Li, Jianrong individual record
Professor, Neurobiology, Veterinary Integrative Biosciences

The central goal of our research is to understand how oligodendroglial development in the mammalian central nervous system is regulated in health and disease. Specifically, we are interested in molecular and cellular mechanisms involved in oligodendrocyte death as occurring in white matter injuries, such as multiple sclerosis and cerebral palsy. Because in most CNS diseases, multiple cell types including neurons, glial cells and vascular cells are involved via complex interactions, we investigate, at the cellular and molecular level, the role of microglia and astrocytes in the process of oligodendrocyte development, differentiation and cell death. We use a variety of methods including primary

cell cultures and transgenic and knockout animals to elucidate signal transduction pathways in mediating oligodendrocyte injury.

The second focus of our laboratory is to elucidate the signals that promote oligodendrocyte survival and regeneration/remyelination after injury, and to study cell-cell interactions that regulate remyelination. These studies should contribute significantly to our understanding of mechanisms of oligodendrocyte development and injury, and provide new clues for potential prevention and treatment of human white matter diseases.

selected publications
Academic Articles45
  • Park, J., Kim, S., Li, J., & Han, A. (2014). Axon length quantification microfluidic culture platform for growth and regeneration study.. Methods in molecular biology (Clifton, N.J.). Murray, A. J. (Eds.), Axon Growth and Regeneration. (pp. 85-95). Springer New York.
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  • Li, J., & Billiar, T. R. (2002). Nitric Oxide. Encyclopedia of Molecular Biology. John Wiley & Sons, Inc..
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Conference Papers14
chaired theses and dissertations
First Name
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mailing address
Texas A&M University; Veterinary Integrative Biosciences; 4458 TAMU
College Station, TX 77843-4458