Lele, Tanmay individual record
Professor
overview

Dr. Tanmay Lele's research is in the area of mechanobiology with a focus on cancer mechanobiology. His lab is interested in the molecular mechanisms by which cell generated mechanical forces and associated signaling pathways enable cell and tissue functions, and how these relationships become altered in cancer. Current research projects in the laboratory include quantitative measurements of nuclear forces, the effect of mechanical stresses on nuclear functions and gene expression, cellular adaptation to mechanical properties of the extracellular matrix, and the mechanics of cancer tissue development.



Lele is a scholar in cancer research at the Cancer Prevention and Research Institute of Texas.

education and training
selected publications
Academic Articles101
  • Dickinson, R. B., Katiyar, A., Dubell, C. R., & Lele, T. P. (2022). Viscous shaping of the compliant cell nucleus. APL Bioengineering. 6(1), 010901-010901.
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  • Tamashunas, A. C., Katiyar, A., Zhang, Q., Purkayastha, P., Singh, P. K., Chukkapalli, S. S., & Lele, T. P (2021). Osteoprotegerin is sensitive to actomyosin tension in human periodontal ligament fibroblasts.. J Cell Physiol. 236(8), 5715-5724.
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  • Purkayastha, P., Jaiswal, M. K., & Lele, T. P. (2021). Molecular cancer cell responses to solid compressive stress and interstitial fluid pressure. Cytoskeleton. 78(6), 312-322.
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  • Lele, T. (2021). Nuclear mechanics in migrating cells. The FASEB Journal. 35(S1),
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  • Purkayastha, P., Pendyala, K., Saxena, A. S., Hakimjavadi, H., Chamala, S., Dixit, P., Baer, C. F., & Lele, T. P. (2021). Reverse plasticity underlies rapid evolution by clonal selection within populations of fibroblasts propagated on a novel soft substrate.. Mol Biol Evol. 38(8), 3279-3293.
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Chapters7
  • Goldmann, W. H., Bechinger, B., & Lele, T. (2019). Chapter Eight Cytoskeletal Proteins at the Lipid Membrane. Advances in planar lipid bilayers and liposomes. Leitmannova Liu, A. (Eds.), Advances in Planar Lipid Bilayers and Liposomes. 227-264. Elsevier.
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  • Tocco, V. J., Neelam, S., Zhang, Q., Dickinson, R. B., & Lele, T. P. (2018). Direct Force Probe for Nuclear Mechanics.. Methods Mol Biol. The LINC Complex. 81-90. Springer New York.
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  • Lele, T., & Ingber, D. E. (2017). Focal Adhesions: Self-Assembling Nanoscale Mechanochemical Machines that Control Cell Function. Biomedical Nanostructures. 321-335. John Wiley & Sons, Inc..
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  • Alam, S., Lovett, D. B., Dickinson, R. B., Roux, K. J., & Lele, T. P. (2014). Nuclear forces and cell mechanosensing.. GENES AND OBESITY. Progress in Molecular Biology and Translational Science. 205-215. Elsevier.
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  • Lee, J., Clarke, N., & Lele, T. (2010). Enhanced Cell Growth, Function, and Differentiation by TiO2 Nanotube Surface Structuring. Nanotechnology in Tissue Engineering and Regenerative Medicine. 157-166. CRC Press.
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Conference Papers12
  • Tamashunas, A., Tocco, V., Matthews, J., Zhang, Q., Pathak, S., Licht, J., ... Lele, T. (2019). Gene screen reveals chromatin proteins influence abnormal nuclear morphology associated with breast cancer cell models. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 257,
  • Halfmann, C. T., Sears, R. M., Aman, L., Zhang, Q., Katiyar, A., O'Bryan, C. S., ... Roux, K. J. (2018). Barrier to autointegration factor (BAF) regulates the cellular response to nuclear rupture.. MOLECULAR BIOLOGY OF THE CELL. 29(26),
  • Tamashunas, A. C., Tocco, V. J., Matthews, J., Licht, J. D., Stephens, A. D., Luesch, H., & Lele, T. P. (2018). Gene screen reveals chromatin proteins influence abnormal nuclear morphology associated with breast cancer cell models.. MOLECULAR BIOLOGY OF THE CELL. 29(26),
  • Zhang, Q., Tamashunas, A. C., Torbati, M., Agrawal, A., Dickinson, R. B., Lammerding, J., & Lele, T. P. (2018). Local nuclear deformation in response to transient tensile stress can cause membrane rupture.. MOLECULAR BIOLOGY OF THE CELL. 29(26),
  • Wu, J., Chancellor, T., Shekhar, N., Mendonca, A., Dickinson, R. B., & Lele, T. P. (2016). Actomyosin tug-of-war advances the nucleus in a migrating tissue cell. MOLECULAR BIOLOGY OF THE CELL. 24,
Repository Documents / Preprints2
  • Antani, J. D., Sumali, A. X., Lele, T. P., & Lele, P. P (2020). Anisotropic random walks reveal chemotaxis signaling output in run-reversing bacteria.
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  • Purkayastha, P., Pendyala, K., Saxena, A. S., Hakimjavadi, H., Chamala, S., Dixit, P., Baer, C. F., & Lele, T. P. (2020). Reverse plasticity underlies rapid evolution by clonal selection within populations of fibroblasts propagated on a novel soft substrate.
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Email
tanmay.lele@tamu.edu
First Name
Tanmay
Last Name
Lele
mailing address
Department of Biomedical Engineering; Emerging Technologies Building, Room #5062, 101 Bizzell Street,; Texas A&M University
College Station, TX 77840., TX 77840
USA