Patrick, Kristin
individual record
Assistant Professor
Positions:
- Assistant Professor, Microbial Pathogenesis and Immunology, School of Medicine
UN Sustainable Development Goals:
UN Sustainable Development Goals:
overview
Using a multi-disciplinary toolset, we probe the molecular mechanisms that macrophages use to activate an innate immune response that is rapid, robust, and regulated. We mainly study how RNA binding proteins control the ability of macrophages to respond to infection, using a variety of bacterial and viral models. By working to uncover how RNA binding proteins work and how macrophages functionalize RNA binding proteins to orchestrate a fine-tuned innate immune response, our work furthers our understanding of a variety of human diseases.
education and training
- University of California, San Francisco - (San Francisco, California, United States), Postdoctoral Training
- Ph.D. in Microbiology, Yale University - (New Haven, Connecticut, United States) 2008
- B.A. in Biochemistry and Molecular Biology, Hamilton College - (Clinton, New York, United States) 2003
selected publications
Academic Articles30
- Weindel, C. G., Ellzey, L. M., Martinez, E. L., Watson, R. O., & Patrick, K. L. (2023). Gasdermins gone wild: new roles for GSDMs in regulating cellular homeostasis.. Trends Cell Biol. S0962-8924(23)00039-9.
- Wells, K. M., He, K., Pandey, A., Cabello, A., Zhang, D., Yang, J., ... de Figueiredo, P. (2022). Brucella activates the host RIDD pathway to subvert BLOS1-directed immune defense.. Elife. 11, e73625.
- Weindel, C. G., Zhao, X., Martinez, E., Bell, S. L., Vail, K. J., Coleman, A. K., ... Watson, R. O. (2022). Gasdermin D promotes hyperinflammation by triggering necroptosis in the presence of mitochondrial stress. The Journal of Immunology. 208(1_Supplement), 52.06-52.06.
- Wagner, A., Weindel, C., West, K., Watson, R., & Patrick, K. (2022). The splicing factor SRSF6 controls Mycobacterium tuberculosis replication through its role in maintaining mitochondrial homeostasis. The Journal of Immunology. 208(1_Supplement), 50.13-50.13.
- Weindel, C. G., Martinez, E. L., Zhao, X., Mabry, C. J., Bell, S. L., Vail, K. J., ... Watson, R. O. (2022). Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis.. Cell. 185(17), 3214-3231.e23.
Conference Papers3
- Weindel, C. G., Vail, K., Bell, S., Martinez, E., Patrick, K., & Watson, R. O. (2021). The Parkinson's disease-associated variant Lrrk2 G2019S confers hyper-susceptibility to inflammasome-mediated cell death and Mycobacterium tuberculosis pathogenesis. JOURNAL OF IMMUNOLOGY. 206(1_Supplement), 112.19-112.19.
- West, K., Patrick, K. L., & Watson, R. O. (2018). Heterogeneous ribonucleoprotein M influences specific cytokine outcomes upon Salmonella Typhimurium infection. JOURNAL OF IMMUNOLOGY. 200(1),
- Weindel, C. G., Bell, S. L., Vail, K., West, A. P., Patrick, K. L., & Watson, R. O. (2018). LRRK2 is required for macrophage homeostasis and the control of type I IFN. JOURNAL OF IMMUNOLOGY. 200(1),
Repository Documents / Preprints9
- Wagner, A. R., Weindel, C. G., West, K. O., Scott, H. M., Watson, R. O., & Patrick, K. L. (2022). SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX.
- Weindel, C. G., Zhao, X., Martinez, E., Bell, S. L., Vail, K. J., Coleman, A. K., ... Watson, R. O. (2021). Mitochondrial dysfunction promotes alternative gasdermin D-mediated inflammatory cell death and susceptibility to infection.
- Wells, K., He, K., Pandey, A., Cabello, A., Zhang, D., Yang, J., ... de Figueiredo, P. (2021). Diverse pathogens activate the host RIDD pathway to subvert BLOS1-directed immune defense.
- Sengupta, S., West, K. O., Sanghvi, S., Laliotis, G., Agosto, L. M., Lynch, K., ... Guerau-de-Arellano, M. (2021). PRMT5 promotes symmetric dimethylation of RNA processing proteins and modulates activated T cell alternative splicing and Ca2+/NFAT signaling.
- West, K. O., Wagner, A. R., Scott, H. M., Vail, K. J., Carter, K. E., Watson, R. O., & Patrick, K. L. (2020). Global transcriptomics reveals specialized roles for splicing regulatory proteins in the macrophage innate immune response.
researcher on
Principal Investigator1
Co-Principal Investigator1
recent teaching activities
- BICH491 Hnr-research Instructor
- BICH491 Research Instructor
- GENE491 Hnr-research Instructor
- GENE491 Research Instructor
- GENE491 Research: In-ab Instructor
Email
kpatrick03@tamu.edu
First Name
Kristin
Last Name
Patrick
mailing address
Texas A&M Health Science Center; Microbial Pathogenesis And Immunology; 1114 TAMUS
College Station, TX 77843-1114
USA
UN Sustainable Development Goals:
UN Sustainable Development Goals: