Research in the Chapkin lab focuses on dietary/microbial modulators related to the prevention of cancer and chronic inflammatory diseases.
Our central goal is to (1) understand cancer chemoprevention at a fundamental level, and (2) to test pharmaceutical agents in combination with dietary/microbial (countermeasures to the Western diet) to more effectively improve gut health and reduce systemic chronic inflammation. Since diet influences gut microbiota composition and metabolite production, to unravel the interrelationships among gut health and the structure of the gut microbial ecosystem, we are in the process of evaluating (using transgenic mouse, Drosophila models and humans) how the gut microbiome modulates intestinal cells, innate immune cells and tumors. As part of this endeavor, we are modeling at the molecular level the dynamic relationship between diet and gut microbe-derived metabolites which modulate chronic inflammation and the hierarchical cellular organization of the intestine, e.g., stem cell niche.
- Ph.D. in Nutrition and Physiological Chemistry, University of California, Davis - (Davis, California, United States) 1986
- M.Sc. in Nutrition, University of Guelph - (Guelph, Ontario, Canada) 1983
- B.Sc. in Nutrition and Biochemistry, University of Guelph - (Guelph, Ontario, Canada) 1981
- Chapkin, R. S., Navarro, S. L., Hullar, M., & Lampe, J. W. (2020). Diet and Gut Microbes Act Coordinately to Enhance Programmed Cell Death and Reduce Colorectal Cancer Risk.. Digestive Diseases and Sciences.
- Salinas, M. L., Fuentes, N. R., Choate, R., Wright, R. C., McMurray, D. N., & Chapkin, R. S. (2019). AdipoRon Attenuates Wnt Signaling by Reducing Cholesterol-Dependent Plasma Membrane Rigidity.. Biophys J.
- Kim, E., Wright, G. A., Zoh, R. S., Patil, B. S., Jayaprakasha, G. K., Callaway, E. S., ... Chapkin, R. S. (2019). Establishment of a multicomponent dietary bioactive human equivalent dose to delete damaged Lgr5+ stem cells using a mouse colon tumor initiation model.. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 28(5), 383-389.
- Fan, Y., Davidson, L. A., & Chapkin, R. S. (2019). Murine Colonic Organoid Culture System and Downstream Assay Applications.. Methods in molecular biology (Clifton, N.J.). 1576, 171-181.
- Fuentes, N. R., Mlih, M., Barhoumi, R., Fan, Y., Hardin, P., Steele, T. J., ... Chapkin, R. S. (2018). Long chain n-3 fatty acids attenuate oncogenic KRas-driven proliferation by altering plasma membrane nanoscale proteolipid composition. CANCER RESEARCH. 78(14), canres.0324.2018-3912.
- Hou, T. Y., McMurray, D. N., & Chapkin, R. S. (2017). Omega-3 fatty acids and T-cell responses. Nutrition, Immunity, and Infection. (pp. 295-314). CRC Press.
- Turk, H. F., Monk, J. M., Hou, T. Y., & Chapkin, R. S. (2013). Omega-3 fatty acids in cancer prevention and control: A membrane perspective. Obesity, Inflammation and Cancer. (pp. 306-339).
- Monk, J. M., McMurray, D. N., & Chapkin, R. S. (2011). Clinical Effects of n-3 PUFA Supplementation in Human Health and Inflammatory Diseases. Omega-3 Oils: Applications in Functional Foods. (pp. 31-60).
- Chapkin, R. S. (2007). Reappraisal of the essential fatty acids. Fatty Acids in Foods and their Health Implications, Third Edition. (pp. 675-691).
- Stillwell, W., Shaikh, S. R., LoCascio, D., Siddiqui, R. A., Seo, J., Chapkin, R. S., & Wassall, S. R. (2006). Docosahexaenoic acid. An influential membrane-altering omega-3 fatty acid. Frontiers in Nutrition Research. (pp. 249-271).
- Fuentes, N. R., Barhoumi, R., Mlih, M., Karpac, J., Hardin, P., Steele, T., ... Chapkin, R. S. (2017). Abstract 179: Plasma membrane lipid therapy: disruption of oncogenic Ras spatiotemporal organization by membrane-targeted dietary bioactives (MTDB). CANCER RESEARCH. 77, 179-179.
- Salinas, M. L., Fuentes, N. R., Barhoumi, R., & Chapkin, R. S. (2017). Abstract 255: Dietary amphiphilic polyphenols modulate the biophysical properties of plasma membrane organization and membrane-dependent macropinocytosis. CANCER RESEARCH. 77, 255-255.
- Kim, E., Davidson, L. A., Patil, B. S., Jayaprakasha, G. K., Callaway, E. S., Turner, N. D., & Chapkin, R. S. (2014). Effects of chemoprotective diets on crypt adult stem cells u the cells of origin of colon cancer. The FASEB Journal. 28(1),
- Wang, M., Li, M., Chapkin, R. S., Ivanov, I., & Donovan, S. M. (2013). Fecal microbiome and metabolites differ between breast and formula-fed human infants. The FASEB Journal. 27,
- Turk, H. F., & Chapkin, R. S. (2012). DHA alters EGFR spatiotemporal dynamics to suppress signal transduction. The FASEB Journal. 26,
- Kim, Eun Joo (2017-12). Spatiotemporal Effects of Dietary Bioactives on Lgr5+ Stem Cells during Colon Tumorigenesis. (Doctoral Dissertation)
- Fuentes, Natividad R (2017-12). Plasma Membrane Lipid Therapy: Disruption of Oncogenic Ras Driven Phenotypes by Membrane Targeted Dietary Bioactives (Mtdb). (Doctoral Dissertation)
- Triff, Karen (2016-05). Assessment of Histone Tail Modifications and Transcriptional Profiling during Colon Cancer Progression: Effect of Chemoprotective Natural Compounds. (Doctoral Dissertation)
- Hou, Tim Yu-Tien (2014-12). n-3 Polyunsaturated Fatty Acids Alter Mouse CD4+ T Cell Activation by Modifying the Lipid Bilayer Properties. (Doctoral Dissertation)
- Allen, Marilyn Jean (2014-08). N-3 Polyunsaturated Fatty Acids Reduce Th17 Differentiation by Decreasing Responsiveness to Interleukin-6 in Mice. (Master's Thesis)