Li, Jianrong individual record
Professor, Neurobiology, Veterinary Integrative Biosciences
overview

The central goal of our research is to understand how oligodendroglial development in the mammalian central nervous system is regulated in health and disease. Specifically, we are interested in molecular and cellular mechanisms involved in oligodendrocyte death as occurring in white matter injuries, such as multiple sclerosis and cerebral palsy. Because in most CNS diseases, multiple cell types including neurons, glial cells and vascular cells are involved via complex interactions, we investigate, at the cellular and molecular level, the role of microglia and astrocytes in the process of oligodendrocyte development, differentiation and cell death. We use a variety of methods including primary

cell cultures and transgenic and knockout animals to elucidate signal transduction pathways in mediating oligodendrocyte injury.

The second focus of our laboratory is to elucidate the signals that promote oligodendrocyte survival and regeneration/remyelination after injury, and to study cell-cell interactions that regulate remyelination. These studies should contribute significantly to our understanding of mechanisms of oligodendrocyte development and injury, and provide new clues for potential prevention and treatment of human white matter diseases.

selected publications
Academic Articles49
  • Lu, H. C., Kim, S., Steelman, A. J., Tracy, K., Zhou, B., Michaud, D., ... Li, J. (2020). STAT3 signaling in myeloid cells promotes pathogenic myelin-specific T cell differentiation and autoimmune demyelination.. Proc Natl Acad Sci U S A. 117(10), 5430-5441.
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  • Stoughton, W. B., Li, J., Balog-Alvarez, C., & Kornegay, J. N. (2018). Impaired autophagy correlates with golden retriever muscular dystrophy phenotype.. Muscle Nerve. 58(3), 418-426.
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  • Kim, S., Bielawski, J., Yang, H., Kong, Y. u., Zhou, B., & Li, J. (2018). Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination.. Glia. 66(3), 654-669.
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  • Steelman, A. J., Zhou, Y., Koito, H., Kim, S., Payne, H. R., Lu, Q. R., & Li, J. (2016). Activation of oligodendroglial Stat3 is required for efficient remyelination.. Neurobiol Dis. 91, 336-346.
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  • Zhao, C., Deng, Y., Liu, L., Yu, K., Zhang, L., Wang, H., ... Lu, Q. R. (2016). Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation.. Nat Commun. 7(1), 10883.
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Chapters2
  • Park, J., Kim, S., Li, J., & Han, A. (2014). Axon length quantification microfluidic culture platform for growth and regeneration study.. Methods Mol Biol. Murray, A. J. (Eds.), Methods in Molecular Biology. 85-95. Springer New York.
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  • Li, J., & Billiar, T. R. (2002). Nitric Oxide. Encyclopedia of Molecular Biology. John Wiley & Sons, Inc..
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Conference Papers14
  • Jeong, S. H., Kim, S., Buonocore, J., Park, J., Welsh, C. J., Li, J., & Han, A. (2016). A multi-channel in vitro blood-brain barrier model. 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. 493-494.
  • Park, J., Kim, S., Li, J., & Han, A. (2014). Brain-on-a-chip: An in vitro myelination model. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. 150-152.
  • Park, J., Kim, S., Li, J., & Han, A. (2011). Quantitative CNS AXON growth analysis for drug screening in a microfluidic neuron culture platform. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. 1, 699-701.
  • Park, J., Koito, H., Li, J., & Han, A. (2010). High-throughput compartmentalized cns neuron culture platform for axon degeneration/regeneration study. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 2, 860-862.
  • Park, J., Koito, H., Li, J., & Han, A. (2010). Neuron aggregate culture platform for in vitro cns myelination study. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 1, 46-48.
recent teaching activities
chaired theses and dissertations
Email
jianrong.li@tamu.edu
First Name
Jianrong
Last Name
Li
mailing address
Texas A&M University; Veterinary Integrative Biosciences; 4458 TAMU
College Station, TX 77843-4458
USA