Pellois, Jean-Philippe individual record
Our goal is to determine how proteins function in space and time in the context of complex cellular networks. We focus on chemistry-driven approaches to manipulate protein structure beyond what is feasible with standard genetics. In particular, we use semi-synthetic light-activatable proteins as biophysical probes to investigate protein mechanisms inside living cells. Areas of interest include the important but poorly understood process of protein S-acylation, signal transduction, and protein trafficking.
education and training
- Ph.D. in , University of Houston - (Houston, Texas, United States) 2002
- M.Sc. in , ecole Superieure de Chimie Physique Electronique de Lyon - (Lyon, France) 1999
- Arora, M., Ganugula, R., Kumar, N., Kaur, G., Pellois, J., Garg, P., & Kumar, M. (2019). Next-Generation Noncompetitive Nanosystems Based on Gambogic Acid: In silico Identification of Transferrin Receptor Binding Sites, Regulatory Shelf Stability, and Their Preliminary Safety in Healthy Rodents.. ACS Appl Bio Mater. 2(8), 3540-3550.
- Pellois, J. (2019). Efficient and Innocuous Live-Cell Delivery: Making Membrane Barriers Disappear to Enable Cellular Biochemistry: How Better Cellular Delivery Tools Can Contribute to Precise and Quantitative Cell Biology Assays.. Bioessays. 41(6), e1900031-1900031.
- Brock, D. J., Kondow-McConaghy, H. M., Hager, E. C., & Pellois, J. (2019). Endosomal Escape and Cytosolic Penetration of Macromolecules Mediated by Synthetic Delivery Agents.. Bioconjug Chem. 30(2), 293-304.
- Fang, Y. u., Lian, X., Huang, Y., Fu, G., Xiao, Z., Wang, Q. i., ... Zhou, H. (2018). Investigating Subcellular Compartment Targeting Effect of Porous Coordination Cages for Enhancing Cancer Nanotherapy.. Small. 14(47), e1802709-1802709.
- Brock, D. J., Kustigian, L., Jiang, M., Graham, K., Wang, T., Erazo-Oliveras, A., ... Pellois, J. (2018). Efficient cell delivery mediated by lipid-specific endosomal escape of supercharged branched peptides.. Traffic. 19(6), 421-435.
- I-Corps: Cell Delivery Agent awarded by National Science Foundation 2017 - 2018
recent teaching activities
- BICH440 Biochemistry I Instructor
- BICH491 Hnr-research Instructor
- BICH491 Research Instructor
- BICH667 Molecular Probes Instructor
- BICH685 Directed Studies Instructor
chaired theses and dissertations
- Najjar, Kristina (2017-08). Identifying and Characterizing Molecular Parameters that Modulate the Endosomal Escape of Cationic Cell- Penetrating Peptides: A Structure Activity Approach. (Doctoral Dissertation)
- Wang, Ting-Yi (2016-08). Membrane Oxidation Governed Direct Plasma Membrane Translocation of Cell-Penetrating Peptides in Live Cells: Mechanisms and Implications. (Doctoral Dissertation)
- Erazo, Alfredo (2014-12). Cytosolic Delivery of Proteins, Peptides and Cell-Impermeable Small Molecules Into Live Cells Utilizing Virus-Inspired Multivalent Cell-Penetrating Peptides: Principles and Mechanisms. (Doctoral Dissertation)
- Muthukrishnan, Nandhini (2014-05). Intracellular Delivery Using Fluorophore-CPP Conjugates and Light: Mechanisms and Implications. (Doctoral Dissertation)
- Johnson, Gregory Andrew (2013-08). Targeted Killing of Bacteria by Conjugation of a Soluble Photosensitizer to an Antimicrobial Peptide: Priniciples and Mechanisms. (Doctoral Dissertation)
Texas A&M University; Biochemistry & Biophysics; 2128 TAMU
College Station, TX 77843-2128