Karpac, Jason individual record
Associate Professor
Positions:
overview

The Karpac Lab is broadly interested in the origins of signaling networks that provide animals with metabolic flexibility, and thus the capacity to balance energy homeostasis. These ancient networks, under intense evolutionary pressure, both respond to and are shaped by diverse inputs, such as nutrient availability, pathogens, and aging. We primarily use the fruit fly Drosophila melanogaster as a genetic model to investigate the function and integration of these signaling networks at multiple levels of biological organization: from molecules, to cells and tissues, to inter-organ communication, to organismal physiology and aging.

selected publications
Academic Articles21
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  • Weindel, C. G., Martinez, E. L., Zhao, X., Mabry, C. J., Bell, S. L., Vail, K. J., ... Watson, R. O. (2022). Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis.. Cell. 185(17), 3214-3231.e23.
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  • Fuentes, N. R., Mlih, M., Wang, X., Webster, G., Cortes-Acosta, S., Salinas, M. L., ... Chapkin, R. S. (2021). Membrane therapy using DHA suppresses epidermal growth factor receptor signaling by disrupting nanocluster formation.. J Lipid Res. 62, 100026-100026.
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  • Zhao, X., & Karpac, J (2020). The Drosophila midgut and the systemic coordination of lipid-dependent energy homeostasis.. Curr Opin Insect Sci. 41, 100-105.
Email
karpac@tamu.edu
First Name
Jason
Last Name
Karpac
mailing address
Texas A&M University College of Medicine; Dept. of Molecular And Cellular Medicine; 8447 Riverside Parkway, MREB II
Bryan, TX 77807
USA