Jon Skare is Professor and Associate Head of the Department of Microbial Pathogenesis and Immunology in the College of Medicine at Texas A&M University. He has been a faculty member at Texas A&M for over 20 years and has led a research laboratory centered around the pathogenic mechanisms operative in Borrelia burgdorferi, the spirochetal bacterium that causes Lyme disease. He has published over 50 peer reviewed manuscript, reviews, and book chapters and been funded continuously by the NIH since 1999 with over $14 million dollars in total costs. Dr. Skare has trained nine graduate students, fifteen postdoctoral fellows, and numerous undergraduate students in his research group during his time at Texas A&M. Several of his postdoctoral trainees and students have gone on to hold academic positions.
Research interests are focused on microbial pathogenesis with an emphasis in spirochetal infections, particularly Borrelia burgdorferi, the etiologic agent of Lyme disease. Broad training in the molecular biology, genetics, and biochemistry of prokaryotic systems is employed to answer research-related questions. Long-term interests in the lab are centered on understanding how B. burgdorferi promotes its pathogenic potential and persists in the disparate hosts it occupies in nature (e.g., both ticks and mammals). In this regard, the research program is aligned with: (i) regulatory pathways that contribute to the establishment of infection during the arthropod to mammalian transition; (ii) characterizing the response to oxidative stressors in B. burgdorferi and the regulation thereof; (iii) identifying and characterizing surface structures that contribute to the colonization and maintenance of infection via adherence mechanisms; and (iv) the ability of B. burgdorferi and relapsing fever Borrelia to persistently infect hosts in the face of a potent innate and adaptive immune response.
- University of California Los Angeles - (Los Angeles, California, United States), Postdoctoral Training 1996
- Ph.D. in Microbiology, Washington State University - (Pullman, Washington, United States) 1992
- B.S. in Biology, University of California, Irvine - (Irvine, California, United States) 1986
- Skare, J. T., & Garcia, B. L. (2020). Complement Evasion by Lyme Disease Spirochetes. TRENDS IN MICROBIOLOGY. 28(11), 889-899.
- Medina-Pérez, D. N., Wager, B., Troy, E., Gao, L., Norris, S. J., Lin, T., ... Skare, J. T. (2020). The intergenic small non-coding RNA ittA is required for optimal infectivity and tissue tropism in Borrelia burgdorferi. PLoS pathogens. 16(5), e1008423-e1008423.
- Phelan, J. P., Kern, A., Ramsey, M. E., Lundt, M. E., Sharma, B., Lin, T., ... Hu, L. T. (2019). Genome-wide screen identifies novel genes required for Borrelia burgdorferi survival in its Ixodes tick vector. PLoS pathogens. 15(5), e1007644-e1007644.
- Xie, J., Zhi, H., Garrigues, R. J., Keightley, A., Garcia, B. L., & Skare, J. T. (2019). Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes. PLoS pathogens. 15(3), e1007659-e1007659.
- Zhi, H., Xie, J., & Skare, J. T. (2018). The Classical Complement Pathway Is Required to Control Borrelia burgdorferi Levels During Experimental Infection. Frontiers in Immunology. 9(MAY), 959.
- Hyde, J. A., & Skare, J. T. (2018). Detection of Bioluminescent Borrelia burgdorferi from In Vitro Cultivation and During Murine Infection. Methods in molecular biology (Clifton, N.J.). Borrelia burgdorferi. (pp. 241-257). Springer New York.
- Virulence Mechanisms of Multifunctional Borrelial Proteins (Skare, Jon) awarded by NIAID 2020 - 2025