Karpac, Jason individual record
Associate Professor

The Karpac Lab is broadly interested in the origins of signaling networks that provide animals with metabolic flexibility, and thus the capacity to balance energy homeostasis. These ancient networks, under intense evolutionary pressure, both respond to and are shaped by diverse inputs, such as nutrient availability, pathogens, and aging. We primarily use the fruit fly Drosophila melanogaster as a genetic model to investigate the function and integration of these signaling networks at multiple levels of biological organization: from molecules, to cells and tissues, to inter-organ communication, to organismal physiology and aging.

selected publications
Academic Articles21
  • doi badge pubmed badge
  • Weindel, C. G., Martinez, E. L., Zhao, X., Mabry, C. J., Bell, S. L., Vail, K. J., ... Watson, R. O. (2022). Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis.. Cell. 185(17), 3214-3231.e23.
    doi badge pubmed badge
  • doi badge pubmed badge
  • Fuentes, N. R., Mlih, M., Wang, X., Webster, G., Cortes-Acosta, S., Salinas, M. L., ... Chapkin, R. S. (2021). Membrane therapy using DHA suppresses epidermal growth factor receptor signaling by disrupting nanocluster formation.. J Lipid Res. 62, 100026-100026.
    doi badge pubmed badge
  • Zhao, X., & Karpac, J (2020). The Drosophila midgut and the systemic coordination of lipid-dependent energy homeostasis.. Curr Opin Insect Sci. 41, 100-105.
First Name
Last Name
mailing address
Texas A&M University College of Medicine; Dept. of Molecular And Cellular Medicine; 8447 Riverside Parkway, MREB II
Bryan, TX 77807