overview

Dr. Kapler's broad research interests are concerned with the replication and transmission of eukaryotic chromosomes. The failure to completely replicate the genome during S phase or partially re-replicate chromosomes leads to genome instability- a hallmark of cancer cells. The central questions investigated in the laboratory are concerned with how replication initiation sites are established in chromosomes and how they are regulated during conventional (G1/S/G2/M) and alternative cell cycles, including endoreplication (gap-S-gap-S...) and locus-specific gene amplification. The current focus of the lab is to use high throughput (nascent strand) DNA sequencing to generate a comprehensive map of replication initiation sites under different physiological conditions.

selected publications
Academic Articles29
Chapters1
Conference Papers1
chaired theses and dissertations
Email
gkapler@tamhsc.edu
First Name
Geoffrey
Last Name
Kapler
mailing address
Texas A&M Health Science Center; Instructional Admin; 1114 TAMUS
College Station, TX 77843-1114
USA