Wilson, Van individual record
Associate Dean and Professor
overview

My area of specialization is the molecular biology of papovaviruses, with a primary focus on how viral proteins modify the host cell environment. Recently, we determined that the viral replication proteins, E1 and E2, are post-translationally modified by addition of 1 or more SUMO moieties. Sumoylation is a widespread modification whose biological functions are only recently becoming understood. Studies are in progress to 1) determine the role of sumoylation in the viral life cycle, 2) evaluate the effect of sumoylation on the structure and activity of the E1 helicase, 3) understand the mechanism by which sumoylation influences E2 stability and transcriptional activity, and 4) determine how sumoylation is modulated by the viral E6 oncoprotein. In addition to the role of sumoylation in the viral life cycle, we are also exploring how sumoylation participates in normal keratinocyte differentiation. We have developed a keratinocyte cell line inducibly expressing a tagged SUMO moiety to facilitate proteomics studies of sumoylation changes and regulation during controlled differentiation.

selected publications
Academic Articles77
Books1
  • Wilson, V. G. (2009). SUMO regulation of cellular processes. Springer Netherlands.
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Chapters9
  • Wilson, V. G. (2017). Introduction to Sumoylation. MATHEMATICAL MODELLING IN EXPERIMENTAL NUTRITION. SUMO Regulation of Cellular Processes. (pp. 1-12). Springer International Publishing.
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  • Wilson, V. G. (2013). Growth and Differentiation of HaCaT Keratinocytes. Methods in Molecular Biology. Epidermal Cells. (pp. 33-41).
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  • Wilson, V. G., & Heaton, P. (2011). Deltapapillomavirus. Tidona, C., & Darai, G. (Eds.), The Springer Index of Viruses. (pp. 1051-1056). Springer New York.
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  • Wilson, V. G., & Heaton, P. (2011). Etapapillomavirus. Tidona, C., & Darai, G. (Eds.), The Springer Index of Viruses. (pp. 1065-1068). Springer New York.
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  • Wilson, V. G. (2009). Introduction to sumoylation. SUMO Regulation of Cellular Processes. (pp. 1-10). Springer Netherlands.
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Conference Papers4
editor of
Books1
Email
v-wilson@tamu.edu
First Name
Van
Last Name
Wilson
mailing address
Texas A&M Health Science Center; Instructional Admin; 1359 TAMUS
Bryan, TX 77807-1359
USA