The Karpac Lab is broadly interested in the origins of signaling networks that provide animals with metabolic flexibility, and thus the capacity to balance energy homeostasis. These ancient networks, under intense evolutionary pressure, both respond to and are shaped by diverse inputs, such as nutrient availability, pathogens, and aging. We primarily use the fruit fly Drosophila melanogaster as a genetic model to investigate the function and integration of these signaling networks at multiple levels of biological organization: from molecules, to cells and tissues, to inter-organ communication, to organismal physiology and aging.
- Buck Institute for Research on Aging - (Novato, California, United States), Postdoctoral Training 2014
- University of Rochester - (Rochester, New York, United States), Postdoctoral Training 2012
- Ph.D. in Cell Biology and Endocrinology, Oklahoma Medical Research Foundation - (Oklahoma City, Oklahoma, United States) 2007
- B.S. in Molecular Biology, Grove City College - (Grove City, Pennsylvania, United States) 2003
- Vandehoef, C., Molaei, M., & Karpac, J. (2020). Dietary Adaptation of Microbiota in Drosophila Requires NF-κB-Dependent Control of the Translational Regulator 4E-BP. CELL REPORTS. 31(10), 107736-107736.
- Zhao, X., Li, X., Shi, X., & Karpac, J. (2020). Diet‐MEF2 interactions shape lipid droplet diversification in muscle to influence Drosophila lifespan. Aging cell. e13172.
- Molaei, M., Vandehoef, C., & Karpac, J. (2019). NF-κB Shapes Metabolic Adaptation by Attenuating Foxo-Mediated Lipolysis in Drosophila. Developmental Cell. 49(5), 802-810.e6.
- Mlih, M., Khericha, M., Birdwell, C., West, A. P., & Karpac, J. (2018). A virus-acquired host cytokine controls systemic aging by antagonizing apoptosis. PLoS Biol. 16(7), e2005796-e2005796.
- Fuentes, N. R., Mlih, M., Barhoumi, R., Fan, Y., Hardin, P., Steele, T. J., ... Chapkin, R. S. (2018). Long chain n-3 fatty acids attenuate oncogenic KRas-driven proliferation by altering plasma membrane nanoscale proteolipid composition. CANCER RESEARCH. 78(14), canres.0324.2018-3912.