Meininger, Cynthia individual record
Professor
overview

My research focuses primarily on the vascular complications of diabetes. Using animal models of human diabetes, we have demonstrated that an inability of endothelial cells to produce nitric oxide may be partly responsible for these vascular complications. We are developing a gene/drug therapy approach for treating cardiovascular disease associated with diabetes. Targeted nanoparticles will deliver either the gene for GTPCH or BH4 itself into endothelial cells oxidatively damaged by diabetes to correct endothelial GTPCH deficiency, increase tetrahydrobiopterin levels, restore nitric oxide production and reverse the vascular dysfunction seen in diabetes. Our endothelium-targeting nanoparticle approach will not only reverse the damage caused by disease but will increase antioxidant levels to protect the endothelial cells from future damage and/or dysfunction.

selected publications
Academic Articles118
  • Elmetwally, M. A., Li, X., Johnson, G. A., Burghardt, R. C., Herring, C. M., Kramer, A. C., ... Wu, G. (2022). Dietary supplementation with l-arginine between days 14 and 25 of gestation enhances NO and polyamine syntheses and the expression of angiogenic proteins in porcine placentae. Amino Acids. 54(2), 193-204.
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  • Wu, G., Meininger, C. J., McNeal, C. J., Bazer, F. W., & Rhoads, J. M. (2021). Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. Adv Exp Med Biol. 1332, 167-187.
  • Pal, S., Nath, S., Meininger, C. J., & Gashev, A. A. (2020). Emerging Roles of Mast Cells in the Regulation of Lymphatic Immuno-Physiology.. Front Immunol. 11, 1234.
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  • Si, H., Wang, J., Meininger, C. J., Peng, X. u., Zawieja, D. C., & Zhang, S. L. (2020). Ca2+ release-activated Ca2+ channels are responsible for histamine-induced Ca2+ entry, permeability increase, and interleukin synthesis in lymphatic endothelial cells.. Am J Physiol Heart Circ Physiol. 318(5), H1283-H1295.
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  • Pal, S., Gasheva, O. Y., Zawieja, D. C., Meininger, C. J., & Gashev, A. A. (2020). Histamine-mediated autocrine signaling in mesenteric perilymphatic mast cells.. Am J Physiol Regul Integr Comp Physiol. 318(3), R590-R604.
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Books1
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Chapters3
  • Sarkar, T. R., McNeal, C. J., Meininger, C. J., Niu, Y., Mallick, B. K., Carroll, R. J., & Wu, G. (2021). Dietary Intakes of Amino Acids and Other Nutrients by Adult Humans. MATHEMATICAL MODELLING IN EXPERIMENTAL NUTRITION. Wu, G.. (Eds.), Amino Acids in Nutrition and Health. Advances in Experimental Medicine and Biology. 211-227. Springer International Publishing.
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  • Shi, W., Wu, G., Meininger, C., Flynn, N., & Haynes, T. (2005). Mechanisms for Dietary Regulation of Nitric Oxide Synthesis in Mammals. Oxidative Stress and Disease. 225-252. CRC Press.
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  • Meininger, C. J., & Wu, G. (2002). Regulation of endothelial cell proliferation by nitric oxide.. MACROMOLECULAR CRYSTALLOGRAPHY, PT D. Methods in Enzymology. 280-295. Elsevier.
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Conference Papers14
  • Gashev, A. A., Gasheva, O. Y., Zawieja, D. C., Meininger, C. J., & Pal, S. (2020). Histamine‐mediated regulatory loop in mesenteric perilymphatic mast cells. The FASEB Journal. 34(S1), 1-1.
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  • Pal, S., Meininger, C. J., Gasheva, O., Griffith, W., Zawieja, D. C., & Gashev, A. A. (2018). Aging-associated alterations in lymphatic vessels and mast cells in perilymphatic tissues. JOURNAL OF IMMUNOLOGY. 200(1),
  • Guoyao, W. u., Bazer, F. W., & Meininger, C. J. (2017). THE ROLE OF LEUCINE IN OBESITY-INDUCED METABOLIC DISORDERS. ANNALS OF NUTRITION AND METABOLISM. 71, 154-154.
  • Francis, H. L., Onori, P., Mancinelli, R., Franchitto, A., Meng, F., Venter, J., ... Alpini, G. (2011). H1 histamine receptors accelerate the regrowth of the biliary tree after 70% hepatectomy. FASEB JOURNAL. 25,
  • Dokken, B. B., Piermarini, C. V., Teachey, M. K., Gura, M., Dameff, C. J., Hilwig, R., Meininger, C. J., & Kern, K. (2010). Glucagon-like Peptide-1 Enhances Nitric Oxide Production by Coronary Endothelial Cells and improves Endothelium-dependent Coronary Microvascular Function after Cardiac Arrest and Resuscitation. Free Radical Biology and Medicine. 49, S20-S20.
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Email
cjm@tamu.edu
First Name
Cynthia
Last Name
Meininger
mailing address
Texas A&M Health Science Center; Medical Physiology; 1114 TAMUS
Temple, TX 76504
USA