Straight, Paul individual record
Associate Professor

Our goal is to understand how microorganisms interact in complex communities. Specifically, we study how small molecules produced in a microbial community affect the growth, development and metabolic output of the organisms. We use a combination of microbiology, genetic, genomic, and biochemical approaches to dissect complex interspecies interactions. Currently, our research focuses on the interactions of the soil bacteria Bacillus subtilis and members of the genus Streptomyces, known for their prolific production of bioactive small molecules and development of aerial structures and spores.

selected publications
Academic Articles28
  • Zhang, C., & Straight, P. D. (2019). Antibiotic discovery through microbial interactions. Current Opinion in Microbiology. 51, 64-71.
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  • Liu, Y., Kyle, S., & Straight, P. D. (2018). Antibiotic Stimulation of a Bacillus subtilis Migratory Response. mSphere. 3(1), e00586-e00517.
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  • Stubbendieck, R. M., Brock, D. J., Pellois, J., Gill, J. J., & Straight, P. D. (2018). Linearmycins are lytic membrane-targeting antibiotics. The Journal of Antibiotics. 71(3), 372-381.
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  • Hoefler, B. C., Stubbendieck, R. M., Josyula, N. K., Moisan, S. M., Schulze, E. M., & Straight, P. D. (2017). A Link between Linearmycin Biosynthesis and Extracellular Vesicle Genesis Connects Specialized Metabolism and Bacterial Membrane Physiology. Cell Chemical Biology. 24(10), 1238-1249.e7.
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  • Stubbendieck, R. M., & Straight, P. D. (2017). Linearmycins Activate a Two-Component Signaling System Involved in Bacterial Competition and Biofilm Morphology. JOURNAL OF BACTERIOLOGY. 199(18), e00186-e00117.
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  • Straight, P. D., & Kolter, R. (2009). Interspecies Chemical Communication in Bacterial Development. Annual Reviews.
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  • Hoefler, B. C., & Straight, P. D. (2014). Imaging Mass Spectrometry, Metabolism, and New Views of the Microbial World. Natural Products Analysis. 349-396. John Wiley & Sons, Inc.
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Conference Papers1
  • Bender, R. A., Downs, D., Kiley, P., LaRossa, R. A., Sonenshein, A. L., & Storz, G. (2008). Bridges and Chasms: Summary of the IMAGE 2 Meeting in Montreal, Canada, 30 April to 3 May 2007▿. JOURNAL OF BACTERIOLOGY. 190(3), 792-797.
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chaired theses and dissertations
First Name
Last Name
mailing address
Texas A&M University; Biochemistry & Biophysics; 2128 TAMU
College Station, TX 77843-2128