Our goal is to understand how microorganisms interact in complex communities. Specifically, we study how small molecules produced in a microbial community affect the growth, development and metabolic output of the organisms. We use a combination of microbiology, genetic, genomic, and biochemical approaches to dissect complex interspecies interactions. Currently, our research focuses on the interactions of the soil bacteria Bacillus subtilis and members of the genus Streptomyces, known for their prolific production of bioactive small molecules and development of aerial structures and spores.
- Zhang, C., & Straight, P. D. (2019). Antibiotic discovery through microbial interactions. 51, 64-71.
- Liu, Y., Kyle, S., & Straight, P. D. (2018). Antibiotic Stimulation of a Bacillus subtilis Migratory Response.. mSphere. (1), e00586-e00517.
- Stubbendieck, R. M., Brock, D. J., Pellois, J., Gill, J. J., & Straight, P. D. (2018). Linearmycins are lytic membrane-targeting antibiotics.. J Antibiot (Tokyo). (3), 372-381.
- Goodson, J. R., Klupt, S., Zhang, C., Straight, P., & Winkler, W. C. (2017). LoaP is a broadly conserved antiterminator protein that regulates antibiotic gene clusters in Bacillus amyloliquefaciens. 2(5), 17003.
- Hoefler, B. C., Stubbendieck, R. M., Josyula, N. K., Moisan, S. M., Schulze, E. M., & Straight, P. D. (2017). A Link between Linearmycin Biosynthesis and Extracellular Vesicle Genesis Connects Specialized Metabolism and Bacterial Membrane Physiology.. Cell Chem Biol. (10), 1238-1249.e7.
- Bender, R. A., Downs, D., Kiley, P., LaRossa, R. A., Sonenshein, A. L., & Storz, G. (2008). Bridges and Chasms: Summary of the IMAGE 2 Meeting in Montreal, Canada, 30 April to 3 May 2007▿. 190(3), 792-797.
- Stubbendieck, Reed Michael (2017-05). Discovering Linearmycins in Bacterial Competition: Lysis, Autolysis, and Resistance. (Doctoral Dissertation)
- Vargas Bautista, Carol M (2014-12). Complex Organization and Dynamic Regulation of the pks Gene Cluster in Bacillus subtilis. (Doctoral Dissertation)
- Gorzelnik, Karl V (2014-05). Competition-Mediated Identification of the First Environmental Protein Responsible for the Degradation of the Lipopeptide Surfactin. (Master's Thesis)