wand, A. (2022). Robust Automated Backbone Triple Resonance NMR Assignments of Proteins Using Bayesian-Based Simulated Annealing.
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  • Caro, J. A., Valentine, K. G., & Wand, A. J. (2021). Structural origins of protein conformational entropy.
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  • OBrien, E. S., Fuglestad, B., Lessen, H. J., Stetz, M. A., Lin, D. W., Marques, B. S., ... Wand, A. J. (2020). Membrane Proteins Have Distinct Fast Internal Motion and Residual Conformational Entropy.
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recent teaching activities
Email
wand@tamu.edu
First Name
Joshua
Last Name
Wand