Scholars

Assistant Professor

Positions:

Assistant Professor, Nutrition, College of Agriculture and Life Sciences

Research Areas:

Metabolism, Animal models in research, Exercise, Macrophages, Inflammation, Breast--Cancer, Obesity, Hormones, Adipose tissues, Menopause

UN Sustainable Development Goals:

Single Page Bio

Profile Summary

egiles@tamu.edu

Co-author Network

Map of Science

Co-investigator Network

Websites

Giles Lab

ORCID

0000-0002-8677-2831

UN Sustainable Development Goals:

Research Areas:

Metabolism, Animal models in research, Exercise, Macrophages, Inflammation, Breast--Cancer, Obesity, Hormones, Adipose tissues, Menopause

overview

I am currently building a research program that uses an integrative, translational approach to understand the mechanisms by which obesity promotes postmenopausal breast cancers. My work focuses on understanding how the obese microenvironment, when combined with the metabolic and hormonal changes associated with menopause, promote tumor development, survival, and growth. In parallel, I am investigating the role of adipose tissue inflammation in the development of metabolic disease after menopause. My hope is that the knowledge gained from studying the 'normal' adipose and breast environments during menopause will also help us understand the changes that occur to create a tumor-promoting environment in the breast of obese women during this same window of time.

education and training

University of Colorado Anschutz Medical Campus - (Aurora, Colorado, United States), Postdoctoral Training
Ph.D. in Medical Science, McMaster University - (Hamilton, Ontario, Canada) 2007
B.S. in Biomedical Science, University of Guelph - (Guelph, Ontario, Canada) 2000

selected publications

Academic Articles23

Glenny, E. M., Coleman, M. F., Giles, E. D., Wellberg, E. A., & Hursting, S. D. (2021). Designing Relevant Preclinical Rodent Models for Studying Links Between Nutrition, Obesity, Metabolism, and Cancer. Annual Review of Nutrition. 41(1), 253-282.
Wellberg, E. A., Corleto, K. A., Checkley, L. A., Jindal, S., Johnson, G., Higgins, J. A., ... Giles, E. D. (2021). Preventing ovariectomy-induced weight gain decreases tumor burden in rodent models of obesity and postmenopausal breast cancer. bioRxiv. 2021.10.18.464856.
Fabian, C. J., Klemp, J. R., Marchello, N. J., Vidoni, E. D., Sullivan, D. K., Nydegger, J. L., ... Kimler, B. F. (2021). Rapid Escalation of High-Volume Exercise during Caloric Restriction; Change in Visceral Adipose Tissue and Adipocytokines in Obese Sedentary Breast Cancer Survivors. Cancers. 13(19), 4871-4871.
Fabian, C. J., Befort, C. A., Phillips, T. A., Nydegger, J. L., Kreutzjans, A. L., Powers, K. R., ... Kimler, B. F. (2021). Change in Blood and Benign Breast Biomarkers in Women Undergoing a Weight Loss Intervention Randomized to High Dose ω-3 Fatty Acids vs Placebo.. Cancer Prev Res (Phila). 14(9), 893-904.
Giles, E. D., & Wellberg, E. A. (2020). Preclinical Models to Study Obesity and Breast Cancer in Females: Considerations, Caveats, and Tools.. J Mammary Gland Biol Neoplasia. 25(4), 237-253.

Chapters1

Giles, E., & Singh, G. (2005). Role of TGF- and IGF in Tumor Progression and Bone Metastases. Singh, G., & Rabbani, S. A. (Eds.), Bone Metastasis. 59-74. Humana Press.