Scholars

I am currently building a research program that uses an integrative, translational approach to understand the mechanisms by which obesity promotes postmenopausal breast cancers. My work focuses on understanding how the obese microenvironment, when combined with the metabolic and hormonal changes associated with menopause, promote tumor development, survival, and growth. In parallel, I am investigating the role of adipose tissue inflammation in the development of metabolic disease after menopause. My hope is that the knowledge gained from studying the 'normal' adipose and breast environments during menopause will also help us understand the changes that occur to create a tumor-promoting environment in the breast of obese women during this same window of time.

education and training

University of Colorado Anschutz Medical Campus - (Aurora, Colorado, United States), Postdoctoral Training
Ph.D. in Medical Science, McMaster University - (Hamilton, Ontario, Canada) 2007
B.S. in Biomedical Science, University of Guelph - (Guelph, Ontario, Canada) 2000

selected publications

Academic Articles36

Sherk, V. D., Jackman, M. R., Higgins, J. A., Giles, E. D., Foright, R. M., Presby, D. M., ... Maclean, P. S. (2019). Impact of Exercise and Activity on Weight Regain and Musculoskeletal Health Post-Ovariectomy. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE. 51(12), 2465-2473.
Sherk, V. D., Carpenter, R. D., & Giles, E. D. (2019). Ibuprofen before Exercise Does Not Prevent Cortical Bone Adaptations to Training (vol 49, pg 888, 2017). MEDICINE AND SCIENCE IN SPORTS AND EXERCISE. 51(11), 2428-2428.
Presby, D. M., Checkley, L. A., Jackman, M. R., Higgins, J. A., Jones, K. L., Giles, E. D., ... MacLean, P. S. (2019). Regular exercise potentiates energetically expensive hepatic de novo lipogenesis during early weight regain. AJP Regulatory Integrative and Comparative Physiology. 317(5), R684-R695.
Giles, E. D., Brown, I. L., MacLean, P. S., Pan, Z., Melanson, E. L., Heard, K. J., ... Higgins, J. A. (2019). The In Vivo Net Energy Content of Resistant Starch and Its Effect on Macronutrient Oxidation in Healthy Adults. NUTRIENTS. 11(10), 2484-2484.
Giles, E. D., Jindal, S., Wellberg, E. A., Schedin, T., Anderson, S. M., Thor, A. D., ... Schedin, P. (2018). Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer. Breast Cancer Research. 20(1), 50.

Chapters1

Giles, E., & Singh, G. (2005). Role of TGF-β and IGF in Tumor Progression and Bone Metastases. Singh, G., & Rabbani, S. A. (Eds.), Bone Metastasis. (pp. 59-74). Humana Press.