Andrews-Polymenis, Helene individual record
Professor
overview

Salmonella is a leading cause of food borne illness, causing an estimated 1.4 million cases per year in the United States. Serovar Typhimurium is responsible for about 26% of these cases (CDC, 1998). The vast majority of Salmonella infections in mammals and birds are the result of infection with S. enterica subspecies I serovars, yet very few genetic factors that are necessary for intestinal persistence in these reservoirs have been described. Intestinal persistence is critical for shedding and transmission of serovar Typhimurium in mammals and birds, yet this phenomenon and interaction of the organism with the host immune system during persistent infection is poorly understood. The long-term goal of our work is to understand the genetic basis of persistence and host range restriction of Salmonella enterica serovar Typhimurium in its mammalian hosts.

selected publications
Academic Articles50
  • Bobonis, J., Mitosch, K., Mateus, A., Karcher, N., Kritikos, G., Selkrig, J., ... Typas, A. (2022). Bacterial retrons encode phage-defending tripartite toxin-antitoxin systems.. Nature. 609(7925), 144-150.
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  • Scoggin, K., Gupta, J., Lynch, R., Nagarajan, A., Aminian, M., Peterson, A., ... Andrews-Polymenis, H. L. (2022). Elucidating Mechanisms of Tolerance to Salmonella Typhimurium across Long-Term Infections Using the Collaborative Cross.. mBio. 13(4), e0112022-e01122.
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  • Scoggin, K., Lynch, R., Gupta, J., Nagarajan, A., Sheffield, M., Elsaadi, A., ... Andrews-Polymenis, H. L. (2022). Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross.. PLoS Genet. 18(4), e1010075-e1010075.
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  • Zhi, Y., Xiang, D. F., Narindoshvili, T., Andrews-Polymenis, H., & Raushel, F. M. (2020). Deciphering the Aldolase Function of STM3780 from a Bovine Enteric Infection-Related Gene Cluster in Salmonella enterica Serotype Typhimurium.. Biochemistry. 59(48), 4573-4580.
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  • Aminian, M., Andrews-Polymenis, H., Gupta, J., Kirby, M., Kvinge, H., Ma, X., ... Threadgill, D. (2020). Mathematical methods for visualization and anomaly detection in telemetry datasets.. Interface Focus. 10(1), 20190086-20190086.
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Chapters3
  • Canals, R., McClelland, M., Santiviago, C. A., & Andrews-Polymenis, H. (2011). Genomics of Salmonella Species. Wiedmann, M., & Zhang, W. (Eds.), Genomics of Foodborne Bacterial Pathogens. 171-235. Springer New York.
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  • Reynolds, M. M., Canals, R., McClelland, M., & Andrews-Polymenis, H. (2011). High-throughput Screening to Determine the Genetic Requirements for Salmonella Survival Under Different Growth Conditions. Porwolik, S. (Eds.), SALMONELLA: FROM GENOME TO FUNCTION. 69-89. Caister Academic Press.
  • Andrews-Polymenis, H., & Bumler, A. J. (2006). Pathogenomics of Salmonella Species. Pathogenomics. 109-124. Wiley-VCH Verlag GmbH & Co. KGaA.
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Conference Papers2
  • Pezoa, D., Andrews-Polymenis, H., Blondel, C. J., Leiva, L., Pinto, B., Alvarez, S. A., Santiviago, C. A., & Contreras, L. I. (2012). The type VI secretion systems encoded in Salmonella pathogenicity islands SPI-6 and SPI-19 contribute to intestinal colonization of chickens and systemic spread by Salmonella enterica serotype Typhimurium. FEBS JOURNAL. 279, 227-228.
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Repository Documents / Preprints6
  • Scoggin, K., Gupta, J., Lynch, R., Nagarajan, A., Aminian, M., Peterson, A., ... Andrews-Polymenis, H. L. (2022). Elucidating Mechanisms of Tolerance to Salmonella Typhimurium Across Long-Term Infections Using the Collaborative Cross.
    doi badge
  • Scoggin, K., Lynch, R., Gupta, J., Nagarajan, A., Sheffield, M., Elsaadi, A., ... Andrews-Polymenis, H. (2022). Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross.
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  • Nagarajan, A., Scoggin, K., Gupta, J., Threadgill, D. W., & Andrews-Polymenis, H. L. (2022). Using the Collaborative Cross to identify the role of host genetics in defining the murine gut microbiome.
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  • Bobonis, J., Mateus, A., Pfalz, B., Garcia-Santamarina, S., Galardini, M., Kobayashi, C., ... Typas, A. (2020). Bacterial retrons encode tripartite toxin/antitoxin systems.
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  • Bobonis, J., Mitosch, K., Mateus, A., Kritikos, G., Elfenbein, J. R., Savitski, M. M., Andrews-Polymenis, H., & Typas, A. (2020). Phage proteins block and trigger retron toxin/antitoxin systems.
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chaired theses and dissertations
Email
handrews@tamu.edu
First Name
Helene
Last Name
Andrews-Polymenis
mailing address
Texas A&M Health Science Center; Microbial Pathogenesis And Immunology; 8447 Riverside Parkway
Bryan, TX 77807
USA