Meininger, Cynthia
individual record
Professor
Positions:
- Professor, Medical Physiology, College of Medicine
overview
My research focuses primarily on the vascular complications of diabetes. Using animal models of human diabetes, we have demonstrated that an inability of endothelial cells to produce nitric oxide may be partly responsible for these vascular complications. We are developing a gene/drug therapy approach for treating cardiovascular disease associated with diabetes. Targeted nanoparticles will deliver either the gene for GTPCH or BH4 itself into endothelial cells oxidatively damaged by diabetes to correct endothelial GTPCH deficiency, increase tetrahydrobiopterin levels, restore nitric oxide production and reverse the vascular dysfunction seen in diabetes. Our endothelium-targeting nanoparticle approach will not only reverse the damage caused by disease but will increase antioxidant levels to protect the endothelial cells from future damage and/or dysfunction.
education and training
- Texas A&M University - (College Station, Texas, United States), Postdoctoral Training 1989
- Ph.D. in Cell Biology, Texas A&M University - (College Station, Texas, United States) 1987
- B.A. in Cell Biology, University of South Florida - (Tampa, Florida, United States) 1980
selected publications
Academic Articles115
- Pal, S., Gasheva, O. Y., Zawieja, D. C., Meininger, C. J., & Gashev, A. A. (2020). Histamine-mediated autocrine signaling in mesenteric perilymphatic mast cells. AJP Regulatory Integrative and Comparative Physiology. 318(3), R590-R604.
- Wu, G., Brown, J., Zamora, M. L., Miller, A., Satterfield, M. C., Meininger, C. J., ... Zhang, R. (2019). Adverse organogenesis and predisposed long-term metabolic syndrome from prenatal exposure to fine particulate matter. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES. 116(24), 11590-11595.
- Tekwe, C. D., Yao, K., Lei, J., Li, X., Gupta, A., Luan, Y., ... Wu, G. (2019). Highlight article: Oral administration of alpha-ketoglutarate enhances nitric oxide synthesis by endothelial cells and whole-body insulin sensitivity in diet-induced obese rats. EXPERIMENTAL BIOLOGY AND MEDICINE. 244(13), 1081-1088.
- Gasheva, O. Y., Nizamutdinova, I. T., Hargrove, L., Gobbell, C., Troyanova-Wood, M., Alpini, S. F., ... Gashev, A. A. (2019). Prolonged intake of desloratadine: mesenteric lymphatic vessel dysfunction and development of obesity/metabolic syndrome. American journal of physiology. Gastrointestinal and liver physiology. 316(1), G217-G227.
- Lee, Y., Chakraborty, S., Meininger, C. J., & Muthuchamy, M. (2018). Insulin resistance disrupts cell integrity, mitochondrial function, and inflammatory signaling in lymphatic endothelium. Microcirculation (New York, N.Y. : 1994). 25(7), e12492-e12492.
Books1
- Wu, G., & Meininger, C. J. (2008). Analysis of citrulline, arginine, and methylarginines using high-performance liquid chromatography. Elsevier.
Chapters2
- Flynn, N. E., Meininger, C. J., Haynes, T. E., Shi, W., & Wu, G. (2005). Mechanisms for dietary regulation of nitric oxide synthesis in mammals. Nutrients and Cell Signaling. (pp. 225-252).
- Meininger, C. J., & Wu, G. Y. (2002). Regulation of endothelial cell proliferation by nitric oxide. MACROMOLECULAR CRYSTALLOGRAPHY, PT D. Methods in Enzymology. (pp. 280-295). Elsevier.
Conference Papers13
- Pal, S., Meininger, C. J., Gasheva, O., Griffith, W., Zawieja, D. C., & Gashev, A. A. (2018). Aging-associated alterations in lymphatic vessels and mast cells in perilymphatic tissues. JOURNAL OF IMMUNOLOGY. 200(1),
- Guoyao, W. u., Bazer, F. W., & Meininger, C. J. (2017). THE ROLE OF LEUCINE IN OBESITY-INDUCED METABOLIC DISORDERS. Annals of Nutrition and Metabolism. 71, 154-154.
- Francis, H. L., Onori, P., Mancinelli, R., Franchitto, A., Meng, F., Venter, J., ... Alpini, G. (2011). H1 histamine receptors accelerate the regrowth of the biliary tree after 70% hepatectomy. The FASEB Journal. 25,
- Dokken, B. B., Piermarini, C. V., Teachey, M. K., Gura, M., Dameff, C. J., Hilwig, R., Meininger, C. J., & Kern, K. (2010). Glucagon-like Peptide-1 Enhances Nitric Oxide Production by Coronary Endothelial Cells and improves Endothelium-dependent Coronary Microvascular Function after Cardiac Arrest and Resuscitation. FREE RADICAL BIOLOGY AND MEDICINE. 49, S20-S20.
- Alpini, G., Meng, F., Gaudio, E., Onori, P., Franchitto, A., Venter, J., ... Francis, H. (2009). H1 (BUT NOT H3) HISTAMINE RECEPTOR AGONISTS ACCELERATE THE REGROWTH OF THE BILIARY EPITHELIUM FOLLOWING 70% PARTIAL HEPATECTOMY BY INCREASED CHOLANGIOCYTE VEGF EXPRESSION. Hepatology (Baltimore, Md.). 50(4), 808A-808A.
teaching activities
- MEID707 Endo/repro Sci, Hum Sexuality Instructor
- MEID708 Integument/musculoskeletal Instructor
- MSCI685 Directed Studies Instructor
- MSCI691 Research Credit: Medical Sci Instructor
Email
cjm@tamu.edu
First Name
Cynthia
Last Name
Meininger
mailing address
Texas A&M Health Science Center; Medical Physiology; 1114 TAMUS
Temple, TX 76504
USA