Scholars

Redox signaling is vital for proper immune system function, yet this area of research is understudied. My graduate career focused on the role of mitochondrial superoxide in T-lymphocyte development. I transitioned this expertise into my postdoctoral training where I examined the role of redox signaling in T-lymphocytes during the pathogenesis of cardiovascular disease. As an independent investigator, I have extended this work to identify the contribution of the immune system and redox signaling to different pathological states of psychological trauma and stress. With this, I am investigating the redox, metabolic, and epigenetic mechanisms that may affect immune cell function and potentiate psychological trauma-mediated inflammatory diseases.

education and training

University of Nebraska Medical Center - (Omaha, Nebraska, United States), Postdoctoral Training 2015
University of Iowa Hospitals and Clinics - (Iowa City, Iowa, United States), Postdoctoral Training 2012
Ph.D. in Free Radical and Radiation Biology, University of Iowa - (Iowa City, Iowa, United States) 2011
B.S. in Biochemistry, University of Iowa - (Iowa City, Iowa, United States) 2004

selected publications

Academic Articles84

Moore, T. A., & Case, A. J. (2022). Cytokine levels throughout the perinatal period.. J Matern Fetal Neonatal Med. 35(25), 5513-5519.
Reed, E., Lauten, T., Clopp, A., Moshfegh, C., Elkhatib, S., & Case, A. (2022). Mitochondrial Regulation of Inflammation after Psychological Trauma. Free Radical Biology and Medicine. 192, 33-34.
Costanzo-Garvey, D. L., Case, A. J., Watson, G. F., Alsamraae, M., Chatterjee, A., Oberley-Deegan, R. E., ... Cook, L. M. (2022). Prostate cancer addiction to oxidative stress defines sensitivity to anti-tumor neutrophils.. Clin Exp Metastasis. 39(4), 641-659.
Rana, S., Kour, S., Kizhake, S., King, H. M., Mallareddy, J. R., Case, A. J., Huxford, T., & Natarajan, A. (2022). Dimers of isatin derived -methylene--butyrolactone as potent anti-cancer agents.. Bioorg Med Chem Lett. 65, 128713-128713.
Elkhatib, S. K., Moshfegh, C. M., Watson, G. F., & Case, A. J. (2022). T-lymphocyte tyrosine hydroxylase regulates TH17 T-lymphocytes during repeated social defeat stress.. Brain Behav Immun. 104, 18-28.

Chapters1

Case, A. J., & Domann, F. E. (2009). HypoxiaInduced Gene Regulation through Hypoxia Inducible Factor1. Redox Signaling and Regulation in Biology and Medicine. 207-227. Wiley.

Conference Papers2

Moshfegh, C., Elkhatib, S., Watson, G., & Case, A. (2022). Calprotectin is Protective during Psychological Trauma. FREE RADICAL BIOLOGY AND MEDICINE. 180, 85-85.
Elkhatib, S., Moshfegh, C., Watson, G., & Case, A. (2022). T-Lymphocyte Tyrosine Hydroxylase Regulates IL-17A Downstream of Mitochondrial Superoxide. FREE RADICAL BIOLOGY AND MEDICINE. 180, 81-82.